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Practical Neurology Apr 2011Long lists of causes of peripheral neuropathy make peripheral nerve disease a dry and uninspiring subject. A simple scheme based on the answers to just six questions... (Review)
Review
Long lists of causes of peripheral neuropathy make peripheral nerve disease a dry and uninspiring subject. A simple scheme based on the answers to just six questions should enable the clinician to recognise characteristic patterns, investigate relevant subgroups appropriately, and identify treatable disorders quickly: which systems are involved? What is the distribution of weakness? What is the nature of the sensory involvement? Is there any evidence of upper motor neuron involvement? What is the temporal evolution? Is there any evidence for a hereditary neuropathy? Standard screening investigations suffice for the common length dependent axonal neuropathies while complex presentations need more detailed investigations targeted to their clinical phenotype.
Topics: Diagnosis, Differential; Diagnostic Techniques, Neurological; Humans; Medical History Taking; Peripheral Nervous System Diseases
PubMed: 21385962
DOI: 10.1136/jnnp.2011.241612 -
Postgraduate Medicine Mar 1967
Topics: Diagnosis, Differential; Humans; Peripheral Nervous System Diseases
PubMed: 4289613
DOI: 10.1080/00325481.1967.11696135 -
Current Oncology Reports Oct 2017The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy. (Review)
Review
PURPOSE OF REVIEW
The purpose of this mini review is to evaluate the literature on B vitamins and chemotherapy-induced peripheral neuropathy.
RECENT FINDINGS
One hundred and five journal articles were evaluated and nine manuscripts were included. There was one in vitro, one was an animal and seven were human studies. The in vitro study was a safety study on vitamin B and oxaliplatin which was not directly related to CIPN. The animal study evaluated vitamin B on paclitaxel administration with positive results. The human studies varied using a vitamin B complex, vitamin B only and vitamin B. Chemotherapy-induced peripheral neuropathy (CIPN) continues to plague patients and the medical fraternity. Currently, there are still no conclusive protective or treatment options. B vitamins have been found to play a role in CIPN prevention, but further studies are required to ascertain possible protection and treatment options.
Topics: Animals; Humans; Neoplasms; Niacinamide; Organoplatinum Compounds; Oxaliplatin; Peripheral Nervous System Diseases; Vitamin B 12; Vitamin B 6; Vitamin B Complex
PubMed: 28983799
DOI: 10.1007/s11912-017-0636-z -
Scandinavian Journal of Gastroenterology Sep 2021Peripheral autonomic neuropathy, including enteric neuropathy, may be subtle and unrecognized for several years. Diagnosis of enteric neuropathy demands complicated...
PURPOSE
Peripheral autonomic neuropathy, including enteric neuropathy, may be subtle and unrecognized for several years. Diagnosis of enteric neuropathy demands complicated examinations such as full-thickness bowel biopsy. We hypothesized that knowledge about simultaneous occurrence of different types of neuropathy would lead to faster recognition and diagnosis of autonomic/enteric neuropathy. The aim of the present systematic review was to increase the awareness of disease groups causing autonomic and enteric neuropathy along with sensorimotor neuropathy.
METHODS
A systematic search strategy was used in PubMed, Embase and Web of Science. First, 4978 articles were identified. Review of titles/abstracts rendered exclusion of animal studies, articles not written in English or full-length, case reports, conference abstracts and duplicates until 357 articles remained. The full-length evaluation resulted in 35 studies (27 non-systematic reviews) which described objectively verified peripheral autonomic, enteric and sensorimotor neuropathy within the same disease.
RESULTS
Diabetes is the most common disease in society rendering generalized peripheral neuropathy. Accumulation of tissue deposits in amyloidosis, Lewy body disorders and sarcoidosis lead to widespread peripheral neuropathy. Several autoimmune disorders such as systemic sclerosis and primary Sjögren's syndrome present themselves with neuropathy. Paraneoplastic neuropathy may appear prior to symptoms from the malignancy. Both the infection , as well as the autoimmune response to the infection, i.e., Guillain-Barré syndrome, may lead to widespread peripheral neuropathy. Hereditary disorders with disturbed metabolism lead to intermittent attacks of neuropathy.
CONCLUSIONS
The major causes of generalized peripheral neuropathy are diabetes, diseases with tissue deposits, autoimmunity, infections, malignancy and metabolic diseases.
Topics: Animals; Autoimmune Diseases; Guillain-Barre Syndrome; Neoplasms; Nervous System Diseases; Peripheral Nervous System Diseases
PubMed: 34214006
DOI: 10.1080/00365521.2021.1942542 -
Biomarkers in Medicine Aug 2018Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxane treatment during chemotherapy. Identifying predictive biomarkers of CIPN would allow... (Review)
Review
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxane treatment during chemotherapy. Identifying predictive biomarkers of CIPN would allow physicians to alter treatment given to patients according to a personal risk of developing this condition. The current literature on CIPN biomarkers is reviewed, identifying biomarkers which have been found to be significantly related to CIPN. Three genetic biomarkers are identified (ARHGEF10 rs9657362, CYP2C8 rs11572080/rs10509681 and FGD4 rs10771973) which have been found to act as predictive CIPN biomarkers in multiple studies. Possible mechanisms underlying the relationship between these single nucleotide polymorphisms and CIPN development are explored. The biomarkers identified in this study should be investigated further to generate predictive biomarkers that may be used in a clinical setting.
