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Contact Dermatitis Feb 1978
Topics: Adult; Chronic Disease; Dermatitis, Contact; Humans; Male; Petrolatum; Pigmentation Disorders
PubMed: 657795
DOI: 10.1111/j.1600-0536.1978.tb03734.x -
Journal of Drugs in Dermatology : JDD Oct 2019Lanolin alcohol is a high cholesterol containing naturally derived material used as a skin protectant in wound healing petrolatum-based ointments. It is a highly... (Clinical Trial)
Clinical Trial
Lanolin alcohol is a high cholesterol containing naturally derived material used as a skin protectant in wound healing petrolatum-based ointments. It is a highly purified fraction of lanolin wool wax that has been identified as a possible cause of allergic contact dermatitis. This 3-center study enrolled 499 subjects who underwent a variety of in-office surgical procedures followed by application of a wound healing ointment containing lanolin alcohol without antibiotics. No allergic contact dermatitis was identified in the 499 subjects who completed the study. The lack of allergic contact dermatitis observed may be due to the proprietary highly purified lanolin alcohol utilized in the study formulation. This is not the lanolin alcohol preparation found on the standard dermatology patch test tray. Not all lanolin alcohols are equal. This is an important consideration when examining the reported incidence of allergic contact dermatitis to lanolin alcohol and the absence of allergic contact dermatitis demonstrated in this research. J Drugs Dermatol. 2019;18(10):1002-1004.
Topics: Adolescent; Adult; Aged; Cohort Studies; Dermatitis, Allergic Contact; Female; Humans; Lanolin; Male; Middle Aged; Ointment Bases; Ointments; Petrolatum; Prevalence; Surgical Wound; Treatment Outcome; Wound Healing; Young Adult
PubMed: 31584778
DOI: No ID Found -
European Journal of Dermatology : EJD 2002Various topical agents used in combination with phototherapy have blocking effects, however in contrast to in vitro studies there were not enough in vivo studies about... (Clinical Trial)
Clinical Trial
Various topical agents used in combination with phototherapy have blocking effects, however in contrast to in vitro studies there were not enough in vivo studies about this subject. Our purpose was to examine the photoprotective effects of white petrolatum and salicylic acid which can be used before UVB therapy in psoriasis patients. In 35 volunteers, a phototest was performed to determine the minimal erythema dose (MED) and the test was repeated with thin (0.1 cc/25 cm2) and thick (0.3 cc/25 cm2) petrolatum, thin and thick salicylic acid (20%) in petrolatum and sunscreen. After 24 hrs, the effects of each agent on MED was investigated. MED values detected after pure UVB and after application of topical agents were compared one by one, and the differences between all of them have been found statistically significant. These showed that MED values were increased by thin or thick petrolatum and also by thin and thick salicylic acid (20%) in petrolatum. The highest MED values were detected with thick salicylic acid in petrolatum followed by thin salicylic acid in petrolatum, thick petrolatum and thin petrolatum. The application of petrolatum and salicylic acid, which can block UVB, before phototherapy is not recommended.
Topics: Emollients; Erythema; Humans; Keratolytic Agents; Petrolatum; Psoriasis; Salicylic Acid; Single-Blind Method; Skin; Ultraviolet Therapy
PubMed: 11872412
DOI: No ID Found -
Nursing Older People Sep 2004
Topics: Humans; Oxygen Inhalation Therapy; Petrolatum
PubMed: 15470848
DOI: 10.7748/nop.16.6.41.s19 -
Anesthesia and Analgesia Oct 1986
Topics: Cautery; Chlorobutanol; Drug Combinations; Eye; Lanolin; Mineral Oil; Ointments; Petrolatum
PubMed: 3752564
DOI: 10.1213/00000539-198610000-00025 -
The Western Journal of Medicine Aug 1983Psoriasis is a common papulosquamous skin disease which frequently presents a therapeutic challenge to physicians. Topical therapy with steroids, coal tars and anthralin... (Comparative Study)
Comparative Study Review
Psoriasis is a common papulosquamous skin disease which frequently presents a therapeutic challenge to physicians. Topical therapy with steroids, coal tars and anthralin are effective when used properly for many patients. More severely affected patients may require phototherapy using coal tars and anthralin plus ultraviolet radiation. Systemic methotrexate administration is indicated for some patients with severe skin and arthropathic psoriasis. Treatment using psoralen and long-wavelength ultraviolet phototherapy has recently been approved and is effective in many patients, but long-term safety remains a question. Synthetic retinoids are experimental drugs currently being evaluated for severe forms of psoriasis.
