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Cytokine & Growth Factor Reviews 2010The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models,... (Review)
Review
The experimental infectivity and excellent tolerance of some rodent autonomous parvoviruses in humans, together with their oncosuppressive effects in preclinical models, speak for the inclusion of these agents in the arsenal of oncolytic viruses under consideration for cancer therapy. In particular, wild-type parvovirus H-1PV can achieve a complete cure of various tumors in animal models and kill tumor cells that resist conventional anticancer treatments. There is growing evidence that H-1PV oncosuppression involves an immune component in addition to the direct viral oncolytic effect. This article summarizes the recent assessment of H-1PV antineoplastic activity in glioma, pancreatic ductal adenocarcinoma, and non-Hodgkin lymphoma models, laying the foundation for the present launch of a first phase I/IIa clinical trial on glioma patients.
Topics: Animals; Clinical Trials as Topic; Humans; Immunologic Factors; Neoplasms; Oncolytic Virotherapy; Oncolytic Viruses; Parvovirus
PubMed: 20211577
DOI: 10.1016/j.cytogfr.2010.02.011 -
Annual Review of Virology Sep 2019Parvoviruses are structurally simple viruses with linear single-stranded DNA genomes and nonenveloped icosahedral capsids. They infect a wide range of animals from... (Review)
Review
Parvoviruses are structurally simple viruses with linear single-stranded DNA genomes and nonenveloped icosahedral capsids. They infect a wide range of animals from insects to humans. Parvovirus B19 is a long-known human pathogen, whereas adeno-associated viruses are nonpathogenic. Since 2005, many parvoviruses have been discovered in human-derived samples: bocaviruses 1-4, parvovirus 4, bufavirus, tusavirus, and cutavirus. Some human parvoviruses have already been shown to cause disease during acute infection, some are associated with chronic diseases, and others still remain to be proven clinically relevant-or harmless commensals, a distinction not as apparent as it might seem. One initially human-labeled parvovirus might not even be a human virus, whereas another was originally overlooked due to inadequate diagnostics. The intention of this review is to follow the rocky road of emerging human parvoviruses from discovery of a DNA sequence to current and future clinical status, highlighting the perils along the way.
Topics: Communicable Diseases, Emerging; DNA, Viral; Genome, Viral; High-Throughput Nucleotide Sequencing; Humans; Parvoviridae Infections; Parvovirus; Sequence Analysis, DNA
PubMed: 31283445
DOI: 10.1146/annurev-virology-092818-015803 -
Infection, Genetics and Evolution :... Jun 2020Cutavirus is a new member of the Parvoviridae family. It was first discovered in 2016 through unbiased metagenomics performed on fecal samples collected from patients... (Review)
Review
Cutavirus is a new member of the Parvoviridae family. It was first discovered in 2016 through unbiased metagenomics performed on fecal samples collected from patients with diarrhea, and also in skin biopsies collected from patients with cutaneous T-cell lymphoma (CTCL, also known as mycosis fungoides). We have systematically reviewed the literature to describe the discovery, genomic organization, prevalence, and geographic distribution of cutavirus.
Topics: Biopsy; Diarrhea; Genetic Variation; Genome, Viral; Humans; Lymphoma, T-Cell, Cutaneous; Metagenome; Metagenomics; Molecular Epidemiology; Parvoviridae Infections; Parvovirus; Seroepidemiologic Studies
PubMed: 31917360
DOI: 10.1016/j.meegid.2020.104175 -
Virus Genes Oct 2010Parvoviridae, which are classified into two subfamilies Parvovirinae and Densovirinae, can infect both vertebrate and insects and are related to a wide range of diseases...
Parvoviridae, which are classified into two subfamilies Parvovirinae and Densovirinae, can infect both vertebrate and insects and are related to a wide range of diseases in insects, animals, and humans. In this report, several new parvoviruses were identified in swine sera collected in southeastern China. The sequence analyses showed that the parvoviruses detected in southeastern China formed a distinct sublineage within the subfamily Parvovirinae. Based on these results, we propose a novel parvovirus sublineage, Cnvirus, to describe these parvoviruses.
Topics: Animals; China; Cluster Analysis; DNA, Viral; Molecular Sequence Data; Parvoviridae Infections; Parvovirus; Phylogeny; Sequence Analysis, DNA; Sequence Homology; Serum; Swine; Swine Diseases
PubMed: 20574720
DOI: 10.1007/s11262-010-0506-3 -
Journal of Wildlife Diseases Jul 2001Various parvoviruses infect carnivores and can cause disease. In this review article the knowledge about infections of free-ranging or captive carnivores with the feline... (Review)
Review
Various parvoviruses infect carnivores and can cause disease. In this review article the knowledge about infections of free-ranging or captive carnivores with the feline parvoviruses, feline panleukopenia virus, and canine parvovirus, including the antigenic types CPV-2a and -2b, as well as Aleutian disease of mink virus and minute virus of canines are summarized. Particular emphasis is placed on description of the evolution of canine parvovirus which apparently involved wild carnivore hosts.
