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Der Pathologe Nov 2017Malignant mesotheliomas are rare and aggressive tumours arising from mesothelial cells of the pleura and peritoneum. Infrequent sites of origin are the pericardium and...
Malignant mesotheliomas are rare and aggressive tumours arising from mesothelial cells of the pleura and peritoneum. Infrequent sites of origin are the pericardium and tunica vaginalis testis. More than 80% of mesotheliomas are localized in the pleura. Men are more frequently affected than women. The median age is >60 years. Asbestos exposure is the best known aetilogical risk factor and is reported in 54-90% of patients. In Germany, malignant mesotheliomas caused by occupational asbestos exposure are compensated as occupational disease since 1977. Several neoplastic and non-neoplastic lesions like metastasis, sarcomas, lymphomas or pleuritis with reactive mesothelial proliferation have to be distinguished from malignant mesotheliomas. Especially, the pathohistological differentiation between atypical reactive mesothelial proliferation from malignant mesothelioma is a diagnostic challenge.
Topics: Asbestos; Female; Germany; Humans; Lung Neoplasms; Male; Mesothelioma; Middle Aged; Risk Factors
PubMed: 28986649
DOI: 10.1007/s00292-017-0364-z -
The Pan African Medical Journal 2020Metastases to the heart and pericardium are much more common than primary malignant neoplasms. Primary malignant pericardial mesothelioma is a rare tumor that arises...
Metastases to the heart and pericardium are much more common than primary malignant neoplasms. Primary malignant pericardial mesothelioma is a rare tumor that arises from the mesothelial cells of the pericardium. It is usually characterized by a delayed diagnosis, a low response to treatment, and a poor prognosis with an overall survival up to six months after the onset of symptoms. We report a rare case of a 32-year-old woman with primary pericardial malignant mesothelioma that was diagnosed 4 months after the onset of pericardial effusion as the first clinical manifestation.
Topics: Adult; Delayed Diagnosis; Diagnosis, Differential; Female; Heart Neoplasms; Humans; Mesothelioma, Malignant; Pericardial Effusion; Pericarditis; Pericardium; Radiography, Thoracic; Tachycardia
PubMed: 33235652
DOI: 10.11604/pamj.2020.36.375.25336 -
Tumori 2005Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac... (Review)
Review
Malignant pericardial mesothelioma is an uncommon variety of a primary malignant cardio-pericardial tumor and it is a highly lethal and fortunately rare cardiac neoplasm. The presentation of pericardial mesothelioma is aspecific and pathologically mesothelioma is not the most common among primary tumors of the pericardium. It is characterized by atypical solid growth of mesothelium with formation of atypical cavities surrounded by fibrous stroma. Antemortem diagnosis is difficult and distant metastases are extremely rare. Radical surgery can be used to treat localized mesothelioma. The treatment for advanced primary pericardial mesothelioma is usually palliative because the tumor is resistant to radiotherapy and chemotherapy. The prognosis is unfavorable. The median survival from the onset of symptoms is six months. In this paper we report two cases of patients with primary mesothelioma of the pericardium without a definite history of asbestos exposure.
Topics: Adult; Aged; Diagnosis, Differential; Heart Neoplasms; Humans; Male; Mesothelioma; Pericardium; Prognosis; Survival
PubMed: 16206657
DOI: 10.1177/030089160509100315 -
European Journal of Cardio-thoracic... Mar 2011
Topics: Aged; Biopsy; Female; Heart Neoplasms; Humans; Mesothelioma; Pericardium; Positron-Emission Tomography; Tomography, X-Ray Computed
PubMed: 20643560
DOI: 10.1016/j.ejcts.2010.06.010 -
Cardiology Clinics Nov 2017Pericardial tumors are rare lesions that include a range of neoplastic conditions that may arise within the pericardium or metastasize to involve it secondarily.... (Review)
Review
Pericardial tumors are rare lesions that include a range of neoplastic conditions that may arise within the pericardium or metastasize to involve it secondarily. Understanding the spectrum of lesions that are included in the differential diagnosis of a pericardial mass-lesion is critical to making timely, accurate diagnoses and getting the appropriate therapy should one be necessary. This review summarizes the radiologic and pathologic findings of the most commonly encountered of these entities.
Topics: Autoimmune Diseases; Breast Neoplasms; Carcinoma; Echocardiography; Erdheim-Chester Disease; Heart Neoplasms; Hemangioma; Hemangiosarcoma; Humans; Immunoglobulin G; Lipoma; Lung Neoplasms; Lymphoma; Magnetic Resonance Imaging; Mediastinal Cyst; Mesothelioma; Mesothelioma, Malignant; Neoplasms, Germ Cell and Embryonal; Paraganglioma; Pericardium; Radiography, Thoracic; Sarcoma; Sarcoma, Synovial; Tomography, X-Ray Computed
PubMed: 29025549
DOI: 10.1016/j.ccl.2017.07.011 -
Veterinary Pathology May 1992
Topics: Animals; Dog Diseases; Dogs; Heart Neoplasms; Immunohistochemistry; Keratins; Male; Mesothelioma; Microscopy, Electron; Pericardium; Vimentin
PubMed: 1377849
DOI: 10.1177/030098589202900312 -
Kyobu Geka. the Japanese Journal of... Nov 2022A 67-year-old woman was referred to our hospital for cough and fever. Chest computed tomography (CT) showed some masses showing slightly enhanced effect in the...
