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Journal of Pharmaceutical Sciences Mar 1985The effects of temperature and mechanical shear on the microcrystalline structure of petrolatum are examined; syneresis determinations and rheological methods are...
The effects of temperature and mechanical shear on the microcrystalline structure of petrolatum are examined; syneresis determinations and rheological methods are utilized as indicators of the integrity of this structure. Two simple and practical methods for determining the shear sensitivity of petrolatum are presented. The rheological technique of spring relaxation is evaluated and shown to be more valuable than the continuous rheogram data in predicting the microcrystalline structure of petrolatum.
Topics: Chemical Phenomena; Chemistry, Physical; Crystallization; Petrolatum; Rheology; Temperature; Viscosity
PubMed: 4009436
DOI: 10.1002/jps.2600740313 -
European Journal of Internal Medicine Jul 2018
Topics: Humans; Lung; Male; Middle Aged; Petrolatum; Pneumonia, Lipid; Recurrence; Tomography, X-Ray Computed
PubMed: 29402508
DOI: 10.1016/j.ejim.2017.12.018 -
Journal of Drugs in Dermatology : JDD Aug 2013
Topics: Dermatologic Agents; Humans; Mohs Surgery; Ointment Bases; Petrolatum; Postoperative Care; Wounds and Injuries
PubMed: 23986156
DOI: No ID Found -
Cutis Jul 1981
Topics: Cosmetics; Drug Hypersensitivity; Humans; Male; Patch Tests; Petrolatum; Skin Tests
PubMed: 7261669
DOI: No ID Found -
Archiv Der Pharmazie Und Berichte Der... Nov 1970
Topics: Mineral Oil; Paraffin; Petrolatum; Viscosity
PubMed: 5275888
DOI: 10.1002/ardp.19703031103 -
Journal of Microencapsulation 1996Liposornes used for topical applications are often incorporated into a vehicle to achieve suitable viscosity and application properties. The effect of incorporation of...
Liposornes used for topical applications are often incorporated into a vehicle to achieve suitable viscosity and application properties. The effect of incorporation of liposomes into white petrolatum as a possible dermatological base was investigated. A number of formulae were developed to determine the type of petrolatum base that would be compatible with the liposomes. The physical appearance and stability of the vaseline-liposome (VL) preparations were determined by organoleptic analysis and microscopy. The effect of petrolatum base on the drug release from the liposomes was determined in a flow-through diffusion cell system using a model silastic polymer membrane as barrier. A base containing white petrolatum 46.7% (w/w), stearyl alcohol 6.7% (w/w), cholesterol 13.3 (w/w), Tween 80 16.7% (w/w) and Span 16.7% (w/w) was selected for diffusion studies, since the mixture of this base and liposome preparation, at 1:1.9 (w/w) ratios, provided a stable, dermatologically acceptable dosage form, in which the liposomes were uniformly distributed and their structures were preserved. Diffusion studies showed that the drug release rate decreases 2.5x when the liposomes are incorporated into the vaseline base; however, after a temporary decrease they seem to extend the duration of release beyond that of the original liposomal formula. These studies revealed a possibility of using white petrolatum in the topical application of liposomes.
Topics: Administration, Topical; Capsules; Cholesterol; Dermatology; Diffusion; Drug Carriers; Kinetics; Lipid Metabolism; Liposomes; Microscopy; Petrolatum; Phospholipids; Skin; Tetracaine
PubMed: 8864995
DOI: 10.3109/02652049609026043 -
Actas Dermo-sifiliograficas Jan 2020
Topics: Adult; Buttocks; Cellulitis; Dermal Fillers; Granuloma, Foreign-Body; Humans; Male; Mineral Oil; Petrolatum; Recurrence
PubMed: 31005232
DOI: 10.1016/j.ad.2018.06.018 -
Contact Dermatitis Aug 1976Common emulsifiers were tested in over 1,200 patients with eczema. Triethanolamine stearate tested at 5% in petrolatum caused irritant reactions in 9.5% of the patients....
Common emulsifiers were tested in over 1,200 patients with eczema. Triethanolamine stearate tested at 5% in petrolatum caused irritant reactions in 9.5% of the patients. On the other hand, non-ionic emulsifying agents tested at 10-20% produced irritation in only a few cases. Allergic reactions were found in 2.1% of those tested. Lanette, sorbitan sesquioleate, the Spans, polyoxyethylene oxypropylene stearate, polyoxyethylene sorbitol lanolin derivative, and triethanolamine stearate each elicited allergic reactions in 0.3-0.7% of the cases. The Tweens caused an allergy in only two cases, but glycerol monostearate caused no reaction at all. Five out of six patients sensitive to sorbitan sesquioleate reacted positively to the Spans as well. The patients allergic to one or more emulsifiers were also sensitive to several other substances included in our routine test series with the exception of four patients who reacted only to the emulsifying agents.
Topics: Dermatitis, Contact; Emulsions; Ethanolamines; Female; Humans; Male; Ointment Bases; Patch Tests; Petrolatum; Surface-Active Agents
PubMed: 1021350
DOI: 10.1111/j.1600-0536.1976.tb03027.x -
Toxicology and Applied Pharmacology Jan 1966
Topics: Animals; Carcinoma, Squamous Cell; Female; Male; Mice; Petrolatum; Skin Neoplasms
PubMed: 5921887
DOI: 10.1016/0041-008x(66)90107-4 -
Journal of Pharmaceutical and... Jun 2002The effects of gamma irradiation on petrolatum eye ointment base (EOB) and its ingredients (white petrolatum, liquid paraffin, and wool fat) were studied at different...
The effects of gamma irradiation on petrolatum eye ointment base (EOB) and its ingredients (white petrolatum, liquid paraffin, and wool fat) were studied at different irradiation doses. Forty-one volatile radiolysis products were detected and identified by a combined system of headspace-gas chromatography-mass spectrometry (HS-GC-MS). The characteristics of the radiolysis products and the degradation pathway were discussed in each case, respectively. GC method demonstrates that the component distribution patterns of eye ointment as well as its individual ingredients have no differences before and after gamma irradiation. The influence of gamma treatment on EOB was quantitatively determined at 15, 25 and 50 kGy. The concentrations of the radiolysis products increase linearly with increasing doses. Both qualitative and quantitative data show that irradiated eye ointment is safe for human use.
Topics: Gamma Rays; Gas Chromatography-Mass Spectrometry; Ointment Bases; Petrolatum; Pulse Radiolysis
PubMed: 12062686
DOI: 10.1016/s0731-7085(02)00017-1