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Skin Research and Technology : Official... Jul 2023The decline in estrogen levels from several years before (perimenopause) and during menopause has various negative effects, including skin specific issues, which often... (Observational Study)
Observational Study
Evaluation of adapted dermocosmetic regimens for perimenopausal and menopausal women using an artificial intelligence-based algorithm and quality of life questionnaires: An open observational study.
BACKGROUND
The decline in estrogen levels from several years before (perimenopause) and during menopause has various negative effects, including skin specific issues, which often receive less attention than other menopausal symptoms despite having a significant negative effect on quality of life (QoL). The objective of this study was to evaluate the effectiveness of anti-aging dermocosmetic products designed for women during the perimenopause and menopause.
MATERIALS AND METHODS
An open study of 101 perimenopausal women (no menstruation for 4-12 months or irregular menstruation for <5 years) and 101 menopausal women (no menstruation for >12 months), not taking hormone replacement therapy, was conducted. Adapted dermocosmetic regimens, specific to each group (day cream, night cream and serum), were applied for 56 days. Assessments included automatic artificial intelligence diagnostics of eight clinical facial signs, hydration and transepidermal water loss (TEWL), and a menopause skin QoL questionnaire.
RESULTS
Mean age was 50 ± 3.9 years (range 41-57) and 59 ± 3.8 years (range 50-66) for the perimenopause and menopause groups, respectively. Significant improvements in wrinkles and vascular signs, increases in hydration, decreases in TEWL, and a positive impact on QoL were observed after 56 days of application of the respective dermocosmetic regimens for both the perimenopause and menopause groups.
CONCLUSION
The anti-aging skin care products designed specifically for perimenopausal and menopausal women increased skin hydration and improved wrinkles with a positive impact on QoL.
Topics: Female; Humans; Adult; Middle Aged; Perimenopause; Quality of Life; Artificial Intelligence; Menopause; Surveys and Questionnaires; Algorithms
PubMed: 37522490
DOI: 10.1111/srt.13349 -
Maturitas Aug 2014Perimenopause and migraine are closely linked. The hormonal instability during the perimenopausal period not only causes vasomotor symptoms and mood disturbances, but... (Review)
Review
Perimenopause and migraine are closely linked. The hormonal instability during the perimenopausal period not only causes vasomotor symptoms and mood disturbances, but also increases migraine incidence. Women do report new onset migraine during this period, but the increased incidence is reported by women with menstrually related migraine (MRM). The hormonal fluctuations can be stabilized with hormone replacement therapy (HRT), while simultaneously improving the migraine in some patients. The increased stroke risk in women with migraine with aura (MA) should be taken into consideration when intending to treat perimenopausal women with migraine with HRT.
Topics: Estrogen Replacement Therapy; Hormones; Humans; Menstruation; Migraine Disorders; Perimenopause; Stroke
PubMed: 24954701
DOI: 10.1016/j.maturitas.2014.05.018 -
Brain Research Mar 2011Evidence suggests that initiation of some forms of hormone therapy (HT) early in the perimenopausal or postmenopausal stage might confer benefit to verbal memory and the... (Comparative Study)
Comparative Study Randomized Controlled Trial
Evidence suggests that initiation of some forms of hormone therapy (HT) early in the perimenopausal or postmenopausal stage might confer benefit to verbal memory and the neural systems underlying memory, whereas late-life initiation confers no benefit or harm. This "critical window hypothesis" remains a topic of debate. Using functional magnetic resonance imaging (fMRI), we examined the long-term impact of perimenopausal HT use on brain function during performance of verbal and figural memory tasks. Participants were 34 postmenopausal women (mean age 60 years) from the Melbourne Women's Midlife Health Project and included 17 early (perimenopausal) and continuous users of HT and 17 never users matched on age, education, and verbal knowledge. Continuous HT use from the perimenopausal stage versus no use was validated with prospective daily diary records and study visit data. The primary outcome was patterns of brain activation in an a priori region of interest in the medial temporal lobe during verbal encoding and recognition of words. Results indicated that perimenopausal HT users performed better than nonusers on the imaging verbal memory task (p<.05). During verbal recognition, perimenopausal HT users showed increased activation in the left hippocampus and decreased activation in the parahippocampal gyrus bilaterally compared with never users. Each of these patterns of activation was associated with better memory performance on the imaging memory task. These results suggest that perimenopausal use of HT might confer long-term benefits to verbal memory and the brain systems underlying verbal memory. More generally, the results support the critical window hypothesis.
