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Seminars in Arthritis and Rheumatism May 1986The discovery of D-penicillamine and its uses in medicine are reviewed. Chemical-physical properties are discussed, and the molecular structure of D-penicillamine and... (Comparative Study)
Comparative Study Review
The discovery of D-penicillamine and its uses in medicine are reviewed. Chemical-physical properties are discussed, and the molecular structure of D-penicillamine and several of its reaction products are illustrated. Examples of its three main types of biochemical reactions--sulfhydryl-disulfide exchange, thiazolidine formation, and metal chelation are included. Trials of D-penicillamine in RA patients are reviewed critically. The administration of the drug is discussed in detail, including dosages, clinical and laboratory responses, patterns of adverse side effects or toxicity, drug-induced autoimmune diseases, indications and contraindications, and the monitoring and management of patients.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Drug Eruptions; Gold Sodium Thiomalate; Hematologic Diseases; Humans; Kidney Diseases; Kinetics; Molecular Conformation; Penicillamine; Rheumatic Diseases; Scleroderma, Systemic; Spondylitis; Structure-Activity Relationship; Taste Disorders
PubMed: 2940684
DOI: 10.1016/0049-0172(86)90022-3 -
Arthritis and Rheumatism Feb 1979
Topics: Arthritis, Rheumatoid; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Penicillamine
PubMed: 420710
DOI: 10.1002/art.1780220214 -
The Australian Nurses' Journal. Royal... Jun 1983
Topics: Humans; Penicillamine
PubMed: 6556051
DOI: No ID Found -
Methods in Enzymology 1987
Topics: Amino Acids; Autoanalysis; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Indicators and Reagents; Penicillamine
PubMed: 3657535
DOI: 10.1016/0076-6879(87)43035-8 -
The Medical Letter on Drugs and... Jun 1967
Topics: Cystinuria; Gold; Hepatolenticular Degeneration; Humans; Lead Poisoning; Penicillamine
PubMed: 6035365
DOI: No ID Found -
Annals of the Rheumatic Diseases Jun 1979Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded...
Information has been collected on 10 patients, 9 with marrow depression and 1 in whom the diagnosis was presumed. Six of the 10 patients died. The sequentially recorded blood counts on at least 5 of the patients showed a downward trend of the white cell and platelet counts while D-penicillamine was still being administered. One patient suddenly developed leucopenia and thrombocytopenia with a streptococcal septicaemia.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Cell Count; Bone Marrow Diseases; Female; Humans; Male; Middle Aged; Penicillamine; Time Factors
PubMed: 485580
DOI: 10.1136/ard.38.3.232 -
British Medical Journal Mar 1977
Topics: Abnormalities, Drug-Induced; Cystinuria; Female; Humans; Infant, Newborn; Penicillamine; Pregnancy; Teratogens
PubMed: 851752
DOI: 10.1136/bmj.1.6064.838-b -
The American Journal of Gastroenterology Dec 1987
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Penicillamine; Pulmonary Fibrosis
PubMed: 3687909
DOI: No ID Found -
Clinical Pharmacology and Therapeutics Sep 1981The kinetic characteristics of penicillamine are reported in four fasting subjects after four oral doses each. On late test days, tow of the subjects received an... (Comparative Study)
Comparative Study
The kinetic characteristics of penicillamine are reported in four fasting subjects after four oral doses each. On late test days, tow of the subjects received an additional single dose 30 min after a large breakfast. On subject originally included in the study had to drop out because of gastrointestinal disturbances following each of two single doses of penicillamine. The fasting plasma levels of penicillamine observed in this study displayed an unusual double peak in the plasma levels after single doses. Individual subjects had consistent plasma level patterns for each of the four single doses but there was marked intersubject variability in patterns and kinetic parameters. The half-life of unchanged penicillamine ranged from 1.66 to 3.15 hr and the apparent plasma clearance ranged from 530 to 2300 ml/min. The administration of penicillamine following a large breakfast caused a reduction in the area under the penicillamine plasma concentration-time curve corresponding to a decrease in the extent of absorption of unchanged penicillamine.
Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eating; Fasting; Female; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Penicillamine
PubMed: 7273605
DOI: 10.1038/clpt.1981.180 -
Proceedings of the Royal Society of... Feb 1977
Topics: Arthritis, Rheumatoid; Gold; Humans; Penicillamine
PubMed: 859814
DOI: No ID Found