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Contact Dermatitis 2004
Topics: Allergens; Chemistry, Pharmaceutical; Drug Stability; Drug Storage; Humans; Nitriles; Ointment Bases; Patch Tests; Petrolatum; Time Factors
PubMed: 15606664
DOI: 10.1111/j.0105-1873.2004.0459g.x -
Ethiopian Medical Journal Oct 1978
Topics: Administration, Topical; Drug-Related Side Effects and Adverse Reactions; Glucocorticoids; Humans; Neomycin; Petrolatum; Promethazine
PubMed: 744194
DOI: No ID Found -
The British Journal of Dermatology Jan 1970
Topics: Alkalies; Humans; Permeability; Petrolatum; Skin; Skin Diseases; Solvents; Water
PubMed: 5410998
DOI: No ID Found -
Acta Poloniae Pharmaceutica 2015Electron paramagnetic resonance (EPR) spectroscopy was used for examination of free radicals in thermally treated vaselinum album (VA). Thermal treatment in hot air as...
Electron paramagnetic resonance (EPR) spectroscopy was used for examination of free radicals in thermally treated vaselinum album (VA). Thermal treatment in hot air as sterilization process was tested. Conditions of thermal sterilization were chosen according to the pharmaceutical norms. Vaselinum album was heated at the following conditions (T--temperature, t--time): T = 160°C and t = 120 min, T = 170°C and t = 60 min and T = 180°C and t = 30 min. The aim of this work was to determine concentration and free radical properties of thermally sterilized VA. EPR analysis for VA was done 15 min after sterilization. EPR measurements were done at room temperature. EPR spectra were recorded in the range of microwave power of 2.2-70 mW. g-Factor, amplitudes (A) and line width (ΔBpp) of the spectra were determined. The shape of the EPR spectra was analyzed. Free radical concentration (N) in the heated samples was determined. EPR spectra were not obtained for the non heated VA. EPR spectra were detected for all thermally sterilized samples. The spectra revealed complex character, their asymmetry depends on microwave power. The lowest free radicals concentration was found for the VA sterilized at 180°C during 30 min. EPR spectroscopy is proposed as the method useful for optimization of sterilization process of drugs.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Hot Temperature; Ointments; Petrolatum; Sterilization
PubMed: 26647625
DOI: No ID Found -
Journal of the American Academy of... Sep 2022
Topics: Humans; Bandages; Petrolatum; Pressure Ulcer
PubMed: 32835741
DOI: 10.1016/j.jaad.2020.08.072 -
Dermatitis : Contact, Atopic,... Sep 2005Isocyanates with the general formula R-(N=C=O) are theoretically contact sensitizers. However, allergic contact dermatitis (ACD) from isocyanates is seldom reported. In...
BACKGROUND
Isocyanates with the general formula R-(N=C=O) are theoretically contact sensitizers. However, allergic contact dermatitis (ACD) from isocyanates is seldom reported. In previous reports, patients reacted to their isocyanate-based work materials but not to commercial patch-test preparations of isocyanates. Therefore, we suspected that the low frequency of reported ACD from isocyanates was partly due to inadequate commercial preparations. A past study also showed the concentrations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in petrolatum preparations to be much lower than declared.
OBJECTIVE
In this study, 2,4-toluene diisocyanate (2,4-TDI), 1,6-hexamethylene diisocyanate (1,6-HDI), and isophorone diisocyanate (IPDI) were investigated in a similar fashion.
METHODS
In preparations from 12 dermatology departments and two suppliers of patch-test allergens, we determined the isocyanate content as the isocyanate-dibutylamine derivative, using liquid chromatography and mass spectrometry. The preparations were considered stable if the ratio between the stated and found concentrations was within the range of 0.8 to 1.2.
RESULTS
Although 28 of 36 investigated preparations had ratios outside of the stable range, they were in its vicinity, which indicates that preparations of 2,4-TDI, 1,6-HDI, and IPDI are more stable than are preparations of 4,4'-MDI where previously reported results showed ratios far outside of stable range.
CONCLUSION
As opposed to preparations of 4,4'-MDI, preparations of 2,4-TDI, 1,6-HDI, and IPDI can be considered to be stable.
Topics: Cyanates; Humans; Isocyanates; Patch Tests; Petrolatum; Reproducibility of Results; Toluene 2,4-Diisocyanate
PubMed: 16242085
DOI: No ID Found -
Cutis Jun 1986We describe two patients with an unusual, limited form of acne manifest as a single row of large, open comedones along the entire cutaneous margin of the upper lip. The...
We describe two patients with an unusual, limited form of acne manifest as a single row of large, open comedones along the entire cutaneous margin of the upper lip. The acne began after repetitive application to the lips of Chap Stick in one patient and petroleum jelly (Vaseline) in the other. It was treated successfully by eliminating the Chap Stick and petroleum jelly, respectively, as well as by microincision and expression of the comedones. Petrolatum, the major ingredient of Chap Stick, appears to be responsible for this type of acne.
Topics: Acne Vulgaris; Adolescent; Adult; Female; Humans; Petrolatum
PubMed: 2941247
DOI: No ID Found -
Archives of Dermatology Dec 1968
Topics: Animals; Bites and Stings; Cnidaria; Guinea Pigs; Injections, Intradermal; Methods; Petrolatum; Phenylephrine; Silicones; Triamcinolone; Urticaria
PubMed: 4386945
DOI: No ID Found -
Annals of Allergy 1948
Topics: Humans; Ointment Bases; Petrolatum; Sensitivity and Specificity
PubMed: 18886005
DOI: No ID Found -
Dermatologic Surgery : Official... Feb 2011
Comparative Study
Topics: Dermatology; Materials Testing; Petrolatum; Sutures; Tensile Strength
PubMed: 21324038
DOI: 10.1111/j.1524-4725.2010.01866.x