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Developmental Dynamics : An Official... May 2011Genes expressed in the somatopleuric mesoderm, the embryonic domain giving rise to the vertebrate pelvis, appear important for pelvic girdle formation. Among such genes,...
Genes expressed in the somatopleuric mesoderm, the embryonic domain giving rise to the vertebrate pelvis, appear important for pelvic girdle formation. Among such genes, Pbx family members and Emx2 were found to genetically interact in hindlimb and pectoral girdle formation. Here, we generated compound mutant embryos carrying combinations of mutated alleles for Pbx1, Pbx2, and Pbx3, as well as Pbx1 and Emx2, to examine potential genetic interactions during pelvic development. Indeed, Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation. We show that, in compound Pbx1;Pbx2 and Pbx1;Emx2 mutants, pelvic mesenchymal condensation is markedly perturbed, indicative of an upstream control by these homeoproteins. We establish that expression of Tbx15, Prrx1, and Pax1, among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants. Lastly, we identify potential Pbx1-Emx2-regulated enhancers for Tbx15, Prrx1, and Pax1, using bioinformatics analyses.
Topics: Animals; Computational Biology; Female; Gene Expression Regulation, Developmental; Homeodomain Proteins; In Situ Hybridization; Male; Mice; Paired Box Transcription Factors; Pelvis; Pre-B-Cell Leukemia Transcription Factor 1; Proto-Oncogene Proteins; T-Box Domain Proteins; Transcription Factors
PubMed: 21455939
DOI: 10.1002/dvdy.22617 -
Cladistics : the International Journal... Jun 2023The morphology of paired fins is commonly overlooked in morphological studies, particularly the pelvic girdle and fins. Consequently, previous phylogenetic studies...
The morphology of paired fins is commonly overlooked in morphological studies, particularly the pelvic girdle and fins. Consequently, previous phylogenetic studies incorporating morphological data used few skeletal characters from this complex. In this paper, the phylogenetic significance of pelvic articular characters for elasmobranchs is discussed in light of the morphological variation observed in 130 species, the most comprehensive study exploring the morphology of the pelvic girdle done so far. The 10 morphological characters proposed herein for the pelvic articulation were incorporated into a molecular matrix of NADH2 sequences and submitted to an analysis of maximum parsimony employing extended implied weighting. The most stable tree was selected based on the distortion coefficients, SPR distances (subtree pruning and regrafting) and fit values. Some of the striking synapomorphies recovered within elasmobranchs include the presence of an articular surface for the first enlarged pelvic radial supporting Elasmobranchii and the pelvic articular region for the basipterygium extending from the posterolatral margin of the pelvic girdle over its lateral surface in Echinorhinus + Hexanchiformes. Additionally, the proposed characters and their distributions are discussed considering the relationships recovered and also compared with previous morphological and molecular phylogenetic hypotheses.
Topics: Animals; Phylogeny; Pelvis; Sacrococcygeal Region; Sharks
PubMed: 36856203
DOI: 10.1111/cla.12528 -
Spine Jun 2007A cohort study.
STUDY DESIGN
A cohort study.
OBJECTIVE
To investigate the possible association of lumbopelvic pain and postpartum depression and differences in the prevalence of depressive symptoms among women without lumbopelvic pain and women classified as having pelvic girdle pain (PGP) and/or lumbar pain.
SUMMARY OF BACKGROUND DATA
Lumbopelvic pain and depression are common pregnancy complications, but their comorbidity has rarely been evaluated and has not been studied in relation to subgroups of lumbopelvic pain.
METHODS
In a cohort of consecutively enrolled pregnant women, the Edinburgh Postnatal Depression Scale was used to evaluate depressive symptoms at 3 months postpartum, applying a primary screening cutoff of > or =10 and a cutoff of > or =13 for probable depression. Women were classified into lumbopelvic pain subgroups by means of mechanical assessment of the lumbar spine, standard history, pelvic pain provocation tests, a pain drawing, and the active straight leg raising test.
