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Indian Journal of Thoracic and... Jan 2022Parosteal osteosarcoma represents a low-grade, well-differentiated type of cortical surface osteosarcoma with a relatively better prognosis. Systemic metastasis is rare...
Parosteal osteosarcoma represents a low-grade, well-differentiated type of cortical surface osteosarcoma with a relatively better prognosis. Systemic metastasis is rare overall and occurs in 10-15% of patients only. Delayed recurrences (>5 years) of parosteal osteosarcoma are even rarer and only few isolated case reports of local recurrence with systemic metastasis occurring beyond 10 years exist in the literature. We present here a case of femoral parosteal osteosarcoma, successfully treated previously, that recurred with high-grade transformation locally and with lung metastasis after 12 years. The patient was managed by lung wedge resection followed by type A1 rotationplasty. Histopathology report confirmed evidence of high-grade transformation (de-differentiation) both locally and at the metastatic site, in view of strong CDK4 and MDM2 nuclear immuno-expression. The present report highlights the importance of long-term follow-up, even for a seemingly less aggressive osteosarcoma variant with identification of a novel pattern of lung metastasis.
PubMed: 34898877
DOI: 10.1007/s12055-021-01214-0 -
AJR. American Journal of Roentgenology May 1999
Topics: Bone Neoplasms; Humans; Osteochondroma; Osteosarcoma, Juxtacortical
PubMed: 10227535
DOI: 10.2214/ajr.172.5.10227535 -
Der Orthopade Mar 2020This case study deals with the case of a 16-year-old male patient with a low-grade parosteal osteosarcoma of the distal femur with focal differentiation. Case history,...
This case study deals with the case of a 16-year-old male patient with a low-grade parosteal osteosarcoma of the distal femur with focal differentiation. Case history, disease course, and surgery as well as the pathological workup with final diagnosis are presented. Relevant radiologic and pathologic differential diagnoses und diagnostic pitfalls are explained in detail and discussed. Additionally, postoperative treatment options are illustrated.
Topics: Adolescent; Bone Neoplasms; Diagnosis, Differential; Femur; Humans; Male; Osteosarcoma; Osteosarcoma, Juxtacortical
PubMed: 31919554
DOI: 10.1007/s00132-019-03849-9 -
Skeletal Radiology Mar 1998Parosteal osteosarcoma is an uncommon, low-grade malignant bone tumor and is found in an older age group than conventional osteosarcoma. We present a talar parosteal... (Review)
Review
Parosteal osteosarcoma is an uncommon, low-grade malignant bone tumor and is found in an older age group than conventional osteosarcoma. We present a talar parosteal osteosarcoma that recurred twice in a 2-year-old child. To our knowledge, this is the youngest patient reported with a parosteal osteosarcoma. The talus is an unusual site for parosteal osteosarcoma. Inadequate resection due to a diagnosis of juxtacortical chondroma resulted in recurrence of the tumor. The age of the patient, the thick cartilaginous cap, and well-differentiated trabecular bone all contributed to the critical erroneous diagnosis.
Topics: Bone Neoplasms; Child, Preschool; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Osteosarcoma, Juxtacortical; Talus
PubMed: 9554007
DOI: 10.1007/s002560050356 -
The American Journal of Roentgenology,... Jan 1969
Topics: Adult; Amputation, Surgical; Biopsy; Bone Neoplasms; Female; Femoral Neoplasms; Humans; Male; Middle Aged; Osteosarcoma; Radiography; Wrist
PubMed: 5251358
DOI: 10.2214/ajr.105.1.142 -
The American Surgeon Nov 1964
Topics: Amputation, Surgical; Fingers; Lung Neoplasms; Neoplasm Metastasis; Neoplasms; Osteosarcoma; Pathology; Pelvic Neoplasms; Periosteum; Radiography; Sarcoma; Surgical Procedures, Operative; Tibia
PubMed: 14217111
DOI: No ID Found -
Radiology Case Reports Feb 2019Parosteal osteosarcoma originates on the surface of long bones. The juxtacortical variety is one of the most common ones and accounts for about 5% of all osteosarcomas....
Parosteal osteosarcoma originates on the surface of long bones. The juxtacortical variety is one of the most common ones and accounts for about 5% of all osteosarcomas. We report the case of a 34-year-old female patient with a rare variant of parosteal osteosarcoma. Because of the less aggressive biological behavior, it is important to know it, in order to recognize and differentiate it from benign osseous lesions.
PubMed: 30425774
DOI: 10.1016/j.radcr.2018.10.028 -
Indian Journal of Pathology &... 2008Parosteal osteosarcoma is a well-differentiated, predominantly fibro-osseous variant of osteosarcoma, accounting for 5% of all osteosarcomas. We report a case of...
Parosteal osteosarcoma is a well-differentiated, predominantly fibro-osseous variant of osteosarcoma, accounting for 5% of all osteosarcomas. We report a case of parosteal osteosarcoma in the metaphyseal area of right femur, of 2 years' duration in a male aged 35 years. It was mistaken for osteochondroma in the initial biopsy, and the possibility of bizarre parosteal osteochondromatous proliferation (BPOP) was also considered. Subsequent excision of the tumor showed it to be a parosteal osteosarcoma. The patient had recurrence of the lesion after 1 year, and he attended a cancer institute. Follow-up showed metastases of the tumor on bone scan.
Topics: Adult; Bone Neoplasms; Diagnosis, Differential; Femur; Humans; Male; Neoplasm Metastasis; Osteochondroma; Osteosarcoma; Radiography; Recurrence
PubMed: 18417858
DOI: 10.4103/0377-4929.40399 -
Dento Maxillo Facial Radiology Sep 1997We describe the case of a 47-year-old female who presented with a small nodule in the buccal sulcus in the left maxillary incisor region. Clinical and radiographic... (Review)
Review
We describe the case of a 47-year-old female who presented with a small nodule in the buccal sulcus in the left maxillary incisor region. Clinical and radiographic examination revealed a small sclerotic neoplasm with a short pedicle. Histopathological examination confirmed a diagnosis of parosteal osteosarcoma. The contribution of CT to the diagnosis and management is discussed.
Topics: Female; Humans; Maxilla; Maxillary Neoplasms; Middle Aged; Osteosarcoma, Juxtacortical; Periosteum; Tomography, X-Ray Computed
PubMed: 9482005
DOI: 10.1038/sj.dmfr.4600262 -
Skeletal Radiology Jan 2021Parosteal osteosarcomas and well-differentiated liposarcomas are both well-differentiated locally aggressive tumors. They both have simple karyotypes with amplification...
Parosteal osteosarcomas and well-differentiated liposarcomas are both well-differentiated locally aggressive tumors. They both have simple karyotypes with amplification of the 12q13-15 regions including MDM2 and CDK4 genes. In this report, we describe the case of a parosteal osteosarcoma intertwined with a low-grade component similar to a well-differentiated liposarcoma. The association of a bone component with an adipose component was initially overlooked. We describe the histological, imaging, and molecular characteristics of this tumor stressing the importance of radio-pathological correlation. To our knowledge, this is the second report of a parosteal osteoliposarcoma. Awareness of this rare presentation may allow radiologists and surgeons to recognize the peripheral fatty component as an integral part of the tumor.
Topics: Bone Neoplasms; Cyclin-Dependent Kinase 4; Humans; Liposarcoma; Osteosarcoma; Proto-Oncogene Proteins c-mdm2
PubMed: 32564106
DOI: 10.1007/s00256-020-03509-6