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Cutis Oct 2022
Topics: Humans; Petrolatum
PubMed: 36446090
DOI: 10.12788/cutis.0622 -
Journal of the American Academy of... Apr 2024Petrolatum, also known as petroleum jelly, is a widely used topical agent, with a variety of uses in dermatology. Despite its popularity, many myths surround this... (Review)
Review
Petrolatum, also known as petroleum jelly, is a widely used topical agent, with a variety of uses in dermatology. Despite its popularity, many myths surround this ubiquitous dermatologic staple. This review details the history of petrolatum and how it is manufactured as well as how its biologic properties make it a great moisturizer. Additionally, data on its potential for flammability, allergenicity, and comedogenicity are detailed, dispelling misconceptions about petrolatum use around oxygen and as a cause of acne. The uses and benefits of petrolatum in dermatology are wide-ranging-a patch test instrument, a vehicle for medicated ointments, and a wound care essential. Given its ubiquitous presence, it is important for dermatologists to understand the history, safety profile, and myths surrounding this humble skincare staple.
Topics: Humans; Petrolatum; Ointments; Allergens; Patch Tests
PubMed: 37315800
DOI: 10.1016/j.jaad.2023.06.010 -
The Journal of Allergy and Clinical... Apr 2016Petrolatum is a common moisturizer often used in the prevention of skin infections after ambulatory surgeries and as a maintenance therapy of atopic dermatitis (AD).... (Clinical Trial)
Clinical Trial
BACKGROUND
Petrolatum is a common moisturizer often used in the prevention of skin infections after ambulatory surgeries and as a maintenance therapy of atopic dermatitis (AD). However, the molecular responses induced by petrolatum in the skin have never been assessed.
OBJECTIVE
We sought to define the cutaneous molecular and structural effects induced by petrolatum.
METHODS
Thirty-six healthy subjects and 13 patients with moderate AD (mean SCORAD score, 39) were studied by using RT-PCR, gene arrays, immunohistochemistry, and immunofluorescence performed on control skin, petrolatum-occluded skin, and skin occluded with a Finn chamber only.
RESULTS
Significant upregulations of antimicrobial peptides (S100A8/fold change [FCH], 13.04; S100A9/FCH, 11.28; CCL20/FCH, 8.36; PI3 [elafin]/FCH, 15.40; lipocalin 2/FCH, 6.94, human β-defensin 2 [DEFB4A]/FCH, 4.96; P < .001 for all) and innate immune genes (IL6, IL8, and IL1B; P < .01) were observed in petrolatum-occluded skin compared with expression in both control and occluded-only skin. Application of petrolatum also induced expression of key barrier differentiation markers (filaggrin and loricrin), increased stratum corneum thickness, and significantly reduced T-cell infiltrates in the setting of "normal-appearing" or nonlesional AD skin, which is known to harbor barrier and immune defects.
CONCLUSIONS
Petrolatum robustly modulates antimicrobials and epidermal differentiation barrier measures. These data shed light on the beneficial molecular responses of petrolatum in barrier-defective states, such as AD and postoperative wound care.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Biomarkers; Case-Control Studies; Dermatitis, Atopic; Emollients; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Membrane Proteins; Middle Aged; Petrolatum; Skin; Young Adult
PubMed: 26431582
DOI: 10.1016/j.jaci.2015.08.013 -
International Journal of Clinical... Oct 2016The justification of the combination of vaseline and oxygen has been subject for discussion in many hospitals. Due to the lack of evidence based data in literature, we...
The justification of the combination of vaseline and oxygen has been subject for discussion in many hospitals. Due to the lack of evidence based data in literature, we have provided recommendations from a pharmacist's perspective. The use of petroleum-based products should be avoided when handling patients under oxygen therapy. Whenever a skin moisturizer is needed for lubrication or rehydration of dry nasal passages, the lips or nose when breathing oxygen, consider the use of oil-in water creams or water-based products.
