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Chemistry, An Asian Journal Apr 2020In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the...
In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the biointerface is of great significance for understanding life phenomena and treatment in vitro. In this paper, a chiral biointerface was constructed by the virtue of host-guest interaction between a water-soluble pillar[5]arene (WP5) and phenethylamine (PEA) over a gold surface for adsorption of lysozyme proteins. From the experimental results it was identified that the host-guest biointerface has a high adsorption capacity and strong chiral selectivity. Furthermotre, it was identified that the host-guest interaction plays the decisive role in the enhancement of chirality of the interface, which was much beneficial for increasing protein adsorption and amplifying the capacity of chiral discrimination. Therefore, this work provides a new idea for the construction of biointerface materials with high protein adsorption capacity and high chiral selectivity through supramolecular interaction, which will have potential applications in the fields of biosensors, biocatalysts, biomaterials.
Topics: Adsorption; Biocatalysis; Biocompatible Materials; Biosensing Techniques; Calixarenes; Gold; Muramidase; Phenethylamines; Proteins; Stereoisomerism
PubMed: 32073754
DOI: 10.1002/asia.201901821 -
Pharmacology, Biochemistry, and Behavior Jul 1986Mice receiving daily injections of phenylethylamine (PEA) exhibited an enhanced PEA-induced motor stimulation, beginning on day 21 of administration. The mice receiving...
Mice receiving daily injections of phenylethylamine (PEA) exhibited an enhanced PEA-induced motor stimulation, beginning on day 21 of administration. The mice receiving PEA were also more sensitive to the stimulatory effect of amphetamine and PCP. There was no change in brain or hepatic monoamine oxidase activity nor in hepatic mixed function oxidase after this treatment, indicating that altered metabolism was not a factor in the sensitization. Striatal dopamine receptors, labelled by spiroperidol, were increased after the long-term PEA, suggesting that the sensitization may be due to increased dopaminergic receptor activity.
Topics: Animals; Brain; Corpus Striatum; Generalization, Stimulus; Liver; Male; Mice; Mixed Function Oxygenases; Monoamine Oxidase; Motor Activity; Phenethylamines; Receptors, Dopamine
PubMed: 3749219
DOI: 10.1016/0091-3057(86)90242-x -
Arzneimittel-Forschung Jun 1974
Topics: Alkanes; Amphetamine; Animals; Brain; Injections, Intraperitoneal; Male; Phenethylamines; Rats; Stimulation, Chemical
PubMed: 4408309
DOI: No ID Found -
Psychiatry Research Nov 1984Urinary phenylethylamine (PEA) excretion was evaluated in two populations of depressed hospitalized patients. Seven of 53 patients had PEA values exceeding three times...
Urinary phenylethylamine (PEA) excretion was evaluated in two populations of depressed hospitalized patients. Seven of 53 patients had PEA values exceeding three times the highest value found in 16 normal controls. The patients with high PEA excretion were all females. They were not, however, otherwise clinically distinguishable from depressed patients with low PEA. In a subsample of 31 patients and 10 controls, PEA excretion was not correlated with phenylacetic acid (PAA) excretion. These results suggest that depression is not associated with a generalized PEA deficit and that PAA reductions, previously reported in a depressed patient population, may not reflect a PEA abnormality.
Topics: Adolescent; Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Aged; Phenethylamines; Phenylacetates
PubMed: 6597458
DOI: 10.1016/0165-1781(84)90034-9 -
Journal of Natural Products Jan 2020Schwarzinicines A-G (-), representing the first examples of 1,4-diarylbutanoid-phenethylamine conjugates, were isolated from the leaves of . The structures of these...
Schwarzinicines A-G (-), representing the first examples of 1,4-diarylbutanoid-phenethylamine conjugates, were isolated from the leaves of . The structures of these compounds were determined by detailed analysis of their MS, 1D and 2D NMR data. Compounds - exhibited pronounced vasorelaxant effects in the rat isolated aorta ( 106-120%; EC 0.96-2.10 μM). However, compounds and showed no cytotoxic effects against A549, MCF-7, and HCT 116 human cancer cells (IC > 10 μM).
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Ficus; HCT116 Cells; Humans; Molecular Structure; Phenethylamines; Plant Leaves; Rats
PubMed: 31935094
DOI: 10.1021/acs.jnatprod.9b01160 -
Journal of Chemical Ecology Nov 2021With carbon dioxide (CO) levels rising dramatically, climate change threatens marine environments. Due to increasing CO concentrations in the ocean, pH levels are...
With carbon dioxide (CO) levels rising dramatically, climate change threatens marine environments. Due to increasing CO concentrations in the ocean, pH levels are expected to drop by 0.4 units by the end of the century. There is an urgent need to understand the impact of ocean acidification on chemical-ecological processes. To date, the extent and mechanisms by which the decreasing ocean pH influences chemical communication are unclear. Combining behaviour assays with computational chemistry, we explore the function of the predator related cue 2-phenylethylamine (PEA) for hermit crabs (Pagurus bernhardus) in current and end-of-the-century oceanic pH. Living in intertidal environments, hermit crabs face large pH fluctuations in their current habitat in addition to climate-change related ocean acidification. We demonstrate that the dietary predator cue PEA for mammals and sea lampreys is an attractant for hermit crabs, with the potency of the cue increasing with decreasing pH levels. In order to explain this increased potency, we assess changes to PEA's conformational and charge-related properties as one potential mechanistic pathway. Using quantum chemical calculations validated by NMR spectroscopy, we characterise the different protonation states of PEA in water. We show how protonation of PEA could affect receptor-ligand binding, using a possible model receptor for PEA (human TAAR1). Investigating potential mechanisms of pH-dependent effects on olfactory perception of PEA and the respective behavioural response, our study advances the understanding of how ocean acidification interferes with the sense of smell and thereby might impact essential ecological interactions in marine ecosystems.