Topics: Animals; Animals, Wild; Carnivora; Cats; Disease Susceptibility; Dogs; Parvoviridae Infections; Parvovirus; Phylogeny; Vaccination
PubMed: 11504234
DOI: 10.7589/0090-3558-37.3.594 -
Emerging Infectious Diseases Jul 2018Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus,...
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been detected in feces of children with diarrhea. In addition, cutavirus has been detected in skin biopsy specimens of cutaneous T-cell lymphoma patients in France and in 1 melanoma patient in Denmark. We studied seroprevalences of IgG against bufavirus, tusavirus, and cutavirus in various populations (n = 840), and found a striking geographic difference in prevalence of bufavirus IgG. Although prevalence was low in adult populations in Finland (1.9%) and the United States (3.6%), bufavirus IgG was highly prevalent in populations in Iraq (84.8%), Iran (56.1%), and Kenya (72.3%). Conversely, cutavirus IgG showed evenly low prevalences (0%-5.6%) in all cohorts, and tusavirus IgG was not detected. These results provide new insights on the global distribution and endemic areas of protoparvoviruses.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antibodies, Viral; Cross Reactions; Female; Global Health; Humans; Immunoglobulin G; Male; Middle Aged; Parvoviridae Infections; Parvovirus; Population Surveillance; Young Adult
PubMed: 29912685
DOI: 10.3201/eid2407.172128 -
Transfusion Medicine (Oxford, England) Aug 2020
Topics: Anemia, Sickle Cell; Centers for Disease Control and Prevention, U.S.; Erythema Infectiosum; Hemoglobinopathies; Humans; Parvoviridae Infections; Parvovirus; Parvovirus B19, Human; United States
PubMed: 32567077
DOI: 10.1111/tme.12703 -
Virology Journal Oct 2021In line with the Latin expression "sed parva forti" meaning "small but mighty," the family Parvoviridae contains many of the smallest known viruses, some of which result... (Review)
Review
In line with the Latin expression "sed parva forti" meaning "small but mighty," the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in metagenomic viral discovery techniques have dramatically increased the identification of novel parvoviruses in both diseased and healthy individuals. While some of these discoveries have solved etiologic mysteries of well-described diseases in animals, many of the newly discovered parvoviruses appear to cause mild or no disease, or disease associations remain to be established. With the increased use of animal parvoviruses as vectors for gene therapy and oncolytic treatments in humans, it becomes all the more important to understand the diversity, pathogenic potential, and evolution of this diverse family of viruses. In this review, we discuss parvoviruses infecting vertebrate animals, with a special focus on pathogens of veterinary significance and viruses discovered within the last four years.
Topics: Animals; Metagenomics; Parvoviridae; Parvoviridae Infections; Parvovirus; Phylogeny
PubMed: 34689822
DOI: 10.1186/s12985-021-01677-y -
Methods in Molecular Biology (Clifton,... 1998
Review
Topics: Animals; DNA Primers; DNA, Viral; Electrophoresis, Agar Gel; Mice; Parvovirus; Polymerase Chain Reaction; Rodentia
PubMed: 9664500
DOI: 10.1385/0-89603-497-6:31 -
Archives of Virology Apr 2022Canine bufavirus (CBuV), a novel protoparvovirus of dogs that is associated with enteric and respiratory symptoms, has been reported only in Italy and China. The enteric...
Canine bufavirus (CBuV), a novel protoparvovirus of dogs that is associated with enteric and respiratory symptoms, has been reported only in Italy and China. The enteric prevalence of CBuV in India was investigated, and the nearly complete genome sequence (4292 bp) was amplified and reconstructed for one strain. A nucleotide sequence alignment indicated 93.42-98.81% identity to the other available CBuV sequences and 70.88-73.39% and 54.4-54.8% identity to human bufavirus and canine parvovirus 2 (CPV-2), respectively. The current strain is most closely related to Chinese CBuV strains, which together form an Asian lineage. This first report of the prevalence of CBuV in India emphasizes the need for further epidemiological surveillance.
Topics: Animals; Dog Diseases; Dogs; Parvoviridae Infections; Parvovirus; Parvovirus, Canine; Phylogeny
PubMed: 35235060
DOI: 10.1007/s00705-022-05398-7