Topics: Age Factors; Aged; Estrogen Replacement Therapy; Female; Follow-Up Studies; Hippocampus; Hormone Replacement Therapy; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Memory; Middle Aged; Perimenopause; Prospective Studies
PubMed: 21078303
DOI: 10.1016/j.brainres.2010.11.030 -
Maturitas Jun 2011
Topics: Autonomic Nerve Block; Female; Hot Flashes; Humans; Perimenopause; Stellate Ganglion
PubMed: 21377301
DOI: 10.1016/j.maturitas.2011.02.008 -
JAMA Internal Medicine Aug 2023Due to the potential risks of long-term systemic estrogen therapy, many menopausal women are interested in nonhormonal treatments for vasomotor symptoms. Physiologic... (Randomized Controlled Trial)
Randomized Controlled Trial
Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial.
IMPORTANCE
Due to the potential risks of long-term systemic estrogen therapy, many menopausal women are interested in nonhormonal treatments for vasomotor symptoms. Physiologic studies indicate that nitric oxide plays a key role in mediating hot flash-related vasodilation, suggesting that nonhormonal medications that induce nitrate tolerance in the vasculature may offer therapeutic benefit for vasomotor symptoms.
OBJECTIVE
To determine whether uninterrupted administration of transdermal nitroglycerin (NTG) to induce nitrate cross-tolerance decreased the frequency or severity of menopause-related hot flashes.
DESIGN, SETTING, AND PARTICIPANTS
This randomized, double-blinded, placebo-controlled clinical trial included perimenopausal or postmenopausal women reporting 7 or more hot flashes per day who were recruited from northern California by study personnel at a single academic center. Patients were randomized between July 2017 and December 2021, and the trial ended in April 2022 when the last randomized participant completed follow-up.
INTERVENTIONS
Uninterrupted daily use of transdermal NTG (participant-directed dose titration from 0.2-0.6 mg/h) or identical placebo patches.
MAIN OUTCOME MEASURES
Validated symptom diaries assessing changes in any hot flash frequency (primary outcome) and moderate-to-severe hot flash frequency over 5 and 12 weeks.
RESULTS
Among the 141 randomized participants (70 NTG [49.6%], 71 placebo [50.4%]; 12 [85.8%] Asian, 16 [11.3%] Black or African American, 15 [10.6%] Hispanic or Latina, 3 [2.1%] multiracial, 1 [0.7%] Native Hawaiian or Pacific Islander, and 100 [70.9%] White or Caucasian individuals), a mean (SD) of 10.8 (3.5) hot flashes and 8.4 (3.6) moderate-to-severe hot flashes daily was reported at baseline. Sixty-five participants assigned to NTG (92.9%) and 69 assigned to placebo (97.2%) completed 12-week follow-up (P = .27). Over 5 weeks, the estimated change in any hot flash frequency associated with NTG vs placebo was -0.9 (95% CI, -2.1 to 0.3) episodes per day (P = .10), and change in moderate-to-severe hot flash frequency with NTG vs placebo was -1.1 (95% CI, -2.2 to 0) episodes per day (P = .05). At 12 weeks, treatment with NTG did not significantly decrease the frequency of any hot flashes (-0.1 episodes per day; 95% CI, -1.2 to 0.4) or moderate-to-severe hot flashes (-0.5 episodes per day; 95% CI, -1.6 to 0.7) relative to placebo. In analyses combining 5-week and 12-week data, no significant differences in change in the frequency of any hot flashes (-0.5 episodes per day; 95% CI, -1.6 to 0.6; P = .25) or moderate-to-severe hot flashes (-0.8 episodes per day; 95% CI, -1.9 to 0.2; P = .12) were detected with NTG vs placebo. At 1 week, 47 NTG (67.1%) and 4 placebo participants (5.6%) reported headache (P < .001), but only 1 participant in each group reported headache at 12 weeks.
CONCLUSIONS AND RELEVANCE
This randomized clinical trial found that continuous use of NTG did not result in sustained improvements in hot flash frequency or severity relative to placebo and was associated with more early but not persistent headache.
TRIAL REGISTRATION
Clinicaltrials.gov Identifier: NCT02714205.
Topics: Humans; Female; Hot Flashes; Nitroglycerin; Postmenopause; Nitrates; Perimenopause; Menopause; Double-Blind Method; Treatment Outcome
PubMed: 37273224
DOI: 10.1001/jamainternmed.2023.1977 -
Wiadomosci Lekarskie (Warsaw, Poland :... 2022The aim: To examine the effect of the developed wellness program on hemodynamic indices and psychological state of perimenopausal women.
OBJECTIVE
The aim: To examine the effect of the developed wellness program on hemodynamic indices and psychological state of perimenopausal women.
PATIENTS AND METHODS
Materials and methods: The study involved 27 women aged 39 to 47 years. Inclusion criteria: recorded perimenopause, climacteric syndrome, history of episodic increase in blood pressure up to 140/85 or 150/90 mmHg. Exclusion criteria: primary hypertension, diabetes mellitus, chronic contagious, systemic, oncology diseases, and mental illnesses. Research procedure comprised tracing of the heart rate, blood pressure registration, and pulse pressure calculation. Robinson index, the coefficient of endurance according to A. Kvas formula were calculated. The assessment of psychological state was made using the Spielberger-Khanin Inventory.
