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The Journal of Pediatrics Dec 1980
Topics: Child, Preschool; Humans; Infant; Phencyclidine; Poisoning
PubMed: 7441408
DOI: 10.1016/s0022-3476(80)80447-1 -
Clinical Toxicology 1978
Topics: Adolescent; Adult; Anesthetics; Animals; Asphyxia; Drowning; Electroencephalography; Female; Haplorhini; Humans; Illicit Drugs; Male; Phencyclidine
PubMed: 95916
DOI: 10.3109/15563657809150017 -
Veterinary and Human Toxicology Apr 1979
Topics: Dose-Response Relationship, Drug; Humans; Illicit Drugs; Pharmaceutical Preparations; Phencyclidine; Time Factors
PubMed: 442469
DOI: No ID Found -
Journal of Toxicology. Clinical... Oct 1982Phencyclidine (PCP) concentrations have been studied in the blood and tissues of Los Angeles County victims whose deaths were related to PCP use. In most cases PCP blood...
Phencyclidine (PCP) concentrations have been studied in the blood and tissues of Los Angeles County victims whose deaths were related to PCP use. In most cases PCP blood concentrations ranged from 0.01 to 0.9 micrograms/mL while higher concentrations were found in the liver, urine, bile, brain, and kidney.
Topics: Adult; Autopsy; Bile; Brain Chemistry; Chromatography, Gas; Female; Humans; Kidney; Liver; Male; Phencyclidine; Racial Groups; Substance-Related Disorders; Toxicology
PubMed: 7182512
DOI: 10.3109/15563658208992517 -
NIDA Research Monograph 1986
Topics: Animals; Brain; Female; Humans; Maternal-Fetal Exchange; Motor Activity; Narcotics; Phencyclidine; Phencyclidine Abuse; Pregnancy; Psychoses, Substance-Induced; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereotyped Behavior; Structure-Activity Relationship; Synapses
PubMed: 3012344
DOI: No ID Found -
European Journal of Pharmacology Nov 1984A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs.... (Comparative Study)
Comparative Study
A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.
Topics: Animals; Catalepsy; Columbidae; Dose-Response Relationship, Drug; Humans; Ketamine; Pentobarbital; Phencyclidine; Stereoisomerism
PubMed: 6542865
DOI: 10.1016/0014-2999(84)90070-0 -
Methods in Molecular Biology (Clifton,... 2024Phencyclidine (PCP), a dissociative anesthetic, is a commonly abused recreational drug. In the 1950s, initially tested as an intravenous anesthetic, PCP was discontinued...
Phencyclidine (PCP), a dissociative anesthetic, is a commonly abused recreational drug. In the 1950s, initially tested as an intravenous anesthetic, PCP was discontinued for clinical use due to its severe adverse effects. Since then, it has gained popularity as a recreational drug due to its ability to induce hallucinations and alter perception. PCP can be detected in urine, serum, or plasma by immunoassays and quantified and its presence confirmed by gas or liquid chromatography-mass spectrometry. In the method described here, a deuterated internal standard is added to the sample and the drug is extracted under alkaline conditions. Analysis is conducted using gas chromatography-mass spectrometry (GC-MS). Selected ion monitoring is used for quantitation of PCP.
Topics: Humans; Phencyclidine; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Substance-Related Disorders; Illicit Drugs
PubMed: 38036841
DOI: 10.1007/978-1-0716-3541-4_37 -
The Journal of Pharmacology and... Jul 1991The dependence-producing properties of 10 days of chronic i.v. infusions of phencyclidine (PCP) and the relationship between PCP serum concentrations and behavioral...
