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Graefe's Archive For Clinical and... Aug 2017
Topics: Adolescent; Cataract; Cataract Extraction; Child; Child, Preschool; Humans; Lens Implantation, Intraocular; Pars Planitis
PubMed: 28593425
DOI: 10.1007/s00417-017-3698-6 -
American Journal of Ophthalmology Jun 1987
Topics: Exudates and Transudates; Humans; Terminology as Topic; Uveitis
PubMed: 3591882
DOI: 10.1016/s0002-9394(14)74403-4 -
Transactions of the Ophthalmological... 1986The records on thirty-three patients (58 eyes) with the diagnosis of pars planitis were reviewed. The patients were divided into 4 groups: Group 1 had bilateral vitreous...
The records on thirty-three patients (58 eyes) with the diagnosis of pars planitis were reviewed. The patients were divided into 4 groups: Group 1 had bilateral vitreous cells and pars plana 'snowbank' formation (13 patients, 26 eyes), Group 2 had bilateral vitreous cells and 'snowbank' formation in one eye only (8 patients, 16 eyes), Group 3 had vitreous cells and 'snowbank' formation in one eye only (8 patients, 8 eyes), and Group 4 had bilateral vitreous cells without 'snowbank' formation (4 patients, 8 eyes). Frequent findings and complications were tabulated; cystoid macular oedema was the most common cause of decreased vision. Although pars plana 'snowbank' exudates are usually present in pars planitis, they may not be necessary to make the diagnosis. An approach to therapy is outlined.
Topics: Adolescent; Adult; Child; Ciliary Body; Cyclosporins; Female; Humans; Macular Edema; Male; Methylprednisolone; Middle Aged; Uveitis; Vision Disorders; Visual Acuity
PubMed: 3467497
DOI: No ID Found -
Transactions of the Ophthalmological... Sep 1981We have studied seven eyes from six patients with longstanding pars planitis. Two eyes were phthisical. The remaining five eyes from four patients showed similar...
We have studied seven eyes from six patients with longstanding pars planitis. Two eyes were phthisical. The remaining five eyes from four patients showed similar findings and included retinal phlebitis, disc and macular oedema, and the presence of a 'snowbank' over the inferior peripheral retina and pars plana. The snowbank consisted of posteriorly detached and collapsed vitreous in which cellular proliferation from the retina with non-pigmented ciliary epithelium was present. Electron microscopy showed the presence of fibrous astrocytes and collagen in two eyes. Retinal neovascularization extended into the snowbank in one case. We have also studied vitreous and preretinal membranes and a portion of a snowbank obtained by pars plana vitrectomy from two eyes of two young patients with active pars planitis. The snowbank and preretinal membranes contained fibrous astrocytes and new collagen and the vitreous snowballs consisted of granulomatous inflammation.
Topics: Adolescent; Adult; Child; Ciliary Body; Eye Diseases; Female; Granuloma; Humans; Microscopy, Electron; Middle Aged; Uveitis; Vitreous Body
PubMed: 6963826
DOI: No ID Found -
American Journal of Ophthalmology Aug 2021To determine classification criteria for intermediate uveitis, non-pars planitis type (IU-NPP, also known as undifferentiated intermediate uveitis).
PURPOSE
To determine classification criteria for intermediate uveitis, non-pars planitis type (IU-NPP, also known as undifferentiated intermediate uveitis).
DESIGN
Machine learning of cases with IU-NPP and 4 other intermediate uveitides.
METHODS
Cases of intermediate uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the intermediate uveitides. The resulting criteria were evaluated on the validation set.
RESULTS
Five hundred eighty-nine of cases of intermediate uveitides, including 114 cases of IU-NPP, were evaluated by machine learning. The overall accuracy for intermediate uveitides was 99.8% in the training set and 99.3% in the validation set (95% confidence interval 96.1, 99.9). Key criteria for IU-NPP included unilateral or bilateral intermediate uveitis with neither snowballs in the vitreous humor nor snowbanks on the pars plana. Other key exclusions included multiple sclerosis, sarcoidosis, and syphilis. The misclassification rates for IU-NPP were 0% in the training set and 0% in the validation set.
CONCLUSIONS
The criteria for IU-NPP had a low misclassification rate and seemed to perform well enough for use in clinical and translational research.
