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Journal of the American Academy of... Dec 2003Exogenous lipoid pneumonia is a well-described entity in the literature. To our knowledge, this is the first reported case that occurred secondary to external...
Exogenous lipoid pneumonia is a well-described entity in the literature. To our knowledge, this is the first reported case that occurred secondary to external application of petrolatum to the face for erythrodermic psoriasis.
Topics: Administration, Cutaneous; Facial Dermatoses; Female; Humans; Middle Aged; Petrolatum; Pneumonia, Lipid; Psoriasis
PubMed: 14639399
DOI: 10.1016/s0190-9622(03)00445-6 -
Urology Jun 1977
Topics: Lubrication; Petrolatum; Urinary Catheterization
PubMed: 883064
DOI: 10.1016/0090-4295(77)90313-2 -
The Journal of Dermatology Apr 1976Medicinal grade yellow and white petrolatum (soft paraffin) were tested for dermatoxic effects on laboratory animals and man. Yellow petrolatum produced redness,... (Clinical Trial)
Clinical Trial
Medicinal grade yellow and white petrolatum (soft paraffin) were tested for dermatoxic effects on laboratory animals and man. Yellow petrolatum produced redness, thickening of skin, hyperkeratosis and reversible total hair loss in rabbit and rat but no dermatoxic effect was observed in man and dog. White petrolatum which is similar in composition to yellow petrolatum produced less redness and keratosis. Refluxing of yellow soft paraffin with 95% alcohol could dissolve out dermatoxic fraction. The results have been discussed and it is suggested that drugs with petrolatum as ointment base should not be tested on rats and rabbits as petrolatum itself is dermatoxic in these species.
Topics: Administration, Cutaneous; Animals; Dogs; Humans; Ointment Bases; Petrolatum; Rabbits; Rats; Skin
PubMed: 15636544
DOI: 10.1111/j.1346-8138.1976.tb00970.x -
Contact Dermatitis Jan 1980
Topics: Dermatitis, Contact; Humans; Immunization; Patch Tests; Petrolatum; Pharmaceutical Vehicles; Skin Tests
PubMed: 7398273
DOI: No ID Found -
Contact Dermatitis Sep 1995
Topics: Adult; Eczema; Female; Humans; Patch Tests; Petrolatum; Skin
PubMed: 8565468
DOI: 10.1111/j.1600-0536.1995.tb00550.x -
Khirurgiia 2019To present treatment strategy for large volumes of injectable non-absorbable 'shell-less' soft tissue fillers (vaseline, synthol, silicone etc.).
AIM
To present treatment strategy for large volumes of injectable non-absorbable 'shell-less' soft tissue fillers (vaseline, synthol, silicone etc.).
MATERIAL AND METHODS
The authors present an experience of surgical treatment of 8 patients who underwent injections of medical vaseline (breast augmentation, n=5) and synthol (muscles enlargement, n=3) and review of the current literature devoted to this problem.
RESULTS
Injection of large amounts (over 50 ml) of non-absorbable fillers into soft tissues is unacceptable and leads to numerous complications. Oil-based 'shell-less' fillers cannot be removed by minimally invasive techniques (puncture, mini-incisions, etc.) due to multiple diffuse lesions in the form of oleogranulomas (cysts of different size) and surrounding widespread inflammation and fibrosis of tissues. Surgery is the only adequate method. However, this approach is followed by scars and often tissue contour deformation. Migration of these fillers to other anatomical areas (from the neck to the lower extremities) significantly complicates the situation, treatment and results. In case of categorical refusal of patients from surgical treatment and no complaints, they should be properly informed about possible consequences and complications and dynamic medical supervision is necessary. Intraoperative ultrasound examination is useful for the control of radical removal of pathological areas. Timely removal of non-absorbable fillers allows to avoid serious complications and to achieve good aesthetic results.
Topics: Cosmetic Techniques; Dermal Fillers; Fibrosis; Humans; Inflammation; Injections; Oils; Petrolatum
PubMed: 31120446
DOI: 10.17116/hirurgia201904142 -
The Journal of Investigative Dermatology Aug 1948
Topics: Bentonite; Ointment Bases; Ointments; Petrolatum
PubMed: 18877038
DOI: 10.1038/jid.1948.77 -
Advance For Nurse Practitioners Jun 2004
Review
Topics: Acetic Acid; Dermatomycoses; Drug Combinations; Foot Dermatoses; Household Products; Humans; Petrolatum; Plant Extracts; Plant Oils; Self Care; Skin Care; Terpenes
PubMed: 15218592
DOI: No ID Found -
Contact Dermatitis Aug 2004Diphenylmethane diisocyanate (MDI) is widely used in its polymeric form in the manufacturing of polyurethane products. Previous reports on MDI-related contact allergy...
