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American Journal of Ophthalmology Nov 1986A migrating endothelial rejection line is the clinical criterion of specific immune reaction in corneal allotransplantation. This line when seen in otherwise intact...
A migrating endothelial rejection line is the clinical criterion of specific immune reaction in corneal allotransplantation. This line when seen in otherwise intact corneas has been presumed to be an autoimmune endotheliopathy. We have recorded corneal changes similar to autoimmune endotheliopathy in four of ten patients with the diagnosis of pars planitis. These observations suggest that pars planitis may be an autoimmune process directed against the vitreous humor.
Topics: Adult; Autoimmune Diseases; Child; Child, Preschool; Corneal Diseases; Endothelium; Eye Diseases; Female; Humans; Male; Vitreous Body
PubMed: 3777084
DOI: 10.1016/0002-9394(86)90537-4 -
The British Journal of Ophthalmology Oct 2007To evaluate the frequency, phenotype and the potential function of CD57+ T cell subsets in patients with pars planitis.
AIM
To evaluate the frequency, phenotype and the potential function of CD57+ T cell subsets in patients with pars planitis.
METHODS
CD4+CD57+ and CD8+CD57+ T cells were quantitated in peripheral blood from 15 patients with pars planitis and 15 healthy controls. To evaluate the phenotype and potential function of CD57+ T cell subsets CCR7, CD27, CD28, CD45RA, CD45RO, intracellular IFN-gamma, IL-4, perforin and granzyme-A expression were assessed by flow cytometry.
RESULTS
CD57+ T cells subsets were increased in patients with pars planitis (p = 0.002). The majority of CD4+CD57+ T cells were CCR7-CD27-CD28-CD45RO+, while the most CD8+CD57+ T cells were CCR7-CD27-CD28-CD45RA+. The number of cells positive for intracellular IFN-gamma and IL-4 was higher in the CD57+ T cell populations. A greater number of CD8+CD57+ T cells than CD8+CD57- T cells were positive to perforin (p = 0.006) and granzyme-A (p = 0.01).
CONCLUSIONS
CD57+ T cells had a phenotype associated with peripheral memory (CCR7-CD27-CD28-). Cytokine production by CD57+ T cells suggests that these cells may play a role in helper cell regulation. High expression of intracellular proteins involved in cytotoxicity suggests that CD8+CD57+ T cells may play an effector role. Taken together, this study proposes that CD57+ T cells function as memory-effector T cell subsets during pars planitis pathogenesis.
Topics: Adolescent; CD28 Antigens; CD4-Positive T-Lymphocytes; CD57 Antigens; CD8-Positive T-Lymphocytes; Child; Female; Granzymes; Humans; Immunologic Memory; Immunophenotyping; Interferon-gamma; Interleukin-4; Leukocyte Common Antigens; Male; Membrane Glycoproteins; Pars Planitis; Perforin; Pore Forming Cytotoxic Proteins; Receptors, CCR7; Receptors, Chemokine; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 7
PubMed: 17475702
DOI: 10.1136/bjo.2007.116277 -
Indian Journal of Ophthalmology 2010Intermediate uveitis (IU) is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. In the Standardization of Uveitis Nomenclature... (Review)
Review
Intermediate uveitis (IU) is described as inflammation in the anterior vitreous, ciliary body and the peripheral retina. In the Standardization of Uveitis Nomenclature (SUN) working group's international workshop for reporting clinical data the consensus reached was that the term IU should be used for that subset of uveitis where the vitreous is the major site of the inflammation and if there is an associated infection (for example, Lyme disease) or systemic disease (for example, sarcoidosis). The diagnostic term pars planitis should be used only for that subset of IU where there is snow bank or snowball formation occurring in the absence of an associated infection or systemic disease (that is, "idiopathic"). This article discusses the clinical features, etiology, pathogenesis, investigations and treatment of IU.
Topics: Anti-Inflammatory Agents; Cryotherapy; Diagnosis, Differential; Fluorescein Angiography; Fundus Oculi; Humans; Immunity, Cellular; Immunosuppressive Agents; Microscopy, Acoustic; Ophthalmoscopy; Prognosis; T-Lymphocytes; Uveitis, Intermediate; Vitrectomy
PubMed: 20029143
DOI: 10.4103/0301-4738.58469 -
American Journal of Ophthalmology Sep 1987
Topics: Adolescent; Adult; Autoimmune Diseases; Child; Humans; Inflammation; Male; Middle Aged; Vitreous Body
PubMed: 3631195
DOI: 10.1016/0002-9394(87)90433-8 -
Bulletin of the New York Academy of... Mar 1988
Review
Topics: Adolescent; Adult; Child; Female; Humans; Male; Middle Aged; Uveitis
PubMed: 3073831
DOI: No ID Found -
Ophthalmic Genetics Mar 1995Pars planitis is an intraocular inflammatory disorder which usually affects children or young adults and is characterized by vitreous cells and debris ('snowballs'),...
Pars planitis is an intraocular inflammatory disorder which usually affects children or young adults and is characterized by vitreous cells and debris ('snowballs'), exudate, and 'snowbank' formation along the pars plana, variable periphlebitis, and cystoid macular edema. Although no inheritance pattern has been defined, familial cases of pars planitis have been reported. This report describes pars planitis in two sisters, one of whom had evidence of demyelinating disease at presentation. The literature on familial pars planitis is reviewed. To the author's knowledge this is the first case of familial pars planitis as the presenting sign of possible demyelinating disease.