Topics: Adult; Female; Humans; Machine Learning; Male; Middle Aged; Pars Planitis; Uveitis, Intermediate; Visual Acuity; Young Adult
PubMed: 33839089
DOI: 10.1016/j.ajo.2021.03.054 -
American Journal of Ophthalmology Apr 1987
Topics: Autoimmune Diseases; Ciliary Body; Cornea; Endothelium; Humans; Keratitis; Terminology as Topic; Uveitis; Uveitis, Anterior
PubMed: 3565524
DOI: 10.1016/s0002-9394(14)74294-1 -
Ocular Immunology and Inflammation Jun 2001During retrospective and prospective studies, we attempted to determine the clinical characteristics, treatment, and visual outcome of patients with pars planitis and to...
During retrospective and prospective studies, we attempted to determine the clinical characteristics, treatment, and visual outcome of patients with pars planitis and to evaluate the association between pars planitis and multiple sclerosis (MS). The retrospective study included 44 patients with pars planitis, who had been examined between October 1986 and January 1999. We analyzed age, sex, visual acuity (VA), median follow-up time, and medical and surgical treatments. The prospective study, which included 21 consecutive patients with pars planitis, was performed to determine the presence of MS. In the retrospective study, the mean patient age was 22.4 years (SD +/- 11.5) and the median follow-up was 34.9 months (SD +/- 27.2). Complications included macular edema (47.7%), vitreous opacities (38.6%), papillitis (38.6%), vasculitis (36.4%), and cataract (20.5%). Forty patients (90.9%) had a final bilateral VA better than 20/40. In the prospective study, magnetic resonance imaging (MRI) was performed. Demyelinating lesions were found in 10 (47.6%) of the 21 patients and relapsing-remitting clinically definite MS was diagnosed in seven (33.3%). With the exception of age, no significantly statistical differences were observed when the visual prognosis and the clinical and epidemiologic characteristics were compared between the two groups of patients with and without associated MS; a diagnosis of MS was more frequently made in patients over 25 years of age. With appropriate treatment, patients with pars planitis have a good visual prognosis. Because the presence of demyelinating lesions seems to be high among patients with pars planitis, MRI should be considered, especially in patients over 25 years of age.
Topics: Adolescent; Adult; Age Distribution; Anti-Inflammatory Agents, Non-Steroidal; Cryotherapy; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Multiple Sclerosis; Pars Planitis; Prognosis; Prospective Studies; Retrospective Studies; Sex Distribution; Spain; Visual Acuity; Vitrectomy
PubMed: 11449325
DOI: 10.1076/ocii.9.2.93.3975 -
Transactions of the Ophthalmological... 1977
Topics: Adolescent; Adult; Child; Ciliary Body; Humans; Middle Aged; Retina; Uveitis, Anterior
PubMed: 269542
DOI: No ID Found -
Graefe's Archive For Clinical and... Aug 2020Pars planitis is a commonly observed type of pediatric uveitis. The aim of this study was to evaluate the implications of pars planitis-associated cystoid macular edema...
PURPOSE
Pars planitis is a commonly observed type of pediatric uveitis. The aim of this study was to evaluate the implications of pars planitis-associated cystoid macular edema (CME) on visual outcome and treatment modalities.
METHODS
A retrospective review of medical records in a single center with academic practice.
RESULTS
Included were 33 children (mean age 8 years, 58 eyes). Eighteen eyes developed CME (31%): in 67% of them, CME was diagnosed at presentation and in 33%, it developed at a mean of 57 months after presentation. Anterior and posterior segment complications were more prevalent in eyes with CME. Papillitis was significantly associated with the development of CME (OR 12.4, 95% CI 2.3 to 65.6, p = 0.003). Patients with CME were 1.7 times more likely to be treated with systemic therapy. By the last follow-up, 50% of patients who never developed CME were without systemic therapy compared with 13% of patients who developed CME (p = 0.034). LogMAR visual acuity improvement between presentation and month 36 was 0.41 for eyes with CME compared with 0.14 for eyes that never developed CME (p = 0.009).
CONCLUSION
Pars planitis-associated CME entailed higher prevalence of ocular complications, more frequent use of immunomodulatory therapy, and a lower rate of remission.
Topics: Adolescent; Child; Child, Preschool; Disease Management; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunosuppressive Agents; Macular Edema; Male; Pars Planitis; Prognosis; Retrospective Studies; Visual Acuity
PubMed: 32346784
DOI: 10.1007/s00417-020-04696-7