RESULTS
The postpartum cohort (n = 267) comprised 180 (67%) women without lumbopelvic pain, 44 (16%) with PGP, 29 (11%) with lumbar pain, and 14 (5%) with combined PGP and lumbar pain. Applying a cutoff of > or =10, postpartum depressive symptoms were more prevalent in women with lumbopelvic pain (27 of 87, 31%; 95% confidence interval, 26%-36%) than in women without lumbopelvic pain (17 of 180, 9%; 95% confidence interval, 5%-13%; P < 0.001). The comorbidity of lumbopelvic pain and depressive symptoms was 10%. Depressive symptoms were more prevalent in women with lumbar pain versus women without lumbopelvic pain when applying cutoffs of > or =10 or > or =13 (P < or = 0.002); whereas for women with PGP, this comparison was significant only at the screening level of > or =10 (P = 0.01).
CONCLUSIONS
Postpartum depressive symptoms were 3 times more prevalent in women having lumbopelvic pain than in those without. This comorbidity highlights the need to consider both symptoms in treatment strategies.
Topics: Adult; Cohort Studies; Comorbidity; Depression, Postpartum; Female; Humans; Logistic Models; Low Back Pain; Lumbar Vertebrae; Pelvis; Pregnancy; Pregnancy Complications; Prevalence
PubMed: 17545912
DOI: 10.1097/BRS.0b013e318060a673 -
Obstetrical & Gynecological Survey Mar 2009About 45% of all pregnant women and 25% of all women postpartum suffer from pelvic girdle pain and/or low back pain (PLPP). It has been suggested that increased motion... (Review)
Review
About 45% of all pregnant women and 25% of all women postpartum suffer from pelvic girdle pain and/or low back pain (PLPP). It has been suggested that increased motion of the three joints in the pelvic ring is one of the causes of PLPP. However, in spite of the availability of high technology the relation between enlarged motion of the pelvic joints and pain remains unclear. This article presents 14 studies on this topic, of which 8 are of sufficient quality to draw conclusions. The conclusion is that, during the last months of pregnancy and the first 3 weeks after delivery, motion of the pelvic girdle joints is 32-68% larger in patients with PLPP than in healthy controls. The overlap in the range of symphyseal motion between PLPP patients and healthy controls is too large to use motion as a diagnostic tool in individual cases. The findings support the idea that enlarged motion is one of the factors that causes PLPP and justifies treatment with measures to reduce this motion.
Topics: Female; Humans; Joints; Low Back Pain; Pelvic Pain; Pelvis; Pregnancy; Pregnancy Complications; Range of Motion, Articular
PubMed: 19228440
DOI: 10.1097/OGX.0b013e3181950f1b -
Disability and Rehabilitation Dec 2018To explore how women experience living with long-term pregnancy-related pelvic girdle pain.
PURPOSE
To explore how women experience living with long-term pregnancy-related pelvic girdle pain.
MATERIALS AND METHODS
Nine women with persistent pregnancy-related pelvic girdle pain of 2-13 years were recruited by means of purposive sampling from long-term follow-up studies. The women were 28-42 years of age and had given birth to 2-3 children. Audio-taped in-depth interview with open-ended questions were used with the guiding question 'How do you experience living with pregnancy-related pelvic girdle pain?'. The Empirical Phenomenological Psychological method was chosen for analysis.
RESULTS
The pregnancy-related pelvic girdle pain syndrome has a profound impact on everyday life for many years after pregnancy. Three constituents were identified as central to the experience of living with pregnancy-related pelvic girdle pain: (1) the importance of the body for identity, (2) the understanding of pain, and (3) stages of change. The manner in which the women experienced their pain was interpreted in terms of two typologies: the ongoing struggle against the pain, and adaptation and acceptance.