Topics: Humans; Oxygen Inhalation Therapy; Petrolatum; Pharmacists; Professional Role
PubMed: 27480983
DOI: 10.1007/s11096-016-0365-7 -
International Journal of Pharmaceutics Apr 2018The rheological properties of petrolatum are dependent on both temperature and thermal history. How this thermal dependency can be explained is unclear. In the past it...
The rheological properties of petrolatum are dependent on both temperature and thermal history. How this thermal dependency can be explained is unclear. In the past it has been suggested that the structure of petrolatum consists of a three-dimensional crystalline network. This has been established using old microscopic techniques only. Therefore a study on the microstructure of petrolatum was conducted using rheometry, DSC, pulsed NMR, polarized light microscopy and synchrotron X-ray. The combination of these techniques show that petrolatum is composed of 21% solid material at room temperature. This consists of partly crystalline lamellar sheets which are packed in stacks. The occurrence of these lamellar sheets is temperature dependent and the number of lamellar stacks is dependent on thermal history. It was shown that rheological differences in petrolatum can be explained by the number of lamellar stacks present, where more lamellar stacks result in more rigid petrolatum.
Topics: Calorimetry, Differential Scanning; Crystallization; Drug Compounding; Excipients; Magnetic Resonance Spectroscopy; Microscopy, Polarization; Molecular Structure; Petrolatum; Rheology; Scattering, Small Angle; Structure-Activity Relationship; Synchrotrons; Technology, Pharmaceutical; Temperature; X-Ray Diffraction
PubMed: 29452154
DOI: 10.1016/j.ijpharm.2018.02.016 -
JAMA Dermatology Feb 2019
Topics: Administration, Topical; Blister; Drainage; Female; Follow-Up Studies; Humans; Middle Aged; Petrolatum; Shoulder; Skin Diseases, Vesiculobullous; Treatment Outcome
PubMed: 30540360
DOI: 10.1001/jamadermatol.2018.3277 -
Journal of Oleo Science Mar 2022Transdermal administration represents a major advancement over traditional pharmaceutical dosing methods. However, a frequent issue is inadequate penetration of the...
Transdermal administration represents a major advancement over traditional pharmaceutical dosing methods. However, a frequent issue is inadequate penetration of the active medicinal component through the skin. As a result, in the current research, we assessed the utility of newly developed petrolatum-liquid crystal (LC) ointment formulations and characterized their biocompatibility and function in the transdermal drug delivery system. To begin, we made petrolatum-LC formulations using p-aminobenzoic acid (PABA) as a hydrophilic model molecule. The viscosity, small-angle X-ray scattering (SAXS), particle diameters, and z-potential were measured to assess the physicochemical properties of the formulations. A dialysis release technique was used to evaluate medication release from petrolatum-LC formulations. In vitro testing was performed to determine the potential to enhance skin penetration. The biocompatibility of the produced formulations was further tested using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and single-cell gel electrophoresis. According to the results, the novel petrolatum-LC formulations are biocompatible and effective in forming hexosomes. PABA skin penetration was significantly enhanced by the new petrolatum-LC formulations. According to this study, petroleum-LC formulations are more efficient than commercial petrolatum in terms of skin permeability improvement and PABA skin concentration.
Topics: Administration, Cutaneous; Liquid Crystals; Petrolatum; Scattering, Small Angle; Skin; Skin Absorption; X-Ray Diffraction
PubMed: 35173089
DOI: 10.5650/jos.ess21344 -
Contact Dermatitis Dec 1978
Topics: Adult; Drug Eruptions; Humans; Male; Patch Tests; Petrolatum
PubMed: 153825
DOI: 10.1111/j.1600-0536.1978.tb03863.x -
American Journal of Pharmacy and the... Apr 1954
Topics: Bandages; Petrolatum
PubMed: 13158534
DOI: No ID Found -
Journal of the American Academy of... Nov 2018
Comparative Study
Topics: Abdomen; Administration, Topical; Catgut; Digestive System Surgical Procedures; Female; Humans; Male; Petrolatum; Reference Values; Skin Care; Wound Healing
PubMed: 29723559
DOI: 10.1016/j.jaad.2018.04.041