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Circulation. Cardiovascular Imaging Dec 2019
Topics: Adult; Cardiac Imaging Techniques; Colitis, Ulcerative; Echocardiography; Fatal Outcome; Heart Neoplasms; Humans; Magnetic Resonance Imaging; Male; Mesothelioma; Pericardial Effusion; Pericardiectomy; Pericardium; Positron-Emission Tomography; Predictive Value of Tests; Treatment Outcome
PubMed: 30632392
DOI: 10.1161/CIRCIMAGING.118.008659 -
Lung Cancer (Amsterdam, Netherlands) May 2008Primary pericardial mesothelioma is a rare clinical entity; about 150 cases have been described in literature. It is a highly aggressive tumour with global survival...
Primary pericardial mesothelioma is a rare clinical entity; about 150 cases have been described in literature. It is a highly aggressive tumour with global survival under 6 months. We present a 44-year-old man with a primary pericardial mesothelioma who received treatment under clinical essay with carboplatinum and pemetrexed reaching tumoral response; consolidation radiotherapy was administered. Ten months after end of radiotherapy, tumoral progression was detected, and patient received second line of chemotherapy. The patient died 16 months after diagnosis. New cytotoxic drugs can improve the prognosis of this rare entity.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined Modality Therapy; Fatal Outcome; Glutamates; Guanine; Heart Neoplasms; Humans; Male; Mesothelioma; Pemetrexed; Pericardium; Radiotherapy
PubMed: 17936406
DOI: 10.1016/j.lungcan.2007.08.029 -
The International Journal of... Jul 2020
Topics: Aged; Biopsy; Echocardiography, Doppler; Heart Neoplasms; Humans; Lung Neoplasms; Male; Mesothelioma; Mesothelioma, Malignant; Multimodal Imaging; Pericardiectomy; Pericardium; Positron-Emission Tomography; Predictive Value of Tests; Tomography, X-Ray Computed
PubMed: 32253564
DOI: 10.1007/s10554-020-01829-1 -
Cardiovascular Pathology : the Official... 2001Primary pericardial mesothelioma is an extremely rare tumor. This case illustrates the typical late presentation of primary pericardial mesothelioma with symptoms and...
Primary pericardial mesothelioma is an extremely rare tumor. This case illustrates the typical late presentation of primary pericardial mesothelioma with symptoms and signs of constrictive pericarditis. An unusual feature was the complete encasement of the heart by the tumor. No satisfactory treatment was available.
Topics: Adult; Fatal Outcome; Heart Neoplasms; Humans; Male; Mesothelioma; Myocardium; Pericardial Effusion; Pericarditis; Pericardium
PubMed: 11485860
DOI: 10.1016/s1054-8807(01)00073-4 -
Revista Portuguesa de Cardiologia :... Apr 2017Primary cardiac and pericardial tumors are rare entities with an autopsy frequency of 0.001-0.03%. Metastases to the heart and pericardium are much more common than...
Primary cardiac and pericardial tumors are rare entities with an autopsy frequency of 0.001-0.03%. Metastases to the heart and pericardium are much more common than primary tumors. Malignant pericardial mesotheliomas account for up to 50% of primary pericardial tumors. We report the case of a 75-year-old woman with hypertension, dyslipidemia and atrial fibrillation who went to the emergency department due to nonspecific thoracic discomfort of over six hours duration associated with syncope. Physical examination revealed a low-amplitude arrhythmic pulse, no heart murmurs and no signs of pulmonary congestion. The ECG revealed atrial fibrillation with ST-segment elevation in V2-V6, I and aVL. The patient was transferred for emergent coronary angiography, which revealed a long stenosis in the mid-distal portion of the left anterior descending artery. The echocardiogram showed a large pericardial effusion with diffuse thickening of the myocardium. Due to worsening hemodynamics, cardiac rupture was suspected and the patient underwent urgent sternotomy and pericardiotomy with drainage of a large quantity of hematic fluid. The surgeons then identified a large, unresectable tumor occupying the distal half of the anterior portion of the heart. This is, to our knowledge, the first case report of primary pericardial mesothelioma presenting with suspected ST-elevation myocardial infarction. In this case, direct observation of the tumor led to biopsy and the final diagnosis. These are highly malignant tumors and when diagnosed are usually already at an advanced stage.
Topics: Aged; Female; Heart Neoplasms; Humans; Mesothelioma; Pericardium; ST Elevation Myocardial Infarction
PubMed: 28343785
DOI: 10.1016/j.repc.2016.03.014 -
Annales Medicinae Internae Fenniae 1963
Topics: Cardiac Surgical Procedures; Heart Neoplasms; Humans; Mesothelioma; Pericardium; Pleural Neoplasms; Radiography, Thoracic; Thoracic Surgery
PubMed: 14080535
DOI: No ID Found -
Journal of Zoo and Wildlife Medicine :... Jan 2021A 1.5 kg, male, wild-caught tiger rat snake () presented with an externally visible distension of the body wall at the level of the heart. Ultrasound examination showed...