The dependence-producing properties of 10 days of chronic i.v. infusions of phencyclidine (PCP) and the relationship between PCP serum concentrations and behavioral effects were studied in Sprague-Dawley rats. For dependence studies, rats were trained to respond for food under a fixed-ratio 30 schedule during half-hour response periods every 6 hr. After training, implantation of jugular catheters, and restabilization of behavior, the rats were infused with PCP.HCl at 3.2, 5.6, 10.0 or 17.8 mg/kg/day (n = 5 or 6 per dose). The two higher doses initially decreased response rates, but tolerance developed within 4 to 5 days. When PCP infusions were terminated, dose-dependent decreases in session response rate occurred in the three highest dose groups (P less than .05). Mild, overt signs of abstinence were observed only in the highest dose group. Response rates returned to base line within 2 to 3 days after stopping PCP infusions. PCP serum concentrations in rats infused with 10 mg of PCP.HCl/kg/day for 10 days were stable from hour 24 to day 10 (mean steady-state concentration (+/- S.D.) = 97 (+/- 20) ng of PCP/ml; n = 4). The average terminal elimination half-life after stopping infusions on day 10 was 4.6 hr. Comparison of the average response rates with the average serum concentrations showed that during the first 24 hr of infusions, the rate of responding for food decreased as PCP concentrations increased; however, once the animals became tolerant to PCP there was no relationship. In contrast, during the first 24 hr after stopping infusions, response rates decreased as serum concentrations decreased.
Topics: Animals; Body Weight; Conditioning, Operant; Dose-Response Relationship, Drug; Infusions, Intravenous; Male; Phencyclidine; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance-Related Disorders
PubMed: 2072296
DOI: No ID Found -
The Journal of Pharmacology and... Sep 1985Phencyclidine (PCP) disposition kinetics has been examined in dogs as a function of dose and after i.v. and p.o. administration. Intravenous doses ranged from a tracer...
Phencyclidine (PCP) disposition kinetics has been examined in dogs as a function of dose and after i.v. and p.o. administration. Intravenous doses ranged from a tracer quantity of [3H]PCP to 5 mg/kg of unlabeled PCP. The elimination half-life of intact PCP was relatively short with harmonic mean values of 2.7, 5.4 and 3.9 hr for the tracer, 1- and 5-mg/kg doses, respectively. In contrast, measurement of total radioactivity gave a much longer half-life (35-52 hr) suggesting slower metabolite elimination. The drug has a large apparent volume of distribution (weighted mean of 20 liters/kg) and a systemic clearance (which is primarily metabolic) that approaches estimates of liver blood flow in the dog. Renal clearance of intact PCP represents a small fraction of total clearance. Percentage of the [3H]PCP dose recovered as total radioactivity was 49% in urine and 12% in feces. Several metabolites of PCP were determined in urine and they account for about 30% of the dose with the aminopentanoic acid derivative being present in the greatest amount. One of the hydroxylated metabolites is present in cis- and trans-forms, with the latter predominating. Three animals received an i.v. dose of [3H] PCP and a p.o. dose of unlabeled PCP at the same time to determine absolute bioavailability. Approximately 25% of the dose is absorbed intact. The p.o. (intrinsic) clearance of PCP is about four times greater than systemic clearance suggesting a blood flow-dependence in clearance and substantial first-pass hepatic metabolism.
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Kinetics; Phencyclidine; Tritium
PubMed: 4032285
DOI: No ID Found -
Proceedings of the National Academy of... Sep 1979[3H]Phencyclidine binds to synaptic membranes from rat brain in a saturable, reversible, and selective fashion, with a dissociation constant Kd of 0.25 microM and a...
[3H]Phencyclidine binds to synaptic membranes from rat brain in a saturable, reversible, and selective fashion, with a dissociation constant Kd of 0.25 microM and a maximal binding capacity of 2.4 pmol/mg of membrane protein--i.e., 250 pmol/g of brain. The binding activity is concentrated in synaptosomal fractions, is higher in cerebral cortex and corpus striatum than in other parts of the rat brain, and is not detectable in the spinal cord. Only molecules of the phencyclidine series and ketamine are able to bind to the phencyclidine receptor. [3H]Phencyclidine bound to its receptor is not displaced by the classical neurotransmitters or neuromodulators. There is a good correlation between the apparent affinities of a series of phencyclidine analogs for the phencyclidine receptor and the pharacological activities of these analogs as measured by the rotarod assay.
Topics: Animals; Binding, Competitive; Brain; Brain Mapping; Hydrogen-Ion Concentration; Ions; Ketamine; Male; Motor Activity; Phencyclidine; Rats; Receptors, Drug; Synaptosomes; Temperature
PubMed: 41247
DOI: 10.1073/pnas.76.9.4678