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The Practitioner Jul 1953
Topics: Disease Management; Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13064098
DOI: No ID Found -
Journal of Parkinson's Disease 2014We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and...
We performed a clinical report based, descriptive and retrospective study, aimed at comparing Flunarizine/Cinnarizine-induced parkinsonism (FCIP) patients and Parkinson's disease (PD) patients. The FCIP group (n = 30) presented a lower frequency of rigidity and unilateral tremor than the PD group (n = 70). All FCIP patients improved, 13 after dopaminergic treatment. FCIP patients who improved spontaneously presented lower frequency of rigidity, compared with the other FCIP subgroup and PD group. FCIP patients who did not improve spontaneously showed a clinical pattern similar to PD patients.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Cinnarizine; Dopamine Agonists; Female; Flunarizine; Humans; Male; Middle Aged; Muscle Rigidity; Parkinson Disease; Parkinsonian Disorders; Retrospective Studies; Statistics, Nonparametric; Treatment Outcome; Tremor
PubMed: 25125483
DOI: 10.3233/JPD-140414 -
Bulletin of the New York Academy of... Oct 1956
Topics: Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13364582
DOI: No ID Found -
British Medical Journal Nov 1958
Topics: Parkinson Disease; Parkinsonian Disorders
PubMed: 13584906
DOI: 10.1136/bmj.2.5106.1214 -
The American Surgeon Nov 1956
Topics: Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 13381899
DOI: No ID Found -
Lancet (London, England) May 1955
Topics: Parkinson Disease; Parkinsonian Disorders
PubMed: 14382509
DOI: No ID Found -
Practical Neurology Apr 2012Separating Parkinson's disease from the various causes of atypical parkinsonism (AP) is a common and clinically relevant challenge in clinical practice. Distinguishing... (Review)
Review
Separating Parkinson's disease from the various causes of atypical parkinsonism (AP) is a common and clinically relevant challenge in clinical practice. Distinguishing between the different causes of AP is even more difficult. Here the authors discuss a systematic, clinically based and three-pronged approach that can assist clinicians in establishing the correct diagnosis in the consulting room. The three consecutive steps include: (1) to verify that the clinical syndrome truly represents parkinsonism (hypokinetic-rigid syndrome); (2) to search systematically for 'red flags' (alarm signs that may signal the presence of AP); and (3) to integrate these two steps, as a basis for a narrow differential diagnosis and a guide for further ancillary tests.
Topics: Aged; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases; Parkinson Disease; Parkinsonian Disorders; Sleep Wake Disorders
PubMed: 22450452
DOI: 10.1136/practneurol-2011-000132 -
La Revue Du Praticien Oct 2021ATYPICAL PARKINSONIAN SYNDROMES Idiopathic Parkinson's disease is the most common cause of parkinsonism, but in almost 40 % of cases, parkinsonism is due to other...
ATYPICAL PARKINSONIAN SYNDROMES Idiopathic Parkinson's disease is the most common cause of parkinsonism, but in almost 40 % of cases, parkinsonism is due to other causes. The diagnosis of atypical parkinsonian syndromes remains difficult at the early stage. Parkinson's syndrome is associated with other symptoms called «red flags». These red flags need to be identified during the clinical examination. Unlike Parkinson's disease, dopaminergic treatment are slightly effective on motor symptoms. The prognosis is worst, with a faster progression. The life expectation is reduced compared to Parkinson's disease. Diagnosis certainty, given by anatomopathology, is not available during the patient's lifetime. Advances in functional imaging improve diagnosis accuracy. Clinical course answers diagnosis uncertainties in a few month or years. The follow up is multidisciplinary. No treatment is currently available.
Topics: Diagnosis, Differential; Humans; Parkinson Disease; Parkinsonian Disorders; Prognosis
PubMed: 35147346
DOI: No ID Found -
Current Neurology and Neuroscience... Jul 2004The basal ganglia and its associated circuitry can be assessed with a variety of neuroimaging methods that can provide information regarding specific neurotransmitter... (Review)
Review
The basal ganglia and its associated circuitry can be assessed with a variety of neuroimaging methods that can provide information regarding specific neurotransmitter systems, the functional activity of brain regions, and the structural integrity of these regions. In Parkinson's disease (PD) and related atypical parkinsonian syndromes (APS), these imaging methods may be useful for many reasons, including aiding in differential diagnosis and measuring the efficacy of new therapies. This paper reviews recent developments in the application of neuroimaging to the assessment of PD and related APS.
Topics: Animals; Basal Ganglia; Diagnostic Imaging; Humans; Parkinson Disease; Parkinsonian Disorders
PubMed: 15217542
DOI: 10.1007/s11910-004-0053-1 -
Parkinsonism & Related Disorders Nov 2023We report a 37-year-old Caucasian male with history of developmental delay, childhood onset Intellectual Disability (ID) and attention deficit hyperactivity disorder...
We report a 37-year-old Caucasian male with history of developmental delay, childhood onset Intellectual Disability (ID) and attention deficit hyperactivity disorder (ADHD) who presented at the age of 34 with tremor-dominant parkinsonism. Next Generation Sequencing (NGS) revealed pathogenic hemizygous sequence variant, c.200G > T, in the RAB39B gene. This report expands the number of described individuals with young onset PD associated with RAB39B mutation.
Topics: Adult; Child; Humans; Male; Intellectual Disability; Levodopa; Mutation; Parkinson Disease; Parkinsonian Disorders
PubMed: 37844350
DOI: 10.1016/j.parkreldis.2023.105855