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Psychiatrie, Neurologie, Und... Aug 1951
Topics: Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 14875787
DOI: No ID Found -
Nederlands Tijdschrift Voor Geneeskunde Dec 1954
Topics: Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13235930
DOI: No ID Found -
Der Nervenarzt Aug 2023Dysphagia is a clinically relevant problem in Parkinson's disease as well as in atypical Parkinsonian syndromes, such as multiple system atrophy and diseases from the... (Review)
Review
Dysphagia is a clinically relevant problem in Parkinson's disease as well as in atypical Parkinsonian syndromes, such as multiple system atrophy and diseases from the spectrum of 4‑repeat tauopathies, which affect most patients to a varying degree in the course of their disease. This results in relevant restrictions in daily life due to impaired intake of food, fluids, and medication with a subsequent reduction in quality of life. This article not only gives an overview of the pathophysiological causes of dysphagia in the various Parkinson syndromes, but also presents screening, diagnostic and treatment procedures that have been investigated for the different diseases.
Topics: Humans; Deglutition Disorders; Quality of Life; Parkinsonian Disorders; Parkinson Disease; Multiple System Atrophy
PubMed: 37115255
DOI: 10.1007/s00115-023-01475-7 -
Neurodegenerative Disease Management Dec 2021Mutations in which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of...
Mutations in which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of PD relies upon clinically defined motor features which appear after irreversible neurodegeneration. Prodromal symptoms of PD may provide a means to predict latent pathology, years before the onset of motor features. Previous work has reported prodromal features of PD in mutation carriers, however this has been insufficiently sensitive to identify those that will develop PD. The Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease (RAPSODI GD) study assesses a large cohort of mutation carriers, to aid development of procedures for earlier diagnosis of PD.
Topics: Gaucher Disease; Glucosylceramidase; Humans; Mutation; Parkinson Disease; Parkinsonian Disorders; Prodromal Symptoms
PubMed: 34666501
DOI: 10.2217/nmt-2021-0032 -
Movement Disorders : Official Journal... Feb 2020Objective assessments of movement impairment are needed to support clinical trials and facilitate diagnosis. The objective of the current study was to determine if a...
BACKGROUND
Objective assessments of movement impairment are needed to support clinical trials and facilitate diagnosis. The objective of the current study was to determine if a rapid web-based computer mouse test (Hevelius) could detect and accurately measure ataxia and parkinsonism.
METHODS
Ninety-five ataxia, 46 parkinsonism, and 29 control participants and 229,017 online participants completed Hevelius. We trained machine-learning models on age-normalized Hevelius features to (1) measure severity and disease progression and (2) distinguish phenotypes from controls and from each other.
RESULTS
Regression model estimates correlated strongly with clinical scores (from r = 0.66 for UPDRS dominant arm total to r = 0.83 for the Brief Ataxia Rating Scale). A disease change model identified ataxia progression with high sensitivity. Classification models distinguished ataxia or parkinsonism from healthy controls with high sensitivity (≥0.91) and specificity (≥0.90).
CONCLUSIONS
Hevelius produces a granular and accurate motor assessment in a few minutes of mouse use and may be useful as an outcome measure and screening tool. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ataxia; Child; Child, Preschool; Computers; Disease Progression; Female; Humans; Male; Middle Aged; Parkinson Disease; Parkinsonian Disorders; Young Adult
PubMed: 31769069
DOI: 10.1002/mds.27915 -
Connecticut Medicine Jun 1959
Topics: Parkinson Disease; Parkinsonian Disorders
PubMed: 13652546
DOI: No ID Found -
Modern Hospital Dec 1954
Topics: Drug Therapy; Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13213946
DOI: No ID Found -
The American Journal of Nursing Oct 1959
Topics: Basal Ganglia; Ganglia; Parkinson Disease; Parkinsonian Disorders
PubMed: 14428801
DOI: No ID Found -
Therapie Der Gegenwart Nov 1956
Topics: Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13391819
DOI: No ID Found -
Movement Disorders Clinical Practice Mar 2024
Topics: Male; Child; Humans; Developmental Disabilities; Parkinsonian Disorders; Parkinson Disease; Mutation
PubMed: 38293822
DOI: 10.1002/mdc3.13953