A 67-year-old woman was referred to our hospital for cough and fever. Chest computed tomography (CT) showed some masses showing slightly enhanced effect in the pericardium. FDG-PET showed the accumulation of FDG in the masses. Thoracoscopic surgical biopsy was performed to establish the diagnosis. The histological study showed proliferation of short spindle-shaped cells surrounded by lymphocyte, and the spindle cells were immunohistochemically positive for cytokeratin AE1/AE3, WT-1, D2-40, CAM5.2, intelectin-1 and negative for CEA, TTF-1, napsin A, claudin-4, calretinin, MUC4, PAX8, CD30. These findings were compatible with epithelial pericardial malignant mesothelioma.
Topics: Female; Humans; Aged; Mesothelioma, Malignant; Mesothelioma; Calbindin 2; Fluorodeoxyglucose F18; Lung Neoplasms; Claudin-4; Heart Neoplasms; Mediastinal Neoplasms; Thymus Neoplasms; Keratins
PubMed: 36299163
DOI: No ID Found -
Annals of Epidemiology May 2017Malignant mesothelioma most commonly arises in the pleura and peritoneum but also occurs rarely at other anatomical sites with mesothelial tissue, namely, the... (Review)
Review
PURPOSE
Malignant mesothelioma most commonly arises in the pleura and peritoneum but also occurs rarely at other anatomical sites with mesothelial tissue, namely, the pericardium and tunica vaginalis testis (TVT). This review provides a better understanding of the epidemiology of mesothelioma of these extrapleural sites.
METHODS
We conducted a systematic review of the epidemiologic and clinical literature on pericardial mesothelioma and mesothelioma of the TVT. We also analyzed U.S. Surveillance, Epidemiology, and End Results cancer registry data to describe incidence patterns of these malignancies.
RESULTS
An etiologic role of asbestos exposure has been hypothesized for pericardial and TVT mesotheliomas, but no analytical case-control epidemiologic studies exist to test this relationship. A substantial proportion of cases with these malignancies report no known asbestos exposure. In large occupational cohorts with heavy asbestos exposures, no cases of pericardial or TVT mesothelioma have been reported. Trends in the incidence of these malignancies do not match those of pleural mesothelioma, which correspond to historical trends of commercial asbestos use. A male preponderance of pericardial mesothelioma is not evident.
CONCLUSIONS
In the absence of analytic epidemiologic studies, the etiologic role of environmental risk factors for mesothelioma of the pericardium and TVT remains elusive.
Topics: Asbestos; Female; Heart Neoplasms; Humans; Male; Mesothelioma; Middle Aged; Occupational Diseases; Pericardium; Registries; Testicular Neoplasms; Testis; United States
PubMed: 28527639
DOI: 10.1016/j.annepidem.2017.04.001 -
Texas Heart Institute Journal 2012A 72-year-old woman, on warfarin therapy and with a remote history of breast cancer and radiation treatment, presented with a 10-day history of nausea, dyspnea, dry... (Review)
Review
A 72-year-old woman, on warfarin therapy and with a remote history of breast cancer and radiation treatment, presented with a 10-day history of nausea, dyspnea, dry cough, and dizziness. An electrocardiogram showed new-onset atrial fibrillation. Computed tomography of the chest revealed multiple pulmonary emboli and a pericardial effusion. Echocardiography showed a pericardial effusion with tamponade characteristics. The patient's condition deteriorated, and a pericardiectomy was performed. Histologic evaluation confirmed primary pericardial mesothelioma. She underwent palliative treatment and died 3 months after discharge from the hospital. We discuss the patient's case and the nature of primary pericardial mesothelioma, a rare oncologic entity.
Topics: Aged; Biomarkers, Tumor; Biopsy; Cardiac Tamponade; Echocardiography, Doppler, Pulsed; Fatal Outcome; Female; Heart Neoplasms; Humans; Immunohistochemistry; Mesothelioma; Neoplasms, Second Primary; Palliative Care; Pericardial Effusion; Pericardiectomy; Pericardium; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 22740748
DOI: No ID Found -
American Heart Journal Feb 1955
Topics: Heart Neoplasms; Humans; Lymph Nodes; Mesothelioma; Neoplasms; Pericardium
PubMed: 13228366
DOI: 10.1016/0002-8703(55)90206-4