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NIDA Research Monograph 1992
Review
Topics: Animals; Electrophysiology; Humans; Ligands; Molecular Conformation; Phencyclidine; Receptors, Phencyclidine; Stereoisomerism
PubMed: 1435987
DOI: No ID Found -
American Journal of Clinical Pathology Aug 1978The clinical manifestations of phencyclidine abuse may include bizarre neuropsychiatric symptoms, which may mimic the untoward reactions of a variety of illicit drugs....
The clinical manifestations of phencyclidine abuse may include bizarre neuropsychiatric symptoms, which may mimic the untoward reactions of a variety of illicit drugs. Specific diagnosis and therapy depend, primarily, upon consideration of this drug followed by its prompt and accurate identification. A rapid modified thin-layer chromatographic technic for the detection and differentiation of phencyclindine from other alkaloids and neutral drugs with similar Rf values in this system is presented.
Topics: Chromatography, Thin Layer; Emergencies; Phencyclidine; Toxicology
PubMed: 696688
DOI: 10.1093/ajcp/70.2.287 -
Journal of Psychopharmacology (Oxford,... Oct 2014Both acute and sub-chronic phencyclidine administration produce behavioural and pathophysiological changes that resemble some features of schizophrenia. The present...
Both acute and sub-chronic phencyclidine administration produce behavioural and pathophysiological changes that resemble some features of schizophrenia. The present study aimed to determine if acute and sub-chronic phencyclidine treatment in male rats produces deficits in sociability and social novelty preference, which may reflect aspects of the negative symptomatology observed in schizophrenia. Rats were treated with phencyclidine acutely (2 or 5 mg/kg) or subchronically (2 or 5 mg/kg bi-daily for one week followed by a one week wash-out period) or vehicle. Social affiliative behaviour was assessed using the sociability and preference for social novelty paradigm where social interaction time was measured in (a) a chamber containing an unfamiliar conspecific vs an empty chamber (sociability), or (b) a chamber containing an unfamiliar conspecific vs a chamber containing a familiar conspecific (preference for social novelty). Results showed that acute administration of phencyclidine produced a reduction in measures of sociability but had no effect on preference for social novelty while sub-chronic administration of phencyclidine had no effect on sociability or social novelty. This study provides further evidence for the usefulness of phencyclidine models in modelling the symptomatology of schizophrenia.
Topics: Animals; Choice Behavior; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Hallucinogens; Male; Phencyclidine; Rats; Schizophrenic Psychology; Social Behavior
PubMed: 25122039
DOI: 10.1177/0269881114544778 -
Journal of Analytical Toxicology 1980
Topics: Animals; Chromatography, Gas; Drug Contamination; Gas Chromatography-Mass Spectrometry; Illicit Drugs; Lethal Dose 50; Male; Mice; Pharmaceutical Preparations; Phencyclidine
PubMed: 7421145
DOI: 10.1093/jat/4.3.119 -
Methods in Molecular Biology (Clifton,... 2010Phencyclidine (PCP) is a cycloalkylamine and is classified as a dissociative anesthetic. In the 1950s, PCP was tested as an intravenous anesthetic but due to its severe...
Phencyclidine (PCP) is a cycloalkylamine and is classified as a dissociative anesthetic. In the 1950s, PCP was tested as an intravenous anesthetic but due to its severe side effects, it was withdrawn from the clinical use. Since then PCP has become an illegal street drug making its laboratory analysis forensically essential. PCP can be detected in urine, serum, or plasma by immunoassays and quantified by gas or liquid chromatography mass spectrometry. In the method described here, a deuterated internal standard is added to the sample and the drug is extracted under alkaline conditions. Analysis is conducted using gas chromatography mass spectrometry (GC-MS). Quantitation of PCP is done by comparing the responses of unknown samples to the standards using selected ion monitoring.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Phencyclidine; Reproducibility of Results
PubMed: 20077098
DOI: 10.1007/978-1-60761-459-3_45 -
Journal of Medicinal Chemistry Oct 1984Several N-allyl derivatives of 1-phenylcyclohexylamine (PCA) were prepared, and their pharmacology was briefly characterized. The mono- and diallyl derivatives had... (Comparative Study)
Comparative Study
Several N-allyl derivatives of 1-phenylcyclohexylamine (PCA) were prepared, and their pharmacology was briefly characterized. The mono- and diallyl derivatives had phencyclidine-like activities in mice but were less potent behaviorally than phencyclidine (PCP). None were PCP antagonists. In vitro these compounds were competitive inhibitors of butyrylcholinesterase (BChE) and protected against inhibition by DFP. In addition, these agents displaced tritiated N-methyl-4-piperidyl benzilate from mouse-brain homogenates and inhibited the effects of acetylcholine on isolated guinea pig ileum. None of these in vitro effects correlated with their PCP-like behavioral activity in vivo in mice.