Topics: Animals; Anomura; Cues; Oceans and Seas; Olfactory Perception; Phenethylamines; Seawater
PubMed: 34014453
DOI: 10.1007/s10886-021-01276-9 -
Neurochemical Research Sep 2014Administration of β-phenylethylamine (PEA), the simplest endogenous neuroamine, and various methylated PEA derivatives including α-methyl PEA (amphetamine, AMP)...
Administration of β-phenylethylamine (PEA), the simplest endogenous neuroamine, and various methylated PEA derivatives including α-methyl PEA (amphetamine, AMP) elicits analgesia in mice. Five or 20 min after intraperitoneal PEA injection of as little as 6 mg/kg resulted in an increased latency response time (from 2.4 ± 0.4 to 8.5 ± 2.3 or 7.0 ± 3.0 s, respectively) to the thermal stimulus (hot-plate test), which reached statistical significance at the 15 mg/kg (20 min; 13.1 ± 0.4 s) or 25 mg/kg dose (5 min; 15.3 ± 4.1 s). This PEA effect, was dose-dependent (albeit non-linear: 6, 12, 15, 25, 50 and 100 mg/kg), reached the cut-off time of 45 s at the upper PEA dose (5 min), and it was consistently enhanced by pretreatment with the monoamine oxidase inhibitor pargyline (P). Methylated PEA derivatives (15 and 100 mg/kg dose) produced various degrees of analgesia (in decreasing order p-Me PEA > PEA > N,N-diMe PEA > N-Me PEA) which, likewise to PEA itself, were consistently increased by P and declined over time (mice tested 5, 20 and 60 min after amine injection); small but statistically significant o- and β-Me PEA antinociceptive effects (5 min) were observed only at the higher dose (in the presence of P for β-Me PEA). A small analgesic effect was observed after the administration of AMP (5 or 10 mg/kg) which failed, even after P, to reach statistically significance. Independent of the amine and concentration tested, individual compound's antinociceptive properties were reliably increased by P (exception of AMP), decreased by reserpine (R) or haloperidol (H), and remained essentially unchanged after naloxone (N) administration suggesting the involvement of catecholamines, but not opioid peptides, in their observed analgesic effects. Injection of P + N produced results similar to those seen after P alone. Under the experimental conditions described neither P, R, H or N had any effects by themselves. These findings suggest additional understanding of the mechanism of action responsible for the analgesic effects of these amines would be of interest, leading further to controlled studies on their alleged usefulness as weight reducing agents and sport performance enhancers.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Male; Methylation; Mice; Phenethylamines
PubMed: 24965531
DOI: 10.1007/s11064-014-1354-7 -
Neurochemical Research Sep 1993There has been considerable interest in recent years in possible neurochemical abnormalities in Tourette's Syndrome (TS). In studies combining neuropsychological and... (Review)
Review
There has been considerable interest in recent years in possible neurochemical abnormalities in Tourette's Syndrome (TS). In studies combining neuropsychological and neurochemical measurements, we have investigated the possible roles of trace amines in this disorder. Urinary levels of free beta-phenylethylamine (PEA) and plasma levels of its precursor amino acid phenylalanine were decreased in TS patients when compared to values in normal children. These urinary PEA levels in TS patients were inversely related to several scores from the Tourette's Syndrome Global Scale (TSGS). Further investigation of the group of subjects with low urinary PEA indicated that they also had low levels of MHPG, normetanephrine, 5-HT and m- and p-tyramine. Patients with low PEA were also compared on an extensive battery of neuropsychological measures and observed to perform significantly worse than TS patients with normal urinary PEA levels. Biochemical measurements also suggest a possible abnormality in tryptamine turnover in TS since urinary levels of indole-3-acetic acid (IAA; the acid metabolite of tryptamine) are significantly lower in TS patients than in normal controls.
Topics: Biogenic Amines; Humans; Molecular Structure; Phenethylamines; Tourette Syndrome; Tryptamines
PubMed: 8232722
DOI: 10.1007/BF00966752 -
The Alabama Journal of Medical Sciences Oct 1964
Topics: Animals; Behavior, Animal; Cats; Deamination; Hallucinogens; Lagomorpha; Liver; Mescaline; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxidation-Reduction; Phenethylamines; Psychopharmacology; Rabbits; Research; Toxicology
PubMed: 14230671
DOI: No ID Found -
Learning & Memory (Cold Spring Harbor,... Jan 2009Mice communicate through visual, vocal, and olfactory cues that influence innate, nonassociative behavior. We here report that exposure to a recently fear-conditioned...
Mice communicate through visual, vocal, and olfactory cues that influence innate, nonassociative behavior. We here report that exposure to a recently fear-conditioned familiar mouse impairs acquisition of conditioned fear and facilitates fear extinction, effects mimicked by both an olfactory chemosignal emitted by a recently fear-conditioned familiar mouse and by the putative stress-related anxiogenic pheromone beta-phenylethylamine (beta-PEA). Together, these findings suggest social modulation of higher-order cognitive processing through pheromone communication and support the concurrent excitor hypothesis of extinction learning.
Topics: Animals; Association Learning; Behavior, Animal; Extinction, Psychological; Fear; Mice; Motor Activity; Pain Threshold; Phenethylamines; Pheromones; Psychotropic Drugs; Smell
PubMed: 19117912
DOI: 10.1101/lm.1226009