Topics: Genetic Markers; Humans; Peripheral Nervous System Diseases; Polymorphism, Single Nucleotide; Predictive Value of Tests
PubMed: 30044129
DOI: 10.2217/bmm-2017-0427 -
Physical Medicine and Rehabilitation... Feb 2008Peripheral neuropathy, mononeuropathy and polyneuropathy, are not common in pregnancy. When complaints occur, however, even if minor, they can be bothersome to the... (Review)
Review
Peripheral neuropathy, mononeuropathy and polyneuropathy, are not common in pregnancy. When complaints occur, however, even if minor, they can be bothersome to the pregnant woman. Peripheral nerve function may threaten the mother and fetus in various ways during gestation. Quick recognition and treatment efforts should therefore be the clinician's goal. This article reviews peripheral neuropathy in pregnancy.
Topics: Cranial Nerve Diseases; Electrodiagnosis; Female; Humans; Peripheral Nervous System Diseases; Pregnancy; Pregnancy Complications
PubMed: 18194755
DOI: 10.1016/j.pmr.2007.10.004 -
Seminars in Oncology Nursing Aug 2007To review the evidence base for prevention and intervention of chemotherapy-induced peripheral neuropathy (PN). (Review)
Review
OBJECTIVES
To review the evidence base for prevention and intervention of chemotherapy-induced peripheral neuropathy (PN).
DATA SOURCES
Medical and nursing literature.
CONCLUSION
Many small studies that reported positive findings have either not been validated in large prospective, randomized controlled trials (RCT), or have not been further studied. Prevention strategies based on RCTs include the use of xaliproden to reduce the incidence of grade 3 PN in patients receiving oxaliplatin-based regimens, and dose reduction or interruption until recovery. There are gaps in the literature of nurse-sensitive outcome studies for nursing assessment and intervention
IMPLICATIONS FOR NURSING PRACTICE
Nurses need to be knowledgeable about the evidence, or lack of it, on strategies to prevent and manage chemotherapy-induced PN. Nurses also need to measure the effectiveness of interventions for PN, such as exercise, patient teaching about self-care strategies, and develop and/or participate in well-designed intervention studies regarding the prevention and management of PN.
Topics: Antineoplastic Agents; Humans; Peripheral Nervous System Diseases
PubMed: 17693343
DOI: 10.1016/j.soncn.2007.05.001 -
Oncology Nursing Forum Mar 2005To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy. (Review)
Review
PURPOSE/OBJECTIVES
To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy.
DATA SOURCES
Published abstracts, primary research literature, and textbook chapters.
DATA SYNTHESIS
Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used chemotherapeutic groups such as platinols, vinca alkaloids, and taxanes.
CONCLUSIONS
The nervous system has not been the focus of education or training for oncology nurses. Therefore, nurses' ability to educate patients regarding this aspect of their condition has been limited.
IMPLICATIONS FOR NURSING
With its significant impact on quality of life, peripheral neuropathy treatment and prevention are important components in the care of patients with cancer.
Topics: Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Humans; Neoplasms; Patient Education as Topic; Peripheral Nervous System Diseases; Quality of Life; Risk Factors
PubMed: 15759068
DOI: 10.1188/05.ONF.305-311 -
Postgraduate Medicine Jun 1996Peripheral neuropathy is common in the elderly and results in impairments in distal proprioception and strength that hinder balance and predispose them to falls. The... (Review)
Review
Peripheral neuropathy is common in the elderly and results in impairments in distal proprioception and strength that hinder balance and predispose them to falls. The loss of heel reflexes, decreased vibratory sense that improves proximally, impaired position sense at the great toe, and inability to maintain unipedal stance for 10 seconds in three attempts all suggest functionally significant peripheral neuropathy. Physicians can help their patients with peripheral neuropathy to prevent falls by teaching them and their families about peripheral nerve dysfunction and its effects on balance and by advising patients to substitute vision for the lost somatosensory function, correctly use a cane, wear proper shoes and orthotics, and perform balance and upper extremity strengthening exercises.
Topics: Accidental Falls; Aged; Foot; Humans; Peripheral Nervous System Diseases; Proprioception; Sensation Disorders
PubMed: 8668629
DOI: No ID Found -
Ginekologia Polska 2016Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most important neurologic complications experienced by patients receiving chemotherapy. The neuropathy... (Review)
Review
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most important neurologic complications experienced by patients receiving chemotherapy. The neuropathy often interferes with daily activities and exercise leading to severe impairment of the patient's quality of life (QoL). The evolution of most CIPNs is characterized by a gradual onset of signs/symptoms, beginning in the lower limbs and advancing proximally into a bilateral stocking and glove distribution. Patients often complain of numbness, tingling and pain in the affected areas. The symptoms become aggravated with repeated cycles of chemotherapy. When the offending agent is withheld, the symptoms generally abate, but relief is not guaranteed. The consequences of delay or discontinuation of treatment may affect overall patient survival.
Topics: Antineoplastic Agents; Female; Humans; Paresthesia; Peripheral Nervous System Diseases; Risk Factors
PubMed: 27321102
DOI: 10.17772/gp/61750