Diphenylmethane diisocyanate (MDI) is widely used in its polymeric form in the manufacturing of polyurethane products. Previous reports on MDI-related contact allergy have shown a pattern, where patients seem to react to their own MDI-based work material but not to commercial patch-test preparations, which contain 4,4'-MDI. Therefore, we performed chemical analyses of 14 commercial test preparations of 4,4'-MDI obtained from 8 European and 4 American dermatology departments as well as 2 preparations from 2 major European suppliers of patch-test allergens. A new method for monitoring 4,4'-MDI in petrolatum preparations was developed and the determination of 4,4'-MDI as the MDI-dibutylamine derivative using liquid chromatography-mass spectrometry was performed. None of the preparations obtained from the dermatology departments contained more than 12% of the concentration stated on the label. In most cases, 4,4'-MDI content was only a few percentages or less of the concentration stated. 7 of the 14 preparations were analysed before the expiry date. Yet, only 1 of them, a preparation directly obtained from the supplier, came close to the concentration stated on the label. Thus, using these preparations, patients will be tested with a lower concentration than intended, leading to possible false-negative reactions.
Topics: Allergens; Dermatitis, Allergic Contact; Emollients; False Negative Reactions; Gas Chromatography-Mass Spectrometry; Humans; Isocyanates; Patch Tests; Petrolatum
PubMed: 15373847
DOI: 10.1111/j.0105-1873.2004.00404.x -
Acta Veterinaria Scandinavica Jun 2011Treatment and protection of wounds in horses can be challenging; protecting bandages may be difficult to apply on the proximal extremities and the body. Unprotected... (Randomized Controlled Trial)
Randomized Controlled Trial
BACKGROUND
Treatment and protection of wounds in horses can be challenging; protecting bandages may be difficult to apply on the proximal extremities and the body. Unprotected wounds carry an increased risk of bacterial contamination and subsequent infection which can lead to delayed wound healing. Topical treatment with antimicrobials is one possibility to prevent bacterial colonization or infection, but the frequent use of antimicrobials ultimately leads to development of bacterial resistance which is an increasing concern in both human and veterinary medicine.
METHODS
Standardized wounds were created in 10 Standardbred mares. Three wounds were made in each horse. Two wounds were randomly treated with LHP® or petrolatum and the third wound served as untreated control. All wounds were assessed daily until complete epithelization. Protocol data were recorded on day 2, 6, 11, 16, 21 and 28. Data included clinical scores for inflammation and healing, photoplanimetry for calculating wound areas and swab cytology to assess bacterial colonization and inflammation. Bacterial cultures were obtained on day 2, 6 and 16.
RESULTS
Mean time to complete healing for LHP® treated wounds was 32 days (95%CI=26.9-37.7). Mean time to complete healing for petrolatum and untreated control wounds were 41.6 days (95%CI=36.2-47.0) and 44.0 days (95%CI=38.6-49.4) respectively. Wound healing occurred significantly faster in LHP® wounds compared to both petrolatum (p=0.0004) and untreated controls (p<0.0001). There was no significant difference in time for healing between petrolatum and untreated controls. Total scores for bacteria and neutrophils were significantly (p<0.0001) lower for LHP® treated wounds compared to petrolatum from day 16 and onwards. Staphylococcus aureus and Streptococcus zooepidemicus were only found in cultures from petrolatum treated wounds and untreated controls.
CONCLUSIONS
Treatment with LHP® reduced bacterial colonization and was associated with earlier complete wound healing. LHP® cream appears to be safe and effective for topical wound treatment or wound protection.
Topics: Administration, Cutaneous; Animals; Anti-Infective Agents, Local; Bacteria; Emollients; Epithelium; Female; Horses; Hydrogen Peroxide; Inflammation; Neck Injuries; Petrolatum; Random Allocation; Wound Healing
PubMed: 21718487
DOI: 10.1186/1751-0147-53-45