A 1.5 kg, male, wild-caught tiger rat snake () presented with an externally visible distension of the body wall at the level of the heart. Ultrasound examination showed marked pericardial effusion. Pericardial fluid showed no bacterial or fungal growth, few leukocytes, and few suspected reactive mesothelial or neoplastic cells. Therapeutic pericardiocentesis was successfully performed, removing most of the fluid from the pericardial sac. The snake had mild lethargy and weakness immediately after the procedure but returned to normal behavior within 2 wk. Repeat pericardiocentesis was performed 6 mo after the initial presentation when moderate refilling of the pericardial sac was seen. The snake died 4 days after the second procedure with acute hemorrhage. Pericardial mesothelioma was diagnosed by histopathology after postmortem examination. This report provides the first documented case of mesothelioma in a tiger rat snake and the first description of the disease in colubrids.
Topics: Animals; Colubridae; Fatal Outcome; Heart Neoplasms; Male; Mesothelioma; Pericardial Effusion; Pericardiocentesis; Pericardium
PubMed: 33480594
DOI: 10.1638/2019-0190 -
Orphanet Journal of Rare Diseases Dec 2008Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the... (Review)
Review
Malignant mesothelioma is a fatal asbestos-associated malignancy originating from the lining cells (mesothelium) of the pleural and peritoneal cavities, as well as the pericardium and the tunica vaginalis. The exact prevalence is unknown but it is estimated that mesotheliomas represent less than 1% of all cancers. Its incidence is increasing, with an expected peak in the next 10-20 years. Pleural malignant mesothelioma is the most common form of mesothelioma. Typical presenting features are those of chest pain and dyspnoea. Breathlessness due to a pleural effusion without chest pain is reported in about 30% of patients. A chest wall mass, weight loss, sweating, abdominal pain and ascites (due to peritoneal involvement) are less common presentations. Mesothelioma is directly attributable to occupational asbestos exposure with a history of exposure in over 90% of cases. There is also evidence that mesothelioma may result from both para-occupational exposure and non-occupational "environmental" exposure. Idiopathic or spontaneous mesothelioma can also occur in the absence of any exposure to asbestos, with a spontaneous rate in humans of around one per million. A combination of accurate exposure history, along with examination radiology and pathology are essential to make the diagnosis. Distinguishing malignant from benign pleural disease can be challenging. The most helpful CT findings suggesting malignant pleural disease are 1) a circumferential pleural rind, 2) nodular pleural thickening, 3) pleural thickening of > 1 cm and 4) mediastinal pleural involvement. Involvement of a multidisciplinary team is recommended to ensure prompt and appropriate management, using a framework of radiotherapy, chemotherapy, surgery and symptom palliation with end of life care. Compensation issues must also be considered. Life expectancy in malignant mesothelioma is poor, with a median survival of about one year following diagnosis.
Topics: Humans; Mesothelioma; Pleural Neoplasms; Tomography, X-Ray Computed
PubMed: 19099560
DOI: 10.1186/1750-1172-3-34 -
Cardiovascular Pathology : the Official... 2010We report a case of a malignant pericardial mesothelioma of the epithelioid type in a 39-year-old man. He had a history of nodular sclerosing Hodgkin's disease treated... (Review)
Review
We report a case of a malignant pericardial mesothelioma of the epithelioid type in a 39-year-old man. He had a history of nodular sclerosing Hodgkin's disease treated with irradiation of the cervical and mediastinal regions 24 years before, and of infarction of the anterior wall of the left ventricle, after which a percutaneous coronary intervention was carried out 7 years previously. He was admitted to a cardiology unit with progressive dyspnea. On examination, a hemorrhagic pericardial fluid collection of 600 ml was detected which was successfully drained. On the next day, the patient developed an electromechanical dissociation suggesting a pericardial tamponade, which was followed by circulatory arrest. At autopsy, the pericardial sac was found to contain 300 ml of partly clotted blood. The epicardial surface showed a diffuse thickening, suggesting a chronic fibrous pericarditis without a macroscopically evident distinct tumor mass. A rupture measuring 0.4 cm in diameter was detected in the right ventricular free wall, 1 cm below the level of the tricuspid valve. The diagnosis of a diffusely growing, malignant mesothelioma of the epithelioid type was made on the basis of histological and immunohistochemical examination of the thickened pericardium.
Topics: Adult; Autopsy; Cardiac Tamponade; Fatal Outcome; Heart Neoplasms; Hodgkin Disease; Humans; Immunohistochemistry; Male; Mesothelioma; Neoplasms, Radiation-Induced; Pericardial Effusion; Pericardium; Radiotherapy; Shock
PubMed: 19914093
DOI: 10.1016/j.carpath.2009.08.003 -
Acta Chirurgica Belgica Feb 2022Pericardial malignant mesothelioma (MM) is a rare tumour which accounts for about 1% of all mesotheliomas, 4% of the primary heart and pericardial tumours. It carries an...
Pericardial malignant mesothelioma (MM) is a rare tumour which accounts for about 1% of all mesotheliomas, 4% of the primary heart and pericardial tumours. It carries an extremely poor prognosis, with a reported overall survival of less than 6 months. Clinical symptoms and signs are frequently nonspecific, and the diagnosis is usually made after surgery or at autopsy. We report a case of a 72 years old woman with primary pericardial malignant mesothelioma involving the right atrium. Nine months following surgery, the patient is alive with good performance status.
Topics: Aged; Female; Heart Neoplasms; Humans; Mesothelioma; Mesothelioma, Malignant; Pericardium; Pleural Neoplasms
PubMed: 32106775
DOI: 10.1080/00015458.2020.1736869