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The Journal of Pharmacy and Pharmacology Jun 1966
Topics: Acetaminophen; Aspirin; Caffeine; Erythrocytes; Female; Humans; Kidney; Kidney Tubules; Leukocytes; Male; Nephritis; Phenacetin
PubMed: 4381370
DOI: 10.1111/j.2042-7158.1966.tb07886.x -
Journal of Pharmaceutical Sciences Aug 1967
Topics: Aniline Compounds; Chromatography, Thin Layer; Drug Contamination; Phenacetin
PubMed: 6035327
DOI: 10.1002/jps.2600560822 -
Canadian Medical Association Journal Aug 1961
Topics: Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Humans; Nephritis; Nephritis, Interstitial; Phenacetin
PubMed: 13758378
DOI: No ID Found -
Pharmacology 1979N-hydroxyphenacetin glucuronide has been previously shown to be an unstable compound (half-life 8.7 h) that breaks down to phenacetin, 2-hydroxyphenacetin glucuronide,...
N-hydroxyphenacetin glucuronide has been previously shown to be an unstable compound (half-life 8.7 h) that breaks down to phenacetin, 2-hydroxyphenacetin glucuronide, acetaminophen, acetamide, and a deethylated metabolite that covalently binds to protein. Evidence was presented that the acetamide, acetaminophen and a compound that binds covalently were formed from a common intermediate which was postulated to be N-acetylimidoquinone. In the presence of phosphate buffer, 3-hydroxyphenacetin phosphate is formed at the expense of acetaminophen, acetamide and covalent binding. Phosphate buffer, however, only partially blocks covalent binding to protein suggesting that two deethylated reactive metabolites are formed that can covalently bind to protein. These metabolites also may be converted to acetaminophen but only one of them leads to acetamide. Since the phosphate conjugate contains the ethyl group apparently a third reactive intermediate, which can react with phosphate but not with protein, serves as a precursor of one of the metabolites.
Topics: Animals; Drug Stability; Glucuronates; Half-Life; Hydroxylation; In Vitro Techniques; Kinetics; Liver; Male; Phenacetin; Protein Binding; Rats
PubMed: 538078
DOI: 10.1159/000137318 -
The Journal of Clinical Investigation Nov 1969Since either aspirin or phenacetin might be causative in the nephropathy of analgesic abuse, studies were designed to examine the renal accumulation and distribution of...
Since either aspirin or phenacetin might be causative in the nephropathy of analgesic abuse, studies were designed to examine the renal accumulation and distribution of the major metabolic products of these compounds, salicylate and N-acetyl-p-aminophenol (APAP) respectively, in dogs. Nineteen hydropenic animals were studied, of which seven were given phenacetin, nine received acetyl salicylic acid, two were given both aspirin and phenacetin, and one received APAP directly. Two of three hydrated animals were given phenacetin and one was given aspirin. During peak blood levels of salicylate and (or) APAP, the kidneys were rapidly removed, frozen, sliced from cortex to papillary tip, and analyzed for water, urea, APAP, and salicylate. No renal medullary gradient for salicylate was demonstrable during both hydropenic and hydrated states. In contrast, both free and conjugated APAP concentrations rose sharply in the inner medulla during hydropenia, reaching a mean maximal value at the papillary tip exceeding 10 times the cortical concentration (P < 0.001), a distribution similar to that of urea. Salicylate had no effect on the APAP gradient, but hydration markedly reduced both the APAP and urea gradients in the medulla. The data indicate that APAP probably shares the same renal mechanisms of transport and accumulation as urea and acetamide, and that papillary necrosis from excessive phenacetin may be related to high papillary concentration of APAP.
Topics: Analgesics; Animals; Aspirin; Dehydration; Dogs; Female; Humans; Hydrogen-Ion Concentration; Kidney; Kidney Concentrating Ability; Kidney Diseases; Kidney Papillary Necrosis; Osmosis; Phenacetin; Salicylates; Substance-Related Disorders; Urea
PubMed: 5813230
DOI: 10.1172/JCI105932 -
Natural Product Communications Nov 2009Bursera grandifolia and other related species have been used in traditional herbal medicine in Mexico and other Latin American countries for their analgesic, antipyretic...
Bursera grandifolia and other related species have been used in traditional herbal medicine in Mexico and other Latin American countries for their analgesic, antipyretic and anti-inflammatory properties. From the chloroform extract of leaves of B. grandifolia, a substance was isolated and identified as phenacetin, a well known compound with widely tested analgesic and antipyretic properties. The structural identity of the compound was elucidated on the basis of chemical and spectroscopic evidence and by comparison with an authentic sample.
Topics: Analgesics, Non-Narcotic; Bursera; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Mexico; Phenacetin; Plant Leaves; Plant Preparations
PubMed: 19967994
DOI: No ID Found -
Clinical Toxicology Jun 1971
Topics: Administration, Oral; Anesthesia; Caffeine; Drug Antagonism; Drug Interactions; Hypothermia, Induced; Lethal Dose 50; Phenacetin; Thiopental; Time Factors; Urinary Bladder
PubMed: 5097489
DOI: 10.3109/15563657108990958 -
Science (New York, N.Y.) Dec 1976When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its...
When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.
Topics: Adult; Charcoal; Diet; Digestive System; Female; Humans; Liver; Male; Meat; Metabolic Clearance Rate; Phenacetin
PubMed: 982059
DOI: 10.1126/science.982059 -
The Journal of Urology May 1975
Topics: Aged; Carcinogens; Carcinoma, Transitional Cell; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Phenacetin; Substance-Related Disorders; Time Factors; Ureteral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms
PubMed: 1127809
DOI: 10.1016/s0022-5347(17)59546-4 -
The Journal of Pharmacy and Pharmacology Sep 1979
Topics: Animals; Aspirin; Drug Interactions; Female; Motor Activity; Phenacetin; Rats; Salicylates; Time Factors
PubMed: 41068
DOI: 10.1111/j.2042-7158.1979.tb13607.x