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Singapore Medical Journal Mar 1964
Topics: Drug Resistance; Drug Resistance, Microbial; Ethylenediamines; Gonorrhea; Humans; Neisseria gonorrhoeae; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillins; Procaine; Singapore; Statistics as Topic; Urethritis
PubMed: 14150344
DOI: No ID Found -
Therapie Der Gegenwart Nov 1963
Topics: Ampicillin; Humans; Methicillin; Oxacillin; Penicillin G; Penicillin V; Penicillins
PubMed: 14112736
DOI: No ID Found -
Schweizerische Medizinische... Apr 1968
Topics: Ampicillin; Cephalosporins; Chemical Phenomena; Chemistry; Cloxacillin; Drug Hypersensitivity; Endocarditis, Bacterial; Humans; Infections; Methicillin; Oxacillin; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin Resistance; Penicillin V; Penicillins; Skin Tests
PubMed: 4971632
DOI: No ID Found -
Medecine Tropicale : Revue Du Corps de... 2000
Topics: Humans; Injections, Intramuscular; Patient Selection; Penicillin G Benzathine; Tissue Distribution
PubMed: 11100435
DOI: No ID Found -
Pharmazie in Unserer Zeit 2006
Review
Topics: Bacteria; Carbapenems; Cephalosporins; Humans; Penicillin G; Penicillins; Structure-Activity Relationship; beta-Lactams
PubMed: 17009784
DOI: 10.1002/pauz.200600186 -
[ON NEW RESULTS AND POSSIBILITIES IN PENICILLIN RESEARCH AND THERAPY. ON SEMISYNTHETIC PENICILLINS].Die Pharmazie Feb 1964
Review
Topics: Ampicillin; Chemistry, Pharmaceutical; Drug Resistance, Microbial; Drug Therapy; Ethylenediamines; Methicillin; Mice; Oxacillin; Penicillin G; Penicillin G Benzathine; Penicillin Resistance; Penicillin V; Penicillins; Research
PubMed: 14226699
DOI: No ID Found -
La Revue Du Praticien Jan 1988
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Pediatric Clinics of North America Aug 1963
Topics: Child; Ethylenediamines; Humans; Methicillin; Oxacillin; Pediatrics; Penicillin G; Penicillin G Benzathine; Penicillin G Procaine; Penicillin V; Penicillins; Pharmacology; Procaine; Toxicology
PubMed: 14145017
DOI: 10.1016/s0031-3955(16)31449-3 -
Infection Apr 2023The purpose of this study was to assess the clinical outcomes of adults with invasive meningococcal disease (IMD) and to compare the outcomes of patients with IMD caused...
PURPOSE
The purpose of this study was to assess the clinical outcomes of adults with invasive meningococcal disease (IMD) and to compare the outcomes of patients with IMD caused by a penicillin susceptible isolate (minimum inhibitory concentration (MIC) ≤ 0.06 mg/L) with patients with IMD caused by an isolate with reduced penicillin susceptibility (MIC > 0.06 mg/L). We also assessed the outcomes of patients with IMD caused by an isolate with reduced penicillin susceptibility who were treated exclusively with intravenous (IV) benzylpenicillin.
METHODS
Retrospective study of all culture positive IMD in adult patients (age ≥ 15 years) in the Auckland region from 2004 to 2017.
RESULTS
One hundred and thirty-nine patients were included; 94 had penicillin susceptible isolates (88 cured, 6 died), and 45 had an isolate with reduced penicillin susceptibility (41 cured, 1 possible relapse, 3 died). The median benzylpenicillin/ceftriaxone treatment duration was 3 days for both groups. There was no difference in the patient outcomes of both groups. Eighteen patients with IMD caused by an isolate with reduced penicillin susceptibility received benzylpenicillin alone and were cured.
CONCLUSIONS
This study provides further support to existing data that has shown that short duration IV beta-lactam treatment is effective for IMD in adults. Only a small number of patients with meningitis caused by an isolate with reduced penicillin susceptibility received benzylpenicillin alone, limiting its evaluation. For Neisseria meningitidis meningitis, we recommend ceftriaxone as empiric treatment and as definitive treatment when this is caused by an isolate with reduced penicillin susceptibility.
Topics: Adult; Humans; Adolescent; Penicillins; Ceftriaxone; Retrospective Studies; Meningococcal Infections; Neisseria meningitidis; Penicillin G; Microbial Sensitivity Tests; Meningitis, Meningococcal
PubMed: 35982367
DOI: 10.1007/s15010-022-01897-6 -
The Journal of Allergy and Clinical... Jun 2020The positive rate and pattern of penicillin skin test (PST) has been reported to be decreasing and changing. Previous studies differ about which penicillin component is...
BACKGROUND
The positive rate and pattern of penicillin skin test (PST) has been reported to be decreasing and changing. Previous studies differ about which penicillin component is the dominant component in positive PST result.
OBJECTIVE
To characterize past and current PST patterns to determine whether different determinants in PST have changed over time.
METHODS
A retrospective review of electronic medical records (January 2001-December 2017) was performed for patients who underwent PST. Data were divided into 4 cohorts to see whether trends occurred over time. The cohorts were divided as follows: cohort 1 (2001-2005), cohort 2 (2006-2010), cohort 3 (2011-2015), and cohort 4 (2016-2017).
RESULTS
A total of 30,883 patients underwent PST with the following breakdowns per cohort: cohort 1, 6,536; cohort 2, 10,372; cohort 3, 10,640; and cohort 4, 3,335. Of these, 329 patients (1.0%) had a positive PST result with a wheal of 3 × 3 mm or greater, with 110 in cohort 1, 130 in cohort 2, 67 in cohort 3, and 22 in cohort 4, whereas 170 patients (0.5%) had a positive PST result with a wheal of 5 × 5 mm or greater, with 54 in cohort 1, 72 in cohort 2, 34 in cohort 3, and 10 in cohort 4. When the positive PST rates of cohort 2 (1.25%), cohort 3 (0.6%), and cohort 4 (0.6%) were compared with those of cohort 1 (1.7%), there was a significant decrease in positive PST rates (P = .0278; P < .0001; P < .0001, respectively). When cohort 1 positive rate to benzylpenicillin polylysine among the positive PST (wheal of 3 × 3 mm or greater) was compared with those of the other cohorts (cohorts 2-4), the percent positive of benzylpenicillin polylysine in PST was 27% compared with 21% (P = .38), 34% (P = .5), and 18% (P = .6), respectively. When the positive PST result was defined as a wheal of 5 × 5 mm or greater, the positive rate for benzylpenicillin polylysine in PST increased over time (cohort 2: 22%, P = .8; cohort 3: 32%, P = .3; cohort 4: 40%, P = .264) compared with cohort 1 (19%).
CONCLUSIONS
Positive PST rate is decreasing. We demonstrate that despite benzylpenicillin polylysine solely positive rates remaining relatively stable, the minor penicillin determinants and amoxicillin play an important role in PST and their adoption into standard protocol for routine PST should be considered.
Topics: Amoxicillin; Drug Hypersensitivity; Humans; Penicillin G; Penicillins; Retrospective Studies; Skin Tests
PubMed: 32006722
DOI: 10.1016/j.jaip.2020.01.039