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American Journal of Diseases of... Jan 1967
Topics: Adolescent; Adult; Anemia, Hemolytic; Female; Humans; Methemoglobinemia; Phenacetin; Phenobarbital
PubMed: 6015912
DOI: 10.1001/archpedi.1967.02090160131017 -
Annals of the New York Academy of... Jul 1968
Topics: Adolescent; Adult; Chromatography, Paper; Electrophoresis; Erythrocytes; Female; Glucosephosphate Dehydrogenase Deficiency; Glucuronates; Heinz Bodies; Hemolysis; Humans; Male; Methemoglobin; Methemoglobinemia; Middle Aged; Phenacetin; Phenobarbital
PubMed: 5263690
DOI: 10.1111/j.1749-6632.1968.tb48266.x -
Tandlaegebladet Apr 1974
Topics: Analgesics; Phenacetin
PubMed: 4532867
DOI: No ID Found -
Deutsche Medizinische Wochenschrift... Jan 1974
Topics: Asthma; Humans; Nephritis, Interstitial; Phenacetin
PubMed: 4812779
DOI: No ID Found -
Vrachebnoe Delo Mar 1968
Topics: Adult; Humans; Male; Phenacetin
PubMed: 5663847
DOI: No ID Found -
Deutsche Medizinische Wochenschrift... Jan 1978
Topics: Acetaminophen; Humans; Kidney Diseases; Methods; Phenacetin
PubMed: 624253
DOI: 10.1055/s-0028-1104387 -
L'Infirmiere Francaise Jun 1976
Topics: Aminopyrine; Phenacetin
PubMed: 1047035
DOI: No ID Found -
L'union Medicale Du Canada Oct 1970
Clinical Trial Comparative Study
Topics: Adolescent; Adult; Analgesics; Clinical Trials as Topic; Female; Humans; Kidney Papillary Necrosis; Phenacetin; Pregnancy; Puerperal Disorders
PubMed: 4927627
DOI: No ID Found -
Bulletin Der Schweizerischen Akademie... Apr 1958
Topics: Phenacetin
PubMed: 13536662
DOI: No ID Found -
Journal of Pharmacobio-dynamics Feb 1985The mechanisms of renal damage produced by sulfanilamide and phenacetin were studied. N-Hydroxyphenacetin, 4-hydroxylaminobenzenesulfonamide (4-HABSA) and p-aminophenol...
The mechanisms of renal damage produced by sulfanilamide and phenacetin were studied. N-Hydroxyphenacetin, 4-hydroxylaminobenzenesulfonamide (4-HABSA) and p-aminophenol were established to be nephrotoxic metabolites. As well as N-hydroxylase activity of sulfanilamide, that of phenacetin in kidney microsomes of rats was increased about 4 times by pretreatment with 3, 4, 5, 3', 4'-pentachlorobiphenyl (PenCB) which is a potent inducer of cytochrome P-448. Parallel to this enzyme induction, pretreatment with PenCB enhanced the nephrotoxicity of phenacetin and sulfanilamide in rats. On the other hand, the formation of p-aminophenol from phenacetin was also confirmed in rat kidney in vitro. These results suggested that 4-HABSA, N-hydroxyphenacetin and p-aminophenol formed in kidney play an important role in the renal damage produced by sulfanilamide and phenacetin.
Topics: Animals; Hydroxylation; Kidney; Kinetics; Male; Phenacetin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfanilamide; Sulfanilamides
PubMed: 4009405
DOI: 10.1248/bpb1978.8.95