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Current Opinion in Otolaryngology &... Apr 2015This article presents a summary of the recent publications on the diagnosis and management of primary malignant parotid epithelial neoplasm, with special emphasis on... (Review)
Review
PURPOSE OF REVIEW
This article presents a summary of the recent publications on the diagnosis and management of primary malignant parotid epithelial neoplasm, with special emphasis on evaluation and treatment of nodal metastases.
RECENT FINDINGS
Pathologists are challenged with making a diagnosis, classification and grading of salivary gland cancers. The unpredictable behaviour of this disease has been documented by clinicians reporting aggressiveness and variations in disease patterns within a single-cancer subgroup. Surgeons have identified a high incidence of occult nodal disease both at the primary site and the neck, which has frequently been understaged both clinically and on imaging in the presurgical workup.
SUMMARY
The significance of a high incidence of occult nodal disease both at the primary site and the neck is that a more aggressive therapeutic strategy must be directed/advised by the multidisciplinary clinical team, to the disease located in the head and neck, thus improving likely cure, preventing local and distant disease failure.
Topics: Adult; Carcinoma; Child; Humans; Lymphatic Metastasis; Neoplasm Staging; Parotid Neoplasms
PubMed: 25692631
DOI: 10.1097/MOO.0000000000000139 -
Ethiopian Journal of Health Sciences Jan 2023Intraductal carcinoma is a rare low grade neoplasm of salivary glands with an excellent prognosis. It most frequently occurs in the parotid gland. Ectopic localizations... (Review)
Review
BACKGROUND
Intraductal carcinoma is a rare low grade neoplasm of salivary glands with an excellent prognosis. It most frequently occurs in the parotid gland. Ectopic localizations are quite rare.
METHODS
This case report describes a man in his 60's who was referred to ear, nose and throat outpatient department with 1-month history of painless swelling of the right parotid region.
RESULTS
Ultrasound-guided fine-needle aspiration unveiled a cytologic specimen judged as "suspicious for malignancy" and patient underwent a partial superficial parotidectomy. Immunohistochemistry confirmed diagnosis of intraductal carcinoma of right parotid gland.
CONCLUSIONS
There are few reported cases concerning this clinical entity following thorough review of the literature and recent developments with reference to the contribution of cytology and histopathology will probably modify its classification and management.
Topics: Male; Humans; Carcinoma, Intraductal, Noninfiltrating; Parotid Gland; Parotid Neoplasms; Biopsy, Fine-Needle; Immunohistochemistry
PubMed: 36890933
DOI: 10.4314/ejhs.v33i1.21 -
Surgical Infections Jun 2023
Topics: Humans; Parotid Neoplasms; Tuberculosis; Parotid Diseases
PubMed: 36720003
DOI: 10.1089/sur.2022.332 -
Nihon Jibiinkoka Gakkai Kaiho Aug 2013
Review
Topics: Facial Paralysis; Humans; Neoplasm Staging; Parotid Neoplasms; Postoperative Complications; Prognosis
PubMed: 24312974
DOI: 10.3950/jibiinkoka.116.941 -
Otolaryngologic Clinics of North America Apr 2016This article reviews the epidemiology, embryology, risk factors, clinical presentation, diagnostic work-up, and basic management principles for the more common benign... (Review)
Review
This article reviews the epidemiology, embryology, risk factors, clinical presentation, diagnostic work-up, and basic management principles for the more common benign parotid neoplasms. The various histopathologies are also discussed and summarized.
Topics: Adenoma, Pleomorphic; Biopsy, Fine-Needle; Humans; Neoplasm Recurrence, Local; Parotid Gland; Parotid Neoplasms
PubMed: 27040584
DOI: 10.1016/j.otc.2015.10.005 -
Advances in Oto-rhino-laryngology 2016In many regions of the world, the most common type of parotid malignancy is metastatic malignancy. Metastatic cutaneous squamous cell carcinoma and metastatic melanoma... (Review)
Review
In many regions of the world, the most common type of parotid malignancy is metastatic malignancy. Metastatic cutaneous squamous cell carcinoma and metastatic melanoma are the most common pathologies that metastasize to the parotid gland and cervical lymph nodes. Other more rare metastatic malignancies from cutaneous primary sites include Merkel cell carcinoma, pleomorphic sarcoma (previously called malignant fibrous histiocytoma) and metastatic basal cell carcinoma. Systemic metastases can also occur from tumors such as renal cell carcinoma. This review will focus on the management of the two most common causes of parotid malignancy.
Topics: Disease Management; Humans; Neoplasm Metastasis; Parotid Gland; Parotid Neoplasms
PubMed: 27092549
DOI: 10.1159/000442129 -
Head & Face Medicine Mar 2021The purpose of this study is to determine the histopathological spectrum and risk of primary malignancy of asymptomatic parotid lesions incidentally discovered on...
BACKGROUND
The purpose of this study is to determine the histopathological spectrum and risk of primary malignancy of asymptomatic parotid lesions incidentally discovered on cross-sectional imaging.
