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Journal (Canadian Dental Association) 1997The gingival cyst of the adult (GCA) is an uncommon gingival lesion that is usually found within attached or unattached soft tissues. It is generally considered to be a... (Review)
Review
The gingival cyst of the adult (GCA) is an uncommon gingival lesion that is usually found within attached or unattached soft tissues. It is generally considered to be a cyst of odontogenic origin, though this is still debated somewhat. This article reviews the diagnosis and treatment of GCA and summarizes the features of eight cases.
Topics: Adult; Aged; Diagnosis, Differential; Epithelium; Female; Follow-Up Studies; Gingival Diseases; Humans; Male; Middle Aged; Odontogenic Cysts; Periodontal Cyst
PubMed: 9264213
DOI: No ID Found -
Oral Surgery, Oral Medicine, Oral... Feb 2011Lateral periodontal cyst (LPC) is a developmental jaw cyst of odontogenic origin. It has characteristic histopathologic features that are identical to those seen in the... (Review)
Review
Lateral periodontal cyst (LPC) is a developmental jaw cyst of odontogenic origin. It has characteristic histopathologic features that are identical to those seen in the peripherally occurring gingival cyst of adults (GCA). The polycystic variant of LPC is termed the botryoid odontogenic cyst (BOC). The histogenetic origin of LPC is probably the rests of dental lamina in the alveolar bone. In the case of BOC, it might be that several adjacent epithelial rests simultaneously undergo cystic change and eventually form a polycystic lesion. Few previous examples of multifocal occurrence of LPC can be found in the literature. We report an additional 4 patients with this rare presentation of multiple, separate LPCs, and review the literature on this topic.
Topics: Adult; Female; Gingiva; Humans; Male; Mandibular Diseases; Middle Aged; Periodontal Cyst; Radiography; Treatment Outcome
PubMed: 21237438
DOI: 10.1016/j.tripleo.2010.09.072 -
Oral Surgery, Oral Medicine, and Oral... Feb 1967
Topics: Cuspid; Female; Humans; Incisor; Middle Aged; Periodontal Cyst
PubMed: 5225442
DOI: 10.1016/0030-4220(67)90093-x -
The British Journal of Oral &... Oct 1990Mandibular infected buccal cysts occur on the buccal and distal aspects of the roots of partly or fully erupted mandibular molars with vital pulps. In the present... (Review)
Review
Mandibular infected buccal cysts occur on the buccal and distal aspects of the roots of partly or fully erupted mandibular molars with vital pulps. In the present investigation six cases associated with mandibular first and second molars were studied. The cysts were lined with a non-keratinised squamous epithelium with a mixed inflammatory cell infiltrate in the connective tissue. The clinical and microscopic features were similar to those of previously reported paradental cysts. The inflammation always present in these cysts may have an important role in their pathogenesis. It may induce periodontal pocketing, which may lead to hyperplasia and cyst formation in adjacent odontogenic epithelium, which may be either remnants of the reduced enamel epithelium or cell rests of Malassez.
Topics: Adolescent; Child; Epithelium; Female; Follow-Up Studies; Humans; Inflammation; Male; Mandibular Diseases; Molar; Neutrophils; Periodontal Cyst; Radiography
PubMed: 2248940
DOI: 10.1016/0266-4356(90)90107-v -
Journal of Oral Pathology Jan 1985Numerous papers on epithelial jaw cysts have appeared in the decade since the publication in 1971 of the WHO histological classification of odontogenic tumours, jaw... (Review)
Review
Numerous papers on epithelial jaw cysts have appeared in the decade since the publication in 1971 of the WHO histological classification of odontogenic tumours, jaw cysts, and allied lesions. Despite clarification of certain cyst varieties no major revisions are necessary. The following minor modifications are proposed. In the developmental odontogenic group, the terms keratocyst and follicular are preferred to primordial and dentigerous. The alveolar cyst of infants is categorised separately from the gingival cyst of adults. The developmental lateral periodontal cyst is included as a distinctive new type. In the non-odontogenic group the globulomaxillary is deleted as a unique entity, whereas the midpalatal cyst of infants is a new inclusion. To the inflammatory category are added the inflammatory follicular and inflammatory lateral periodontal varieties.
Topics: Adult; Child; Cysts; Dentigerous Cyst; Gingival Diseases; Humans; Jaw Cysts; Nonodontogenic Cysts; Odontogenic Cysts; Periodontal Cyst; Radicular Cyst; World Health Organization
PubMed: 3918149
DOI: 10.1111/j.1600-0714.1985.tb00459.x -
Oral Surgery, Oral Medicine, and Oral... Jun 1950
Topics: Humans; Jaw; Mandible; Periodontal Cyst
PubMed: 15423870
DOI: 10.1016/0030-4220(50)90271-4 -
Biotechnic & Histochemistry : Official... 2017The botryoid odontogenic cyst (BOC) is a rare, locally more aggressive variant of the usually indolent lateral periodontal cyst (LPC) and gingival cyst (GC). A recent...
Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts.
