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Zeitschrift Fur Die Gesamte Innere... Jan 1958
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Phenacetin
PubMed: 13544353
DOI: No ID Found -
Godisen Zbornik Na Medicinskiot... 1969
Topics: Humans; Nephritis; Phenacetin
PubMed: 5200027
DOI: No ID Found -
Journal of the American Geriatrics... Sep 1970
Topics: Diabetes Complications; Humans; Kidney Papillary Necrosis; Phenacetin; Pyelonephritis; Substance-Related Disorders; Urinary Calculi
PubMed: 5458752
DOI: 10.1111/j.1532-5415.1970.tb02817.x -
New York State Journal of Medicine Nov 1961
Topics: Phenacetin
PubMed: 14450767
DOI: No ID Found -
Ugeskrift For Laeger Dec 1957
Topics: Humans; Phenacetin; Pyelonephritis
PubMed: 13530315
DOI: No ID Found -
Science (New York, N.Y.) Mar 1972The amount of phenacetin in plasma was determined in nine control subjects (nonsmokers) and nine subjects who smoked at least 15 cigarettes per day. The mean plasma...
The amount of phenacetin in plasma was determined in nine control subjects (nonsmokers) and nine subjects who smoked at least 15 cigarettes per day. The mean plasma concentration of phenacetin at 1, 2, 3(1/2), and 5 hours after its administration was markedly lower in cigarette smokers than in nonsmokers. At 2 hours after the oral administration of 900 milligrams of phenacetin, the plasma concentration (+/- standard error) of unchanged drug was 2.24 +/- 0.73 micrograms per milliliter in the controls and 0.48 +/- 0.28 micrograms per milliliter in the smokers. The rate of excretion in urine of the major metabolite of phenacetin, N-acetyl-p-aminophenol, was the same in both groups. These results indicate for the first time decreased concentrations of a drug in plasma of persons who smoke cigarettes, and the results suggest that the decrease in the amount of Phenacetin in plasma may result from increased metabolism of phenacetin in cigarette smokers.
Topics: Acetaminophen; Administration, Oral; Adult; Chromatography, Gas; Female; Humans; Male; Phenacetin; Smoking; Time Factors
PubMed: 5061244
DOI: 10.1126/science.175.4027.1248 -
Clinical Pharmacology and Therapeutics Dec 1976There were marked individual differences in the plasma levels of phenacetin after oral administration of a 900-mg dose to 9 normal volunteers eating customary home diet.... (Comparative Study)
Comparative Study
There were marked individual differences in the plasma levels of phenacetin after oral administration of a 900-mg dose to 9 normal volunteers eating customary home diet. Feeding a diet that contained charcoal-broiled beef for 4 days prior to the administration of phenacetin markedly decreased the plasma levels of this drug without appreciably influencing the plasma concentrations of phenacetin's metabolite, N-acetyl-p-aminophenol (APAP), or the plasma half-life of phenacetin. The average peak concentration of phenacetin in plasma, after a 900-mg oral dose, fell from 1,628 ng/ml, when the subjects were fed a control diet for 7 days, to 352 ng/ml after they were fed the same diet which contained charcoal-broiled beef for 4 days. The average peak concentration of phenacetin rose to 1,885 ng/ml after the subjects were subsequently fed the control diet for 7 days. The ratios of the average concentrations of APAP in plasma to those of phenacetin markedly increased after the charcoal-broiled beef diet. The results suggest that a diet containing charcoal-broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver. This effect greatly decreases the bioavailability of phenacetin.
Topics: Acetaminophen; Adult; Charcoal; Cooking; Diet; Female; Humans; Male; Meat; Phenacetin; Time Factors
PubMed: 991534
DOI: 10.1002/cpt1976206633 -
Drug Testing and Analysis Mar 2017Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It...
Phenacetin is a pharmaceutical closely related to acetaminophen that has been banned in France for a long time due to its nephritic and carcinogenic adverse effects. It frequently appears in cocaine seizures as a cutting agent. Following both sanitary and intelligence motivations, this molecule was chosen for this study, and stable isotopes seemed to be the most appropriate tool. A total of 228 seized samples were collected over a 6-year period, and 8 standards of known origin were purchased. They were submitted to gas chromatography (GC) or elemental analysis - isotope ratio mass spectrometry (EA-IRMS) measurements, depending on their complexity. Stable isotope ratios of carbon, hydrogen, and nitrogen for a part of the sample set, were acquired. The isotopic values of phenacetin standards acquired from various providers located worldwide are quite spread, which indicates that stable isotopes could be used to discriminate manufacturers. However, the measured values of most of the seized samples are concentrated in a narrow range, tending to demonstrate that phenacetin is smuggled from a single source or similar ones. Consequently, stable isotopes could only be used to exclude that several samples come from a common source. Copyright © 2016 John Wiley & Sons, Ltd.
Topics: Analgesics, Non-Narcotic; Carbon Isotopes; Chromatography, Gas; Cocaine; Dopamine Uptake Inhibitors; Illicit Drugs; Mass Spectrometry; Phenacetin
PubMed: 27860349
DOI: 10.1002/dta.2137 -
Applied Therapeutics Jul 1970
Review
Topics: Age Factors; Animals; Body Weight; Cats; Circadian Rhythm; Diet; Dogs; Drug Tolerance; Guinea Pigs; Nutritional Physiological Phenomena; Phenacetin; Rats; Seasons; Sex Factors; Species Specificity
PubMed: 4920538
DOI: No ID Found -
Mutation Research Nov 1978
Topics: Genetic Techniques; Mutagens; Phenacetin; Salmonella typhimurium
PubMed: 370580
DOI: 10.1016/0165-1218(78)90031-9