METHODS
Over a 10-year period, 154 patients underwent 163 ultrasound-guided parotid lesion biopsies at our institution. This retrospective chart review included 89 lesions in 87 patients with asymptomatic parotid lesions discovered on cross-sectional imaging studies performed for unrelated clinical indications. The histopathologic findings of all sampled lesions were reviewed. We evaluated the patient demographics and pathological diagnoses of sampled parotid lesions to determine the histopathological spectrum and risk of malignancy.
RESULTS
The average age was 67.5 years and 92 % were males. 25 % of patients had bilateral lesions. The average size of the parotid lesions was 1.5 cm and 91 % were located in the superficial lobe. 92.1 % of lesions were benign with Warthin tumor being the most common diagnosis followed by pleomorphic adenoma. 2.3 % of lesions were primary parotid malignant neoplasms, while 5.6 % were metastatic lesions in patients with known malignancy.
CONCLUSIONS
The incidence of primary parotid malignant neoplasm in asymptomatic incidentally discovered parotid lesions is low. Imaging or clinical follow-up may be considered in patients with incidental parotid lesions who prefer to avoid biopsy.
Topics: Adenolymphoma; Aged; Biopsy; Female; Humans; Male; Parotid Gland; Parotid Neoplasms; Retrospective Studies
PubMed: 33757536
DOI: 10.1186/s13005-021-00262-6 -
The Journal of Craniofacial Surgery Sep 2013To study the effectiveness and safety of acellular dermal matrix (ADM) graft in preventing Frey syndrome after parotid neoplasm surgery, we reviewed foreign reported... (Review)
Review
OBJECTIVE
To study the effectiveness and safety of acellular dermal matrix (ADM) graft in preventing Frey syndrome after parotid neoplasm surgery, we reviewed foreign reported clinical randomized controlled trials systematically. Based on this review, we aimed to assess the effectiveness of ADM graft and provide reliable evidence for clinical application.
METHODS
We reviewed foreign-language databases, such as MEDLINE, applied meta-analysis with Rev.Man 5, and drew forest plots with odds ratio as effect size.
RESULTS
Three trials were recruited. The morbidity of Frey syndrome in experimental group was significantly lower than that in control on both subjective index and objective index, with odds ratios at 0.03 (95% confidence interval, 0.01-0.11) and 0.03 (95% confidence interval, 0.01-0.12), respectively. There was no significant difference between ADM group and blank control in total adverse reactions and complication incidence, whereas results differed for a kind of specific adverse reaction or complication.
CONCLUSIONS
Based on existing research data, implanting ADM could effectively prevent Frey syndrome, and its poor prognosis effects did not significantly increase, which suggested that its total safety was reliable. Nevertheless, further investigations about the difference on a specific adverse reaction or complication were still needed.
Topics: Acellular Dermis; Humans; Parotid Neoplasms; Postoperative Complications; Skin Transplantation; Sweating, Gustatory; Treatment Outcome
PubMed: 24036719
DOI: 10.1097/SCS.0b013e31828dcdb3 -
Acta Otorhinolaryngologica Italica :... Jun 2005Malignant tumours of the parotid gland represent a group of relatively rare lesions. The medical records of 363 patients with parotid swelling treated between 1974 and...
Malignant tumours of the parotid gland represent a group of relatively rare lesions. The medical records of 363 patients with parotid swelling treated between 1974 and 2003 at the "G. Ferreri" Department of Otorhinolaryngology, "La Sapienza" University in Rome were retrospectively analysed. Clinical presentation, pre-operative investigations, surgical procedure, histopathology report, post-operative complications, and the oncological results of 19 patients who underwent extended radical parotidectomy for malignant neoplasm of the parotid gland are discussed. Extended radical parotidectomy, reserved for neoplasms in an advanced stage, involves the removal of the entire parotid gland, with sacrifice of the facial nerve and the resection en bloc of the adjacent structures affected by neoplastic infiltration, such as the temporal bone, the mandibular bone, the skin, blood vessels and nerves. In addition to this surgical treatment, a cycle of adjuvant radiotherapy is also necessary. The overall rate of survival at 10 years depends mainly on the histological characteristics of the tumour, and, in this series, is reported to be approximately 58%. These data indicate that total extended radical parotidectomy combined with post-operative radiotherapy, represents the best therapeutic approach with regard both to quality of life and life expectancy, in patients with an advanced stage of malignant neoplasm of the parotid gland.
Topics: Adult; Combined Modality Therapy; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Otorhinolaryngologic Surgical Procedures; Parotid Neoplasms; Tomography, X-Ray Computed
PubMed: 16450772
DOI: No ID Found -
Oral Surgery, Oral Medicine, Oral... Jul 2006We report the case of an 8-year-old boy with a parotid mass diagnosed to be a leiomyosarcoma. Considering the unresectable extent of the mass, the patient was subjected... (Review)
Review
We report the case of an 8-year-old boy with a parotid mass diagnosed to be a leiomyosarcoma. Considering the unresectable extent of the mass, the patient was subjected to radiotherapy. The patient developed distant metastasis following the course of radiotherapy and was put on chemotherapy. The child was lost to further follow up. To our knowledge, this is the first reported case in the English-language literature of such an entity in the pediatric age group.
Topics: Child; Humans; Leiomyosarcoma; Male; Parotid Neoplasms
PubMed: 16831677
DOI: 10.1016/j.tripleo.2005.07.034