The botryoid odontogenic cyst (BOC) is a rare, locally more aggressive variant of the usually indolent lateral periodontal cyst (LPC) and gingival cyst (GC). A recent case of BOC provided an opportunity for an exploratory study on the causes of its more aggressive behavior. The limited objective was to see if the BOC was sufficiently different from the other cysts to warrant an investment in a large study. Sections of neutral buffered formalin fixed, paraffin-embedded tissues from the BOC and archival specimens of four GCs, four LPCs and three odontogenic keratocysts (OKCs) were stained using immunohistochemistry for Ki-67, a marker of proliferating cells, caspase-3, a marker of cells undergoing apoptosis, tumor suppressor p53, and the apoptosis inhibitor BCL2. The mean labeling index (LI) of immunoreactive cyst epithelial cells was computed for each antibody and type of cyst. Compared to the LPCs and GCs, the BOC exhibited a moderately larger Ki-67/caspase-3 LI difference, which indicates that the BOC had a net higher rate of growth. We found a much higher level of LI, therefore likely dysregulation of p53. We also found a much higher LI of BCL2. The LIs of p53 and BCL2 in the BOC were similar to and more than twice that of the OKCs, respectively. Although meaningful statistical analysis was precluded by our use of only one case of BOC and a small number of the other cysts, the high p53 and very high BCL2 labeling indices of the BOC offer a potential explanation for its reportedly more aggressive behavior that clearly is worthy of further investigation.
Topics: Apoptosis; Cell Proliferation; Epithelium; Gingival Diseases; Humans; Immunohistochemistry; Odontogenic Cysts; Periodontal Cyst; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53
PubMed: 28910164
DOI: 10.1080/10520295.2017.1367231 -
Oral Diseases Oct 2008The present review analyzes the accumulated data from all cases of glandular odontogenic cyst (GOC) reported in the English language literature. In the 20 years since it... (Review)
Review
The present review analyzes the accumulated data from all cases of glandular odontogenic cyst (GOC) reported in the English language literature. In the 20 years since it was first described, 111 cases have been reported, an incidence of 0.2% of odontogenic cysts. The age range is 14-75, mean 45.7, with a M/F ratio of 1.3:1. GOC has a predilection for the mandible (70%), affecting both anterior and posterior areas. It is typically radiolucent, well defined, either unilocular (53.8%) or multilocular (46.2%). Frequent perforation (61%) and of thinning of cortical plates (24.4%) indicate aggressiveness. Sufficient follow-up indicates that 30% of cases can recur. Treatment by enucleation or curettage carries the highest risk for recurrence, especially in large and multilocular lesions. Peripheral osteoectomy or marginal resection can eliminate the risk. Defined criteria for microscopic diagnosis are described, which in addition to Ki67 and p53 can help in differentiating GOC from lesions with histological similarities (cysts with mucous metaplasia, botryoid and surgical ciliated cysts, low-grade mucoepidermoid carcinoma). Definite diagnosis may not be possible in small incisional biopsies due to the focal presentation of characteristic features required for diagnosis. There is now evidence to support an odontogenic rather than a sialogenic origin.
Topics: Diagnosis, Differential; Humans; Jaw Cysts; Odontogenic Cysts; Periodontal Cyst; Salivary Gland Diseases
PubMed: 18248589
DOI: 10.1111/j.1601-0825.2007.01428.x -
Minerva Stomatologica Jan 1990The clinical and histopathological features of two cases of botryoid odontogenic cyst are reported. The lesion is an uncommon variant of the lateral periodontal cyst and...
The clinical and histopathological features of two cases of botryoid odontogenic cyst are reported. The lesion is an uncommon variant of the lateral periodontal cyst and differs from this with regard to the histopathological features and the biological behaviour.
Topics: Aged; Female; Humans; Male; Mandibular Diseases; Middle Aged; Odontogenic Cysts; Periodontal Cyst; Radiography
PubMed: 2329979
DOI: No ID Found -
Oral Surgery, Oral Medicine, Oral... Feb 1997The clinical, radiographic, and histologic features of the mandibular buccal bifurcation cyst were studied to further define this lesion. The treatment and outcomes were... (Review)
Review
OBJECTIVE
The clinical, radiographic, and histologic features of the mandibular buccal bifurcation cyst were studied to further define this lesion. The treatment and outcomes were also analyzed.
STUDY DESIGN
This prospective study, which spanned 3 years, included 32 patients. Their ages ranged from 5.5 to 11 years (mean of 7.5). A total of 44 buccal bifurcation cysts were treated solely with enucleation, and patients were followed up for 2.5 to 3 years.
RESULTS
All lesions were located at the buccal bifurcation of the mandibular first molar. Tilting of the buccal cusps, causing prominence of the lingual cusps, occurred in 75% of the cases. The lesion extended from the buccal bifurcation to the tooth apex in 81.2%, and a periosteal reaction on the lateral surface of the mandible adjacent to the cyst was noted in 68.8% of the cases. All of the 44 histologic reports were nonspecific, but showed a cyst lining of stratified squamous epithelium with chronic inflammation. Microbiology consisted of mixed oral flora. Complete radiographic healing in all sites without recurrence was noted in 2.5-year follow-up. The periodontal pocket depth around all the involved teeth was normalized. No loss of the mandibular first molars occurred.
CONCLUSIONS
The mandibular buccal bifurcation cyst is a distinct site-specific and age-specific clinical entity treatable by enucleation without tooth extraction.
Topics: Age Factors; Cheek; Child; Child, Preschool; Female; Furcation Defects; Humans; Male; Mandibular Diseases; Molar; Periodontal Cyst; Periodontal Pocket; Prospective Studies; Tooth Eruption; Treatment Outcome
PubMed: 9117753
DOI: 10.1016/s1079-2104(97)90008-1