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Medizinische Klinik Feb 1975
Review
Topics: Adult; Age Factors; Aged; Epidemiologic Methods; Female; Germany, West; Humans; Kidney; Kidney Diseases; Kidney Papillary Necrosis; Male; Middle Aged; Phenacetin; Prospective Studies; Sex Factors; Substance-Related Disorders; Time Factors; Urogenital Neoplasms
PubMed: 1091837
DOI: No ID Found -
The Journal of Pharmacology and... Oct 1976In a total of 22 studies in the anesthetized dog, the renal clearnace of phenacetin was measured over a range of plasma concentrations and at different urinary pH and...
In a total of 22 studies in the anesthetized dog, the renal clearnace of phenacetin was measured over a range of plasma concentrations and at different urinary pH and rates of urine flow. Phenacetin is reabsorbed by passive diffusion. The urine/plasma ratio is essentially unity under all conditions. As measured by ultraviolet-spectrophotometric and colorometric methods and by high-pressure liquid chromatography, a labile metabolite appears in urine and renal papilla which upon hydrolysis gives rise to falsely high values for phenacetin. Renal cortical and papillary concentrations were determined in six dogs during hydropenia or diuresis. All tissue/plasma concentration ratios for phenacetin were essentially unity. The results indicate that the papillary localization of the earliest lesions of analgesic nephropathy cannot be attributed to high phenacetin concentrations within the papilla. This is in contrast to acetaminophen, the major metabolite of phenacetin.
Topics: Animals; Biological Transport, Active; Blood Proteins; Dogs; Female; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Kidney; Kidney Tubules; Methemoglobin; Phenacetin; Protein Binding
PubMed: 10421
DOI: No ID Found -
Nederlands Tijdschrift Voor Geneeskunde Apr 1984
Topics: Humans; Legislation, Drug; Nephritis, Interstitial; Netherlands; Phenacetin
PubMed: 6717652
DOI: No ID Found -
Deutsche Medizinische Wochenschrift... Mar 1972
Topics: Analgesics; Humans; Legislation, Drug; Legislation, Pharmacy; Phenacetin; Substance-Related Disorders
PubMed: 5011498
DOI: No ID Found -
Naunyn-Schmiedeberg's Archives of... Nov 1978The fate of phenacetin and some of tis metabolites have been examined in isolated rat hepatocytes. The overall pattern of metabolism was similar to that found in vivo by...
The fate of phenacetin and some of tis metabolites have been examined in isolated rat hepatocytes. The overall pattern of metabolism was similar to that found in vivo by others. The major metabolites of phenacetin were paracetamol, free and conjugated, and phenetidine, and about 10% was lost. No N-hydroxyphenacetin was found, but experiments with N-hydroxyphenacetin as substrate showed that at low concentration (as might be formed from phenacetin) it disappeared very rapidly from cell suspensions. N-hydroxyphenacetin was metabolized to its conjugates, and to paracetamol, phenacetin and phenetidine, with a large proportion unaccounted for. With all substrates, increasing concentration resulted in a decreased percentage being metabolized, indicating that the metabolic pathways were saturable. Relatively more phenetidine was found at high phenacetin concentrations, however, apparently because phenetidine is an intermediate metabolite whose own elimination was slowed relatively more than its formation. N-hydroxylated arylamines were toxic to hepatocytes in a dose-dependent manner, suggesting that these cell suspensions could be used to test for hepatotoxicity.
Topics: Acetaminophen; Animals; Female; Hydroxylation; In Vitro Techniques; Liver; Phenacetin; Rats; Time Factors
PubMed: 732893
DOI: 10.1007/BF00508289 -
The Journal of Laboratory and Clinical... Dec 1978The metabolism of acetaminophen and phenacetin by rabbit kidney slices was investigated. Phenacetin, like aspirin, inhibited [131I] Hippuran accumulation by the organic...
The metabolism of acetaminophen and phenacetin by rabbit kidney slices was investigated. Phenacetin, like aspirin, inhibited [131I] Hippuran accumulation by the organic acid transport system. Phenacetin exhibited a dose-dependent inhibition with a K1 of 0.5 mM; acetaminophen at concentrations as high as 1 mM did not alter organic acid transport. [3H] acetaminophen slice: media ratios of approximately 1 or less suggested that acetaminophen entered cortex and outer and inner medullary slices by diffusion rather than active transport. Approximately 95% of the acetaminophen within the slices readily diffused out into the media. The chromatographic patterns of this material were similar to that of the incubation media. The acetaminophen remaining within the slices was acid-precipitable and not extractable with organic solvents. This covalent binding of acetaminophen was inhibited by glutathione. More acetaminophen was bound in the renal medullar than cortex. These data suggest that the renal metabolism of acetaminophen observed in this in vitro study may be related to the nephritis observed in analgesic abuse.
Topics: Acetaminophen; Animals; Biological Transport; Glutathione; Hippurates; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Phenacetin; Rabbits
PubMed: 739171
DOI: No ID Found -
Svenska Lakartidningen Oct 1957
Topics: Cause of Death; Cell Death; Drug-Related Side Effects and Adverse Reactions; Hemolysis; Humans; Phenacetin
PubMed: 13495894
DOI: No ID Found -
Report on Carcinogens : Carcinogen... 2011
Topics: Analgesics; Animals; Carcinogens; Humans; Neoplasms; Occupational Exposure; Phenacetin; Safety-Based Drug Withdrawals
PubMed: 21863078
DOI: No ID Found -
Lijecnicki Vjesnik May 1962
Topics: Humans; Kidney; Kidney Diseases; Phenacetin
PubMed: 13867859
DOI: No ID Found -
The Journal of Pharmacy and Pharmacology Feb 1971
Topics: Acetaminophen; Anilides; Chromatography, Gas; Indicators and Reagents; Methods; Phenacetin; Silicon
PubMed: 4396869
DOI: 10.1111/j.2042-7158.1971.tb08622.x