Topics: Coal Tar; Evaluation Studies as Topic; Glucocorticoids; Humans; Methotrexate; PUVA Therapy; Petrolatum; Psoriasis; Retinoids; Ultraviolet Therapy
PubMed: 6195826
DOI: No ID Found -
Ostomy/wound Management Dec 2005Petrolatum-based ointments often are used to treat and prevent incontinence dermatitis. However, anecdotal reports indicate that petrolatum ointments may affect the... (Comparative Study)
Comparative Study Randomized Controlled Trial
Petrolatum-based ointments often are used to treat and prevent incontinence dermatitis. However, anecdotal reports indicate that petrolatum ointments may affect the absorbency of disposable briefs also commonly used in incontinence management. To examine whether petrolatum ointments clog a commonly used absorbent brief, a randomized, balanced-block design study was conducted in a controlled laboratory setting to compare the brief-clogging potential of three petrolatum ointments to a non-alcohol barrier film. Test products were applied to 6-cm x 6-cm test sites on the volar forearms of 16 volunteers. Pre-weighed mini briefs were applied to the test sites in a manner that simulates normal brief wear. After 5 minutes of wear, the mini briefs were weighed to determine percent of product transfer from skin to mini brief. The mini briefs then were reapplied to the same test sites and a synthetic urine solution was introduced between the skin and the mini brief. Mini briefs subsequently were removed to determine fluid uptake by weight. Results indicate significant differences between the four test products (P < 0.01) both in percent transfer and in mini brief fluid absorption. From 59% to 69% of the petrolatum-based products transferred from the skin to the mini briefs and a 54% to 90% reduction in fluid uptake was noted, as determined by weight. The non-alcohol barrier film did not transfer to the mini brief and fluid uptake was minimally affected. Further study in the clinical and practice settings to determine the effect and consequences of barrier product transfer on absorbent garments is warranted.
Topics: Absorption; Adult; Analysis of Variance; Diapers, Adult; Emollients; Equipment Failure; Humans; Petrolatum; Skin Care; Urinary Incontinence
PubMed: 16439811
DOI: No ID Found -
American Industrial Hygiene Association... 1963
Topics: Alkanes; Petrolatum; Petroleum; Solvents
PubMed: 14042499
DOI: 10.1080/00028896309343241 -
The New England Journal of Medicine Nov 1977
Topics: Athletic Injuries; Breast; Female; Humans; Jogging; Nipples; Petrolatum
PubMed: 909575
DOI: 10.1056/NEJM197711172972018 -
Allergy Sep 2004We report on an unexpected sensitization to petrolatum diagnosed with the occurrence of multiple nonrelevant and false-positive drug patch-tests performed while...
We report on an unexpected sensitization to petrolatum diagnosed with the occurrence of multiple nonrelevant and false-positive drug patch-tests performed while investigating a patient suffering from many cutaneous adverse drug reactions. All the positive drug patch-tests were prepared with GILBERT vaseline. This petrolatum reaction is positive as it was tested with five other brands of petrolatums a few months later. As the same petrolatums, but from different batches were tested, patch-tests with GILBERT petrolatum were doubtful, while other petrolatums were positive. White petrolatum is a mixture of semisolid hydrocarbons of the methane series. The sensitizing impurities of petrolatum are polycyclic aromatic hydrocarbons, e.g. phenanthrene derivatives. The purity of petrolatum depends on both the petroleum stock and on the production and packaging methods. Even if rare, contact sensitization to petrolatum can disturb the interpretation of drug patch-tests. It is necessary in the interpretation of drug patch-tests to test both in petrolatum and other vehicles and with all the different petrolatums used in preparing the material for drug patch-tests. So, it is essential to advise the patients sensitized to petrolatum to remove all the topical drugs, such as all the cosmetics, which contain petrolatum in their formulation.
Topics: Dermatitis, Contact; False Positive Reactions; Female; Humans; Middle Aged; Patch Tests; Petrolatum
PubMed: 15291911
DOI: 10.1111/j.1398-9995.2004.00452.x