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The Journal of Urology Apr 1994Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis are uncommon disorders of the anogenital skin that may be confused with a variety of other lesions.... (Review)
Review
Bowen's disease, erythroplasia of Queyrat and bowenoid papulosis are uncommon disorders of the anogenital skin that may be confused with a variety of other lesions. While all appear histologically as carcinoma in situ and are strongly associated with human papillomavirus infection, only Bowen's disease and erythroplasia of Queyrat have been demonstrated to lead to the development of invasive squamous cell carcinoma. In contrast, bowenoid papulosis has a completely benign course with no present evidence suggesting the potential for malignant degeneration. The standard treatment for all 3 lesions in surgical excision, although use of the carbon dioxide or neodymium:YAG laser appears to be effective at obtaining local control of disease while achieving an excellent cosmetic result. Alternative treatments with micrographic surgery, topical 5-fluorouracil or radiotherapy have a more limited role. It is important to remember that adequate biopsies are always necessary to ensure a complete and accurate diagnosis, and allow for proper treatment and followup, as well as appropriate counseling of sexual partners.
Topics: Bowen's Disease; Carcinoma in Situ; Diagnosis, Differential; Erythroplasia; Humans; Male; Penile Neoplasms; Penis; Skin Neoplasms
PubMed: 8126803
DOI: 10.1016/s0022-5347(17)35099-1 -
European Urology Oncology Oct 2021
Topics: Carcinoma, Squamous Cell; Humans; Male; Papillomavirus Infections; Penile Neoplasms; Penis
PubMed: 33358392
DOI: 10.1016/j.euo.2020.12.005 -
Urology Sep 2017
Review
Topics: Carcinoma, Transitional Cell; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Nephrectomy; Penile Neoplasms; Penis; Urinary Bladder Neoplasms
PubMed: 28373110
DOI: 10.1016/j.urology.2017.03.036 -
Indian Journal of Cancer 2023Carcinoma penis is more common in India compared to the West. The role of chemotherapy in carcinoma penis is ambiguous. We analyzed the profile and outcomes of patients...
BACKGROUND
Carcinoma penis is more common in India compared to the West. The role of chemotherapy in carcinoma penis is ambiguous. We analyzed the profile and outcomes of patients with carcinoma penis treated with chemotherapy.
METHODS
We analyzed the details of all patients with carcinoma penis treated at our institute between 2012 and 2015. We collected particulars regarding demography, clinical presentation, treatment details, toxicities, and outcomes of these patients. Event-free and overall (OS) survival were calculated from the time of diagnosis until documentation of disease relapse/progression or death for the patients with advanced carcinoma penis who were eligible for chemotherapy.
RESULTS
There were 171 patients with carcinoma penis treated at our institute during the study period including 54 (31.6%) patients with stage I, 49 (28.7%) patients with stage II, 24 (14.0%) patients with stage III, 25 (14.6%) patients with stage IV, and 19 (11.1%) patients with recurrent disease at presentation. The present study included 68 patients with advanced carcinoma penis (stages III and IV) who were eligible for chemotherapy, with a median age of 55 years (range: 27-79 years). Sixteen patients received paclitaxel and carboplatin (PC) and 26 patients cisplatin and 5-FluoroUracil (CF). Neoadjuvant chemotherapy (NACT) was given to four patients with stage III and nine patients with stage IV disease. Of the 13 patients given NACT, we observed a partial response in five (38.5%), stable disease in two (15.4%), and progressive disease in five (38.5%) evaluable patients. Six (46%) patients underwent surgery after NACT. Only 28/54 (52%) patients received adjuvant chemotherapy. After a median follow-up of 17.2 months, the 2-year OS rates were 95.8, 89, 62.7, 51.9, and 28.6% for stages I, II, III, IV, and recurrent disease, respectively. The 2-year OS of patients who were given chemotherapy versus those who were not given chemotherapy were 52.7 and 63.2%, respectively (P = 0.762).
CONCLUSIONS
We report the real-world outcomes of two chemotherapeutic regimens used in consecutive patients with advanced carcinoma penis. Both PC and CF seemed effective and safe. However, approximately half of patients with advanced carcinoma penis do not receive the planned/indicated chemotherapy. We need further prospective trials regarding the sequencing, protocols and indications of chemotherapy in this malignancy.