Topics: Administration, Oral; Adult; Cavernous Sinus; Demyelinating Diseases; Female; Humans; Injections, Intravenous; Meningeal Neoplasms; Meningioma; Methylprednisolone; Pars Planitis; Prednisolone; Visual Acuity
PubMed: 7648038
DOI: 10.3109/13816819509057849 -
Therapeutic Advances in Ophthalmology 2021Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these... (Review)
Review
Pediatric uveitis accounts for up to 10% of all uveitis cases, so special attention must be paid to ensure early diagnosis as well as treatment and follow-up of these young patients in order to decrease the risk of possible ocular complications and consequently vision loss. Multimodal imaging has been an effective and important adjunct in the diagnoses and management of uveitis, especially in children. Reviewed here are the currently utilized modalities, advances, as well as their applications in juvenile idiopathic arthritis-associated uveitis, pars planitis, retinal vasculitis, tubulointerstitial nephritis and uveitis syndrome, Behçet disease, Blau syndrome, and Vogt-Koyanagi-Harada syndrome.
PubMed: 34901748
DOI: 10.1177/25158414211059244 -
Journal of Ophthalmology 2016Purpose. To evaluate the surgical outcome of scleral buckling (SB) in rhegmatogenous retinal detachment (RRD) patients associated with pars planitis. Methods....
Purpose. To evaluate the surgical outcome of scleral buckling (SB) in rhegmatogenous retinal detachment (RRD) patients associated with pars planitis. Methods. Retrospective review of RRD patients (32 eyes of pars planitis RRD and 180 eyes of primary RRD) who underwent SB. We compared primary and final anatomical success rates and visual outcomes between two groups. Results. Primary and final anatomical success were achieved in 25 (78.1%) and 31 (96.8%) eyes in the pars planitis RRD group and in 167 eyes (92.7%) and 176 eyes (97.7%) in primary RRD group, respectively. Both groups showed significant visual improvement (p < 0.001) and there were no significant differences in final visual acuity. Pars planitis RRD group was associated with higher rate of postoperative proliferative vitreoretinopathy (PVR) development (12.5% versus 2.8%, p = 0.031). Pars planitis and high myopia were significant preoperative risk factors and pseudophakia was borderline risk for primary anatomical failure after adjusting for various clinical factors. Conclusions. Pars planitis associated RRD showed inferior primary anatomical outcome after SB due to postoperative PVR development. However, final anatomical and visual outcomes were favorable. RRD cases associated with pars planitis, high myopia, and pseudophakia might benefit from different surgical approaches, such as combined vitrectomy and SB.
PubMed: 27688907
DOI: 10.1155/2016/4538193 -
Ocular Immunology and Inflammation Sep 2004Although the exact mechanisms that lead to uveitis are not entirely known, the role of cytokines in the pathogenesis of this disease has been shown to be important.... (Review)
Review
Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies.
INTRODUCTION
Although the exact mechanisms that lead to uveitis are not entirely known, the role of cytokines in the pathogenesis of this disease has been shown to be important. Prior studies described the presence of an array of cytokines in the intraocular fluid of patients with uveitis. Review of these studies indicate that Interleukin-6 (IL-6) is present, and animal data suggest the important role of IL-6 in the regulation of ophthalmologic immune responses.
PURPOSE
We investigated whether IL-6, TNF-alpha, IL-1 alpha, beta, IL-2 are present in the vitreous of patients with active intermediate and posterior uveitis.
METHODS
Vitreous specimens were collected from 23 eyes of patients with active intermediate and posterior uveitis who underwent diagnostic or therapeutic vitrectomies. TNF-alpha, IL-1 alpha and beta, IL-2 and IL-6 were measured by enzyme-linked immunosorbent assay. Eight vitreous fluid samples from eye bank eyes were used as control.
RESULTS
IL-6 was higher in the vitreous of patients with uveitis compared to control samples (p = 0.0119). No TNF-alpha, IL-2, IL1-alpha or beta was detected. The levels of IL-6 did not correlate with a specific clinical diagnosis, but patients with pars planitis and panuveitis had the highest levels (p = 0.58)
CONCLUSIONS
IL-6 is elevated in the vitreous of patients with active intermediate and posterior uveitis.
Topics: Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-1; Interleukin-2; Interleukin-6; Pars Planitis; Tumor Necrosis Factor-alpha; Uveitis, Posterior; Vitreous Body
PubMed: 15385196
DOI: 10.1080/092739490500282 -
Annals of Ophthalmology May 1981Pars planitis has rarely been noted to occur in more than one member of a family. We report the occurrence of this disorder in more than one member of two unrelated...
Pars planitis has rarely been noted to occur in more than one member of a family. We report the occurrence of this disorder in more than one member of two unrelated families. The affected members of one of these families included a 37-year-old woman and three of her six children. The affected members of the other family were two teenaged brothers. No specific cause for the familial clustering of pars planitis has been identified in the affected members of these families.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Fundus Oculi; HLA Antigens; Humans; Infant; Male; Middle Aged; Pedigree; Uveitis
PubMed: 7258948
DOI: No ID Found