RESULTS
Results: Multidisciplinary professionals gave classes upon wellness program at "Women's Health" school. The program included educational conversations, healthy walking, massage, psycho-corrective exercises. The dynamics of the studied parameters was analyzed after 12 weeks. Based on the anthropometric measures findings the tested women showed improvement of 6,76% weight loss; and their body mass index decreased by 6,77%. Initial numbers of Robinson index and the coefficient of endurance were above normal values. After working under the program statistically significant dynamics was observed (р <0,05), although there were still signs of cardiovascular disorders. There were statistically significant positive changes Spielberger-Khanin Inventory on State Anxiety (-9,09%) and Personal Anxiety Scales (-6,96%) (p <0,05).
CONCLUSION
Conclusions: Early detection of risk factors and physical activity will help to bring a vast improvement to prognosis and quality of life of perimenopausal women with hypertension onset.
Topics: Adult; Blood Pressure; Exercise; Female; Humans; Hypertension; Middle Aged; Perimenopause; Quality of Life
PubMed: 35307684
DOI: No ID Found -
Archives of Gynecology and Obstetrics Apr 2020A high percentage of menopausal and perimenopausal women suffer symptoms that deteriorate their quality of life (QoL) significantly. Many studies have focused on the...
BACKGROUND
A high percentage of menopausal and perimenopausal women suffer symptoms that deteriorate their quality of life (QoL) significantly. Many studies have focused on the relationship between perimenopausal symptoms and QoL, yet the results obtained have been inconclusive. The aim of this study is to evaluate the relationships among the symptoms of menopause, sociodemographic variables, knowledge of menopause and QoL.
METHOD
Sociodemographic and clinical data was collected from interviews of 453 women in Madrid, and they also completed questionnaires related to perimenopausal symptomatology (MRS, MENQOL), knowledge of menopause and QoL.
RESULTS
Although dependent on the assessment techniques, all the tools used indicated that more than half of the women studied suffered perimenopausal symptomatology: interview (59.1%), MENQOL (69.2%) and MRS (65.1%). Stronger symptoms were related to a worse QoL (R = 0.287 for MENQOL; R = 0.390 for MRS), being psychosocial/psychological and urogenital/sexual symptomatology, and educational level and knowledge about menopause the most strongly related to this parameter. Taking into account the main perimenopausal symptoms in Europe, psychosocial and sexual symptoms are also found to be strongly related to QoL.
CONCLUSION
Perimenopausal symptomatology is frequent and intense, deteriorating women's QoL. While psychosocial and somatic/physical symptoms are the most frequent and intense, psychosocial/psychological and urogenital/sexual are those that best predict the individual's QoL. Educational level and knowledge about menopause are also related to a better QoL.
Topics: Cross-Sectional Studies; Female; Humans; Menopause; Middle Aged; Perimenopause; Quality of Life; Socioeconomic Factors; Stress, Psychological; Surveys and Questionnaires
PubMed: 31302734
DOI: 10.1007/s00404-019-05238-1 -
BMJ (Clinical Research Ed.) Jan 2024
Topics: Female; Humans; Perimenopause; Estrogen Replacement Therapy; Hormone Replacement Therapy; Antidepressive Agents
PubMed: 38286465
DOI: 10.1136/bmj.q220 -
Zhongguo Zhen Jiu = Chinese Acupuncture... Mar 2021Professor -'s experience of acupuncture for perimenopausal panic disorder was summarized. Professor believes that the etiology and pathogenesis of perimenopausal panic...
Professor -'s experience of acupuncture for perimenopausal panic disorder was summarized. Professor believes that the etiology and pathogenesis of perimenopausal panic disorder are the deficiency of congenital kidney essence and the injury of acquired spleen and stomach, leading to mental dysfunction. The clinical treatment should be based on the principle of "nourishing the congenital, tonifying the acquired, and regulating thoroughfare vessel and conception vessel". As for the acupoint selection, the combination of back- point and the front- point is valued; as for the acupuncture technique, quick needling and skillful application of catgut embedding are recommended. The combination of acupuncture and medicine shows synergistic effect. In addition, emotional therapy is also applied for this condition. In conclusion, it is advocated to treat perimenopausal panic disorder with the combination of acupuncture, catgut embedding, herbs and emotional therapy.
Topics: Acupuncture; Acupuncture Points; Acupuncture Therapy; Catgut; Humans; Panic Disorder; Perimenopause
PubMed: 33798317
DOI: 10.13703/j.0255-2930.20200120-k0003 -
Minerva Pediatrics Oct 2022
Topics: Humans; Female; Progestins; Perimenopause; Estrogens; Estrogen Replacement Therapy
PubMed: 35726767
DOI: 10.23736/S2724-5276.22.06899-9