Topics: Male; Humans; Adult; Middle Aged; Aged; Neoplasm Staging; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Carboplatin; Carcinoma; Chemotherapy, Adjuvant; Paclitaxel; Neoadjuvant Therapy; Penis
PubMed: 36861700
DOI: 10.4103/ijc.IJC_266_20 -
Quarterly Medical Review Apr 1986
Topics: Carcinoma, Squamous Cell; Humans; Male; Penile Neoplasms; Penis; Skin Neoplasms
PubMed: 3588832
DOI: No ID Found -
Medicina (Kaunas, Lithuania) Mar 2024Metastasis to the penis from renal cell carcinoma (RCC) or any other primary cancer site is unusual; when it does occur, it often involves multiple organs. A 75-year-old... (Review)
Review
Metastasis to the penis from renal cell carcinoma (RCC) or any other primary cancer site is unusual; when it does occur, it often involves multiple organs. A 75-year-old man presented with penile pain and swelling. Three months earlier, he had open radical nephrectomy with thrombectomy and was diagnosed with clear-cell RCC with tumor thrombosis in the inferior vena cava. The follow-up imaging indicated metastasis to the penis, prompting a total penectomy due to worsening pain. The excised mass displayed features consistent with metastatic RCC. This case underscores the need to consider rare metastatic sites, such as the metastasis of RCC to the penis, in RCC patients.
Topics: Humans; Male; Carcinoma, Renal Cell; Aged; Penile Neoplasms; Kidney Neoplasms; Nephrectomy; Neoplasm Metastasis; Penis
PubMed: 38674200
DOI: 10.3390/medicina60040554 -
The Urologic Clinics of North America Nov 1994Given the excellent local control rates achieved with partial penectomy, it is important to consider laser treatment or radiation therapy of squamous cell carcinoma of... (Review)
Review
Given the excellent local control rates achieved with partial penectomy, it is important to consider laser treatment or radiation therapy of squamous cell carcinoma of the penis cautiously. Emotional issues surrounding preservation of a functional penis should not be allowed to compromise adequate therapy. On the other hand, some penile cancers undoubtedly can be managed adequately by techniques other than partial penectomy. The fundamental question is, then, how great a compromise laser treatment or radiation therapy introduces. In patients who present with bulky, long-neglected penile cancers, the point is moot: Partial or even total penectomy is indicated. However, other treatments are feasible in many patients, and an attempt at functional organ preservation should not be restricted simply to the rare small tumor. Lesions up to 2 cm in size can be controlled adequately without amputation. Because tumor grade correlates highly with depth of invasion, the presence of nodal metastasis, and survival, most poorly differentiated squamous cell tumors of the penis probably should be treated by amputation. As mentioned above, it may be several months after laser treatment or radiation therapy before local treatment failure is recognized. Although this is a concern, it probably does not ultimately result in therapeutic compromise in most patients. With most urologic cancers, local recurrence equates with the inability to cure the patient and, ultimately, death. With locally recurrent carcinoma of the penis, however, the situation can be salvaged by converting to partial penectomy. Thus, the patient compromises his chances for cure only if tumor dissemination occurs during the few months between the end of treatment and recognition of failure.
Topics: Brachytherapy; Carcinoma, Squamous Cell; Erythroplasia; Humans; Laser Therapy; Male; Neoplasm Recurrence, Local; Penile Neoplasms; Penis; Radiotherapy, High-Energy
PubMed: 7974902
DOI: No ID Found -
The Journal of Urology Oct 1978
Review
Topics: Adult; Aged; Carcinoma, Squamous Cell; Humans; Inguinal Canal; Lymph Node Excision; Lymphatic Metastasis; Male; Methods; Middle Aged; Penile Neoplasms; Penis; Prognosis
PubMed: 359833
DOI: 10.1016/s0022-5347(17)57197-9 -
The Journal of Urology May 1952
Topics: Carcinoma; Humans; Male; Penile Neoplasms; Penis
PubMed: 14939386
DOI: 10.1016/S0022-5347(17)68409-X -
Cancer 1955
Topics: Carcinoma; Humans; Male; Penile Neoplasms; Penis
PubMed: 14352176
DOI: 10.1002/1097-0142(1955)8:2<371::aid-cncr2820080216>3.0.co;2-#