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Journal of Drugs in Dermatology : JDD Jan 2013An excess of 70 million cutaneous surgical procedures are conducted annually in the United States that may result in scarring. Skin scars are a normal outcome of the... (Comparative Study)
Comparative Study Randomized Controlled Trial
An excess of 70 million cutaneous surgical procedures are conducted annually in the United States that may result in scarring. Skin scars are a normal outcome of the tissue repair process. However, individuals with abnormal scarring may have aesthetic, psychological, and social consequences. As a result, there is a high patient demand for products that will reduce the scarring. The principles underlying scar formation are now better understood. Products are being developed to address those critical components of the wound-healing process, namely inflammation, hydration, and collagen maturation. A multicomponent scar product was previously shown effective in preventing exaggerated scarring in patients undergoing various surgical procedures. The present outpatient study was conducted in patients undergoing shave biopsies. Following reepithelialization, this investigator-blinded, randomized, 8-week trial compared twice-daily application of either the scar product or the standard of care, white petrolatum. Evaluation visits were conducted at baseline and at weeks, 1, 2, 4 and 8. Subjects were evaluated by the blinded investigator for clinical efficacy and tolerability using grading scales. Standardized digital photographs were taken at each visit, and subjects completed a self-assessment questionnaire regarding treatment effectiveness and satisfaction. Twenty-eight subjects completed the 8-week study. The scar product provided earlier improvements than the white petrolatum. At week 1, 70% of subjects receiving the scar product demonstrated at least 50% global improvement in scar appearance vs only 42% of the subjects receiving white petrolatum. The more rapid improvement was accompanied by greater reductions in stinging/burning and itching with the scar product at all visits. Importantly, there was also greater subject satisfaction with the scar product at all visits. This scar product may be useful in hastening the healing of cutaneous shave biopsies and reducing the stinging/burning and itching associated with the normal healing process.
Topics: Adult; Aged; Biopsy; Centella; Cicatrix; Diagnostic Self Evaluation; Double-Blind Method; Emollients; Female; Gels; Humans; Iridoid Glucosides; Iridoids; Male; Middle Aged; Petrolatum; Plant Extracts; Pruritus; Pyrans; Regional Blood Flow; Sensation; Skin; Skin Pigmentation; Vasodilator Agents; Young Adult
PubMed: 23377333
DOI: No ID Found -
Plastic and Reconstructive Surgery May 2004
Topics: Adult; Female; Granuloma, Foreign-Body; Humans; Injections; Paraffin; Petrolatum; Vulva
PubMed: 15114185
DOI: 10.1097/01.prs.0000119883.13883.11 -
Ophthalmology. Retina Mar 2023
Topics: Humans; Petrolatum; Lip; Retinal Artery Occlusion; Ophthalmic Artery
PubMed: 36646579
DOI: 10.1016/j.oret.2022.12.006 -
Journal of the American Pharmaceutical... Dec 1957
Topics: Diffusion; In Vitro Techniques; Ointment Bases; Ointments; Petrolatum; Pharmaceutical Preparations; Silicones
PubMed: 13491488
DOI: 10.1002/jps.3030461202 -
Journal of the American Academy of... Aug 2008
Topics: Cantharidin; Dermatitis, Contact; Enzyme Inhibitors; Female; Humans; Infant; Molluscum Contagiosum; Petrolatum
PubMed: 18625390
DOI: 10.1016/j.jaad.2008.03.025 -
Journal of Pharmaceutical and... Oct 1996
Topics: Chromatography, Gas; Emollients; Petrolatum; Solvents
PubMed: 8895085
DOI: 10.1016/0731-7085(96)01809-2 -
Die Pharmazie May 1972
Topics: Microscopy, Electron; Ointments; Particle Size; Petrolatum
PubMed: 4647560
DOI: No ID Found -
Journal of the American Academy of... May 1992Paraffinoma is a well-recognized complication of paraffin injection. We describe a 44-year-old man who had an ethmoidectomy for chronic sinusitis. A communicating...
Paraffinoma is a well-recognized complication of paraffin injection. We describe a 44-year-old man who had an ethmoidectomy for chronic sinusitis. A communicating fracture of the ethmoid bone into the orbit occurred intraoperatively. The nasal cavity was subsequently packed with gauze containing a petrolatum-based antibiotic ointment. Bilateral, periocular swelling developed 1 week later. Optical and electron microscopic studies revealed a paraffinoma.