CONCLUSION
The participants' narratives highlighted that the pain led to severe functional limitations that threatened their capability to perform meaningful daily activities, and interfered with their sense of identity. It appears essential to meet with each patient individually and to manage long-term pregnancy-related pelvic girdle pain as a pain syndrome. IMPLICATIONS FOR REHABILITATION Chronic pregnancy-related pelvic girdle pain • Pregnancy-related pelvic girdle pain impairs women's capacity to perform meaningful activities of daily life for many years after pregnancy. • The participants' narratives highlighted that the pain interfered with their sense of identity. • It appears essential to meet with each patient individually and to manage long-term pregnancy-related pelvic girdle pain as a pain syndrome.
Topics: Activities of Daily Living; Adaptation, Psychological; Adult; Chronic Pain; Female; Follow-Up Studies; Humans; Interview, Psychological; Pelvic Girdle Pain; Pregnancy; Pregnancy Complications
PubMed: 28835130
DOI: 10.1080/09638288.2017.1368724 -
International Urogynecology Journal Jul 2012The aim of this study is to determine pelvic floor muscle (PFM) function in second trimester women with and without pelvic girdle pain (PGP).
INTRODUCTION AND HYPOTHESIS
The aim of this study is to determine pelvic floor muscle (PFM) function in second trimester women with and without pelvic girdle pain (PGP).
METHODS
Fifty-five pregnant women with and without PGP were recruited in the second trimester who met inclusion for self-reported pain. Vaginal examination was performed assessing superficial and deep PFM tenderness, contract/relax patterns, and muscle strength.
RESULTS
Fifty-one patients (26 with PGP and 25 without) were included in the final analyses. Significantly more patients in the PGP group had bilateral levator ani and obturator internus tenderness compared with the no pain group (Fisher's exact test (FET) P < 0.001). No other significant group differences were found.
CONCLUSION
There is an association between PGP and deep but not superficial PFM tenderness in pregnancy. Lack of accompanying PFM dysfunction in PGP during pregnancy may reflect pain duration.
Topics: Adult; Cross-Sectional Studies; Female; Humans; Low Back Pain; Middle Aged; Pain Measurement; Pelvic Floor; Pelvic Girdle Pain; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Prospective Studies; Surveys and Questionnaires
PubMed: 22290191
DOI: 10.1007/s00192-011-1658-y -
Indian Pediatrics Nov 2003The best known muscular dystrophies are X-linked dystrophinopathies. A clinically and genetically heterogeneous group presenting with weakness of the pelvic and shoulder...
The best known muscular dystrophies are X-linked dystrophinopathies. A clinically and genetically heterogeneous group presenting with weakness of the pelvic and shoulder girdles is that of the limb-girdle muscular dystrophies (LGMDs). Sarcoglycanopathies (SGPs) are autosomal recessive LGMDs. We report a rare case of primary gamma-sarcoglycanopathy (SGP) which emphasizes the evolving concept of dystrophinopathy to sarco-glycanopathy.
Topics: Biopsy, Needle; Child; Cytoskeletal Proteins; Genes, Recessive; Humans; Immunohistochemistry; India; Male; Muscle, Skeletal; Muscular Dystrophies; Prognosis; Sarcolemma
PubMed: 14660840
DOI: No ID Found -
How do Australian women cope with pelvic girdle pain during pregnancy? A qualitative study protocol.BMJ Open Jul 2018Pelvic girdle pain is commonly experienced during pregnancy and results in significant physical, psychosocial and work-related challenges. Few studies have investigated...
INTRODUCTION
Pelvic girdle pain is commonly experienced during pregnancy and results in significant physical, psychosocial and work-related challenges. Few studies have investigated the lived experiences of pregnant women with pelvic girdle pain and their coping strategies. There is a need to develop a greater understanding of this prevalent condition among Australian women. Thus, this study seeks to gain information about the impact of pelvic girdle pain on daily life and how women cope with this condition during pregnancy.
METHODS AND ANALYSIS
A qualitative research design, situated within a phenomenological framework, is adopted. The participants will be invited to describe their lived experiences of pregnancy-related pelvic girdle pain, the impact on their daily life and the strategies they use to cope with the condition. A stratified purposive sample will be undertaken to ensure the sample provides information-rich cases representative of women with pregnancy-related pelvic girdle pain. Face-to-face, individual, semistructured interviews will be conducted with participants at Westmead Hospital, Sydney, Australia. A solicited diary will be offered to any participants who may find attending the interview difficult. All participants will also be invited to attend a focus group session. The different methods of data collection used in this study will allow for triangulation, thereby increasing the trustworthiness of findings.
