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Cancer Research Sep 1985
Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies, Viral; Candidiasis, Oral; Child; Deltaretrovirus; Diagnosis, Differential; Female; HIV Antibodies; Humans; Infant; Pulmonary Fibrosis; Retroviridae Infections; Risk
PubMed: 2990704
DOI: No ID Found -
Journal of Acquired Immune Deficiency... Dec 2006A multidimensional pediatric AIDS severity score (PASS) has been developed for severity adjustment and as a predictive model for mortality in a pediatric HIV-infected...
BACKGROUND
A multidimensional pediatric AIDS severity score (PASS) has been developed for severity adjustment and as a predictive model for mortality in a pediatric HIV-infected population. While the prognostic value of PASS is relevant in the US setting, there is a need to develop a simpler model of PASS for use in resource-limited settings where CD4% values and HIV RNA levels may not be available to assess prognosis and guide treatment decisions.
METHODS
A Simple PASS model was developed including baseline weight percentile, WHO stage, symptoms, a general health rating, total lymphocyte count, packed-cell volume, and albumin measures from 1178 perinatally HIV-infected children enrolled into a prospective cohort study (PACTG 219). This prognostic model was then validated among 952 perinatally HIV-infected children enrolled in other PACTG research studies at the same sites. Survival estimates and Hazard Ratios (HR) were obtained using the Kaplan-Meier method and proportional hazards models, respectively. The predictive ability of the models was determined using Harrell's "C" statistic.
RESULTS
Of the clinical measures and assays considered in this study, weight percentile, WHO stage, symptomatology, general health rating, total lymphocyte count, packed-cell volume, and albumin were found to be predictive of mortality. The simple PASS model including only the simple clinical measures and assays was found to be predictive of mortality (C statistic = 0.852). Its discriminative ability for mortality was comparable to a model consisting of the Simple PASS plus CD4% (C statistic = 0.871).
CONCLUSION
The Simple PASS scoring system provides a reasonable alternative to CD4% values and HIV viral-load levels to assess prognosis and guide decisions about antiretroviral therapy initiation in resource-limited settings.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Anti-HIV Agents; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Severity of Illness Index
PubMed: 17003691
DOI: 10.1097/01.qai.0000242454.97650.72 -
Maryland Medical Journal (Baltimore,... Feb 1990
Topics: Acquired Immunodeficiency Syndrome; Child; Child Health Services; Child, Preschool; Humans; Maryland
PubMed: 2304387
DOI: No ID Found -
AIDS Patient Care and STDs Sep 2008The Pediatric AIDS Corps (PAC) are a group of physicians that were hired to provide clinical care and treatment to children and their families infected with HIV/AIDS and...
The Pediatric AIDS Corps (PAC) are a group of physicians that were hired to provide clinical care and treatment to children and their families infected with HIV/AIDS and to help educate local health care professionals in the management of children with HIV/AIDS located in the high prevalence areas of sub-Saharan Africa. Prior to their departure the PAC were required to participate in a 4-week educational training program that included travel and tropical medicine and HIV infections in children, teaching skills, bioethics, and good clinical practice in human research training. Evaluation of the program was done using a 50-question pretest/posttest design, a standard postcourse evaluation, and a PAC focus group follow-up. Fifty-two physicians were hired who had been trained in the following specialties: pediatrics (77%), medicine/pediatrics (9%), family medicine (8%), and internal medicine (6%). Posttest scores improved by a mean of 10 points for all PAC physicians (p < 0.001) but those that had been in Africa for 5 months or more prior to the course continued to score higher than the other participants. Reviewing the results by category demonstrated significant improvement in all areas (p < or = 0.002) except for general pediatrics for the HIV/AIDS infected patients (p = 0.124) and psychosocial issues (p = 0.376). Changes for the next training were implemented based upon the information obtained from the PAC focus group. The foundation provided by this educational course was an important beginning for the PAC physicians. Other groups providing specialized care to patients in developing countries might consider a similar educational program.
Topics: Acquired Immunodeficiency Syndrome; Africa South of the Sahara; Child; Education, Medical, Continuing; Female; Humans; International Cooperation; Male; Pediatrics
PubMed: 18754707
DOI: 10.1089/apc.2007.0230 -
Neonatal Network : NN Jun 1993
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Child; Child Advocacy; Child, Preschool; Female; Humans; Infant; Pain Management; United States; Zidovudine
PubMed: 8510628
DOI: No ID Found -
American Journal of Public Health Apr 1988To assess the degree of house officers' concerns about acquiring AIDS (acquired immunodeficiency syndrome) from their patients, we surveyed 263 medical and pediatric...
To assess the degree of house officers' concerns about acquiring AIDS (acquired immunodeficiency syndrome) from their patients, we surveyed 263 medical and pediatric interns and residents in four housestaff training programs affiliated with seven New York City hospitals with large AIDS patient populations; 258 questionnaires (98 per cent) were returned. Thirty-six per cent of medical and 17 per cent of pediatric house officers reported percutaneous exposures to needles contaminated with blood of AIDS patients. Forty-eight per cent of medical and 30 per cent of pediatric house officers reported a moderate to major concern about acquiring AIDS from their patients. Greater concern about personal risk was noted in those house officers who were earlier in their residency training, who reported having treated a greater number of AIDS patients, and who were in medicine rather than pediatrics programs. Twenty-five per cent of all respondents reported that they would not continue to care for AIDS patients if given a choice. The results demonstrate a substantial degree of concern about acquiring AIDS among house officers caring for AIDS patients and suggest the need for housestaff program administrators for formally address these concerns.
Topics: Acquired Immunodeficiency Syndrome; Adult; Attitude of Health Personnel; Female; HIV Seropositivity; Humans; Internship and Residency; Male; Mandatory Programs; Moral Obligations; New York City; Occupational Diseases; Pediatrics
PubMed: 3348474
DOI: 10.2105/ajph.78.4.455 -
Developmental Medicine and Child... Oct 1985
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Child; Child, Preschool; Genetic Diseases, Inborn; Health Education; Humans; Infant; Infant, Newborn; Pediatrics; Physician's Role; Research; Role
PubMed: 4065433
DOI: 10.1111/j.1469-8749.1985.tb14126.x -
Journal of General Internal Medicine Jul 2020
Topics: Humans; Acquired Immunodeficiency Syndrome; Cohort Studies; Randomized Controlled Trials as Topic
PubMed: 31768903
DOI: 10.1007/s11606-019-05554-x -
The Journal of School Health Mar 1986This paper reviews the epidemiological, clinical, and public health aspects of Acquired Immunodeficiency Syndrome (AIDS) in the pediatric population. Evidence...
This paper reviews the epidemiological, clinical, and public health aspects of Acquired Immunodeficiency Syndrome (AIDS) in the pediatric population. Evidence establishing modes of transmission is emphasized. Guidelines are presented to assist school staff in the educational management of children infected with the AIDS virus.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Child; Child, Preschool; Ethics, Medical; Faculty; Health Education; Hepatitis B; Humans; Legislation, Medical; New York City; Schools
PubMed: 3634136
DOI: 10.1111/j.1746-1561.1986.tb05704.x -
AIDS (London, England) 1988
Review
Topics: Acquired Immunodeficiency Syndrome; Epidemiologic Methods; Female; HIV Antibodies; HIV Core Protein p24; Humans; Infant Mortality; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Infectious; Retroviridae Proteins
PubMed: 3147684
DOI: 10.1097/00002030-198800001-00012