Topics: Administration, Intranasal; Adult; Anti-Bacterial Agents; Chronic Disease; Ethmoid Bone; Ethmoid Sinusitis; Eyelid Diseases; Granuloma, Foreign-Body; Humans; Intraoperative Complications; Male; Ointment Bases; Orbital Diseases; Petrolatum; Skull Fractures; Wound Infection
PubMed: 1613145
DOI: 10.1016/0190-9622(92)70116-w -
Pediatrics May 2000An increase in the incidence of systemic candidiasis (SC) followed a change in skin care for extremely low birth weight (ELBW) infants in our neonatal intensive care...
BACKGROUND AND OBJECTIVE
An increase in the incidence of systemic candidiasis (SC) followed a change in skin care for extremely low birth weight (ELBW) infants in our neonatal intensive care unit (NICU). We sought to determine whether the use of topical petrolatum ointment (TPO) for skin care of ELBW infants was associated with risk for SC.
STUDY DESIGN
Case-control study.
SETTING
A 48-bed NICU in a private hospital in Houston, Texas.
PATIENTS
Ten ELBW infants with and 30 without SC admitted to the NICU from December 1, 1997 through July 31, 1998.
METHODS
ELBW infants with SC were identified using hospital microbiology and infectious disease consultation databases. A case was defined as an infant weighing =1000 g at birth with Candida spp isolated from a normally sterile body site. Three infants without SC were matched to each case by birth weight, admission date, and survival to the age of SC onset for the case. Data were collected by retrospective medical record review. Molecular analysis of Candida isolates was performed by karyotyping and restriction fragment length polymorphism using pulsed-field gel electrophoresis.
RESULTS
Case infants had a mean (+/- standard deviation) age of onset of 21.5 +/- 24 days. Infants with SC and controls did not differ in birth weight, gestational age, or duration of therapy with steroids, antibiotics, insulin, or total parenteral nutrition. Although cases were more likely to be born vaginally and had a longer duration endotracheal intubation than controls, these differences were not significant. The odds ratio for skin care with TPO in case infants versus control infants was 11 (95% confidence interval: 1.9-63). Skin care with TPO was discontinued and the incidence of SC decreased to baseline. Several Candida spp and genetic profiles were identified, suggesting that there was not a common source outbreak.
CONCLUSIONS
We conclude that the use of TPO promoted an increase in the incidence of SC in ELBW infants. Additional investigation of potential infectious risks for ELBW infants receiving TPO skin care is warranted.
Topics: Administration, Topical; Candidiasis; Case-Control Studies; Humans; Incidence; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Ointment Bases; Ointments; Petrolatum
PubMed: 10790460
DOI: 10.1542/peds.105.5.1041 -
Dermatology (Basel, Switzerland) 2000Cutaneous problems are commonly associated with the use of diapers. Aiming to help reduce them, we have explored the use of the inner layer of diapers as a means to... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
BACKGROUND
Cutaneous problems are commonly associated with the use of diapers. Aiming to help reduce them, we have explored the use of the inner layer of diapers as a means to deliver to the skin dermatological formulations intended to help protect it from overhydration and irritation.
OBJECTIVE
To determine the feasibility of using the inner layer of the diaper as a vehicle for topical delivery of a petrolatum-based formulation and to determine its impact on skin surface microtopography.
METHODS
Two independent, blinded, randomized clinical trials were conducted, on children 16-24 months of age. All comparisons were done versus a control diaper, identical to the test product except for the absence of the petrolatum formulation. The studies determined the effects of the novel diaper on transfer of formulation to the skin and skin surface microtopography.
RESULTS
During normal diaper use, formulation transfer from the diaper to the skin occurred in a cumulative, time-dependent manner and use of the formulation-treated diaper was associated with significant reductions in skin surface roughness compared to the control diaper.
CONCLUSIONS
The results demonstrated the feasibility and skin surface benefits associated with continuous topical administration of a petrolatum-based formulation by this novel diaper. This unprecedented dosimetric approach offers new avenues to reduce further the dermatological problems commonly associated with diaper use.
Topics: Administration, Topical; Analysis of Variance; Child, Preschool; Double-Blind Method; Female; Humans; Infant; Infant Care; Male; Ointment Bases; Petrolatum; Skin; Skin Care; Skin Physiological Phenomena; Time Factors
PubMed: 10828632
DOI: 10.1159/000018365