ETHICS AND DISSEMINATION
Ethical approval has been granted by the Human Research Ethics Committees of Westmead Hospital, Sydney, and Western Sydney University, Sydney. Dissemination of results will be via journal articles and conference presentations.
Topics: Adaptation, Psychological; Australia; Clinical Protocols; Female; Focus Groups; Humans; Pelvic Girdle Pain; Pregnancy; Pregnancy Complications; Qualitative Research
PubMed: 30012793
DOI: 10.1136/bmjopen-2018-022332 -
Pain Practice : the Official Journal of... Feb 2012Chronic pelvic pain is defined as the presence of pain in the pelvic girdle region for over a 6-month period and can arise from the gynecologic, urologic,... (Review)
Review
Chronic pelvic pain is defined as the presence of pain in the pelvic girdle region for over a 6-month period and can arise from the gynecologic, urologic, gastrointestinal, and musculoskeletal systems. As 15% of women experience pelvic pain at some time in their lives with yearly direct medical costs estimated at $2.8 billion, effective evaluation and management strategies of this condition are necessary. This merits a thorough discussion of a systematic approach to the evaluation of chronic pelvic pain conditions, including a careful history-taking and clinical examination. The challenge of accurately diagnosing chronic pelvic pain resides in the degree of peripheral and central sensitization of the nervous system associated with the chronicity of the symptoms, as well as the potential influence of the affective and biopsychosocial factors on symptom development as persistence. Once the musculoskeletal origin of the symptoms is identified, a clinical examination schema that is based on the location of primary onset of symptoms (lumbosacral, coccygeal, sacroiliac, pelvic floor, groin or abdominal region) can be followed to establish a basis for managing the specific pain generator(s) and manage tissue dysfunction.
Topics: Chronic Disease; Chronic Pain; Female; Humans; Musculoskeletal Diseases; Pelvic Floor; Pelvic Pain; Physical Examination; Sacrococcygeal Region; Sacroiliac Joint
PubMed: 21615678
DOI: 10.1111/j.1533-2500.2011.00465.x -
Manual Therapy Dec 2010The objective of this prospective cohort study was to examine how results of clinical tests on women with pelvic girdle pain (PGP) in late pregnancy were associated with...
The objective of this prospective cohort study was to examine how results of clinical tests on women with pelvic girdle pain (PGP) in late pregnancy were associated with disability and pain intensity 12 weeks postpartum controlling for socio-demographical and psychological factors. Out of the 283 women clinically examined in gestation week 30, 179 were considered afflicted from PGP and constituted the study sample. Potential risk factors were assessed by questionnaires (at inclusion and in gestation week 30) and clinical examination in gestation week 30. The clinical examination included pain provocation tests for the pelvis as well as the active straight leg raise test. We used pain intensity and disability (disability rating index, DRI) as response variables, derived from questionnaires 12 weeks postpartum. Using multivariable linear regression analyses, sum of pain provocation tests and pre-pregnancy low back pain (LBP) were significantly associated with DRI 12 weeks postpartum. Furthermore, sum of pain provocation tests and number of pain sites were significantly associated with pain intensity. In conclusion, we found that when including results of clinical tests as risk factors together with socio-demographical and psychological factors in multivariable regression models, the clinical risk factors are the ones that remain significant. These results are of clinical importance because they seem to have the potential to identify women with a poor prognosis.
Topics: Adult; Cohort Studies; Comorbidity; Disability Evaluation; Female; Humans; Multivariate Analysis; Norway; Pain Measurement; Pelvic Pain; Postpartum Period; Pregnancy; Pregnancy Complications; Prenatal Diagnosis; Prognosis; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Young Adult
PubMed: 20621546
DOI: 10.1016/j.math.2010.05.007