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Lancet (London, England) Jul 1982
Topics: Drug Evaluation; Hepatolenticular Degeneration; Humans; Penicillamine
PubMed: 6124700
DOI: 10.1016/s0140-6736(82)90356-7 -
Reumatizam 1976
Topics: Arthritis, Rheumatoid; Humans; Penicillamine; Thrombocytopenia
PubMed: 981828
DOI: No ID Found -
Advances in Experimental Medicine and... 1977The pharmacological and therapeutic action of penicillamine are very largely explained by its ability to chelate metal ions and take part in oxidation-reduction... (Review)
Review
The pharmacological and therapeutic action of penicillamine are very largely explained by its ability to chelate metal ions and take part in oxidation-reduction reactions, sulfhydryl-disulfide interchange, and nucleophilic addition. Effects of penicillamine on particular enzymes are explained by its chemical properties. Possible interactions with amino acids, tissue proteins, food constituents, and intermediates in the metabolism and biosynthesis of sulfur containing amino acids are discussed.
Topics: Animals; Chemical Phenomena; Chemistry; Copper; Disulfides; Drug Synergism; Male; Mercury Poisoning; Mice; Penicillamine; Quinones; Rats; Structure-Activity Relationship
PubMed: 333874
DOI: 10.1007/978-1-4757-9113-6_36 -
British Medical Journal Aug 1979
Topics: Acute Disease; Arthritis, Rheumatoid; Colitis; Female; Humans; Middle Aged; Penicillamine
PubMed: 486938
DOI: 10.1136/bmj.2.6186.367 -
Proceedings of the Royal Society of... 1977In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are...
In a study using 14C-D-penicillamine in a normal subject only 50% of the D-penicillamine was absorbed from the gut. The major urinary metabolites are cysteine-penicillamine and penicillamine disulphide. S-methyl-D-penicillamine is the only biochemically transformed metabolite so far identified.
Topics: Amino Acids; Biotransformation; Cysteine; Feces; Half-Life; Humans; Penicillamine
PubMed: 122676
DOI: No ID Found -
Proceedings of the Royal Society of... 1977
Review
Topics: Animals; Chelating Agents; Chemical Phenomena; Chemistry, Physical; Disulfides; Humans; Penicillamine; Quinones; Sulfhydryl Compounds; Thiazoles
PubMed: 122675
DOI: No ID Found -
Acta Medica Scandinavica 1981
Topics: Animals; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Humans; Kinetics; Penicillamine; Sulfhydryl Compounds
PubMed: 7234501
DOI: 10.1111/j.0954-6820.1981.tb11585.x -
British Medical Journal Jan 1978
Topics: Arthritis, Rheumatoid; Humans; Penicillamine
PubMed: 620222
DOI: 10.1136/bmj.1.6106.131 -
Orthopedic Nursing 1991
Topics: Humans; Nursing Care; Orphan Drug Production; Penicillamine; United States
PubMed: 2020501
DOI: 10.1097/00006416-199103000-00013 -
The Journal of Pediatrics Oct 1977Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases...
Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases of solubilized arsenic trioxide poisoning in Navajo Indian children and one case of sodium arsenate ingestion in an infant. One fatality occurred during dimercaprol therapy prior to initiation of therapy with D-penicillamine. Three survivors were treated with 2.3-dimercaprol intramuscularly and with oral D-penicillamine. The use of D-penicillamine in arsenic poisoning has not been generally appreciated. Excretion data from the three children are presented which document the effectiveness of D-penicillamine, administered orally in four daily doses of 25 mg/kg/dose, in the therapy of arsenic intoxication. Excretion data for the trace metals, zinc and copper, during D-penicillamine chelation therapy are also reported.
Topics: Acute Disease; Arsenic Poisoning; Child, Preschool; Dimercaprol; Humans; Infant; Male; Penicillamine
PubMed: 908992
DOI: 10.1016/s0022-3476(77)80528-3