Topics: Animals; Brain; Butyrylcholinesterase; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Drug Interactions; Guinea Pigs; Horses; Ileum; Isoflurophate; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscle Contraction; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Structure-Activity Relationship
PubMed: 6481761
DOI: 10.1021/jm00376a006 -
Bioorganic & Medicinal Chemistry Letters Apr 2011The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B...
The identification of structurally novel analogues of ketamine and phencyclidine (PCP), as NMDA receptor antagonists, with low to moderate potency at GluN2A and GluN2B receptors is discussed. In particular, some examples, such as compounds 6 and 10, shows decreased calculated lipophilicity, when compared to PCP, while retaining moderate activity. Moreover, the germinal aryl amino substituted lactam ring, as exemplified in compounds 7-10 and 11-13, constitutes a novel scaffold with potential application in the design of biologically active compounds.
Topics: Ketamine; Phencyclidine; Receptors, N-Methyl-D-Aspartate
PubMed: 21334205
DOI: 10.1016/j.bmcl.2011.02.009 -
Journal of Medicinal Chemistry Feb 1998Three phencyclidine (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized. Each...
Three phencyclidine (PCP) analogues possessing a highly rigid carbocyclic structure and an attached piperidine ring which is free to rotate were synthesized. Each analogue has a specific fixed orientation of the ammonium center of the piperidinium ring to the centrum of the phenyl ring. The binding affinities of the rigid analogues 1-piperidino-7,8-benzobicyclo[4.2.0]octene (14), 1-piperidinobenzobicyclo[2.2.1]heptene (16), and 1-piperidinobenzobicyclo[2.2.2]octene (13) for the PCP receptor ([3H]TCP) and th-receptor (NANM) were determined. The three analogues show low to no affinity for the PCP receptor but good affinity for the th-receptor and can be considered th-receptor selective ligands with PCP/th ratios of 13, 293, and 368, respectively. The binding affinities for the th-receptor are rationalized in terms of a model for the th-pharmacophore.
Topics: Animals; Brain; Crystallography, X-Ray; Indicators and Reagents; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Phencyclidine; Radioligand Assay; Rats; Receptors, Phencyclidine; Receptors, sigma; Structure-Activity Relationship; Sigma-1 Receptor
PubMed: 9484497
DOI: 10.1021/jm970059p -
Annals of Emergency Medicine May 1981Medical records of 107 consecutive patients with a diagnosis of phencyclidine (PCP) intoxication were reviewed and in 27 of these the diagnosis was confirmed by positive...
Medical records of 107 consecutive patients with a diagnosis of phencyclidine (PCP) intoxication were reviewed and in 27 of these the diagnosis was confirmed by positive urine assay. In the 27 confirmed cases, the most common abnormalities present on physical examination were mental/behavioral (89%) and nystagmus (85%). Elevations in blood pressure, temperature, and heart rate that were statistically significant when compared with an age-matched control group also were noted. Review of available medical records disclosed that 13 of these patients had been evaluated previously at our institution for PCP intoxication. Toxicological screening tests including blood alcohol level, hypnotic screen, and urine test for alkaloids, were performed on 11 patients and found positive in four. The most common serious medical complication requiring hospitalization was rhabdomyolysis which occurred on three patients, two of whom developed acute renal failure. This complication may occur more frequently than previously recognized and should be excluded in patients with PCP intoxication.
Topics: Adolescent; Adult; California; Female; Humans; Male; Phencyclidine; Phencyclidine Abuse
PubMed: 7224272
DOI: 10.1016/s0196-0644(81)80048-0 -
Schizophrenia Research Aug 2007
Topics: Animals; Brain-Derived Neurotrophic Factor; Drug Administration Schedule; Enzyme Inhibitors; Hippocampus; Phencyclidine; Rats
PubMed: 17560767
DOI: 10.1016/j.schres.2007.04.032