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Chemphyschem : a European Journal of... Jul 2017A phenolphthalein-based colorimetric probe bearing a dinitrobenzene group is reported as a thiophenol (PhSH)-selective chemodosimeter. PhSH can react with chemodosimeter...
A phenolphthalein-based colorimetric probe bearing a dinitrobenzene group is reported as a thiophenol (PhSH)-selective chemodosimeter. PhSH can react with chemodosimeter 1 to afford phenolphthalein. The addition of PhSH to the aqueous solution of 1 followed by a change in pH of the resulting solution to basic induces a selective color change from colorless to pink. Furthermore, using PhSH and base as inputs and color change of 1 by naked eye as an output, leads to the construction of an AND logic gate.
Topics: Colorimetry; Hydrogen-Ion Concentration; Molecular Structure; Phenolphthalein; Phenols; Sulfhydryl Compounds
PubMed: 28185359
DOI: 10.1002/cphc.201601348 -
The Journal of Biological Chemistry Dec 1946
Topics: Biological Assay; Chromogenic Compounds; Enzymes; Glucuronates; Glucuronic Acid; Glucuronidase; Phenolphthalein
PubMed: 20276190
DOI: No ID Found -
British Medical Journal Dec 1954
Topics: Eating; Encephalitis; Humans; Phenolphthalein
PubMed: 13209151
DOI: 10.1136/bmj.2.4902.1461 -
Memory (Hove, England) Oct 2023Retrieval practice typically benefits learning in children, although little is known about the benefits of retrieval practice for learning spelling. We investigated this...
Retrieval practice typically benefits learning in children, although little is known about the benefits of retrieval practice for learning spelling. We investigated this issue in three experiments with fifth-grade children from a low-income area of Brazil. In the experiments, children first read a list of words (study), and after a short interval wrote down the studied words after hearing and rereading them (copy) or after only hearing them (retrieval practice). After an interval of 4 days, spelling performance was greater for words from the retrieval practice condition than for words from the copy condition, but only when immediate corrective feedback was provided (Experiment 3). The current findings, therefore, suggest that retrieval practice followed by corrective feedback is an effective strategy to improve spelling performance of fifth-grade children.
Topics: Humans; Child; Brazil; Dioctyl Sulfosuccinic Acid; Hearing; Language; Learning; Phenolphthalein
PubMed: 37605436
DOI: 10.1080/09658211.2023.2248420 -
Legal Medicine (Tokyo, Japan) Apr 2009Quantitative high performance liquid chromatography (HPLC) to detect semen was investigated in this study. Briefly, 1cm of a gauze thread with a seminal stain was soaked...
Quantitative high performance liquid chromatography (HPLC) to detect semen was investigated in this study. Briefly, 1cm of a gauze thread with a seminal stain was soaked in the reaction mixture (phenolphthalein diphosphate tetrasodium dissolved in acetate buffer) for 5-10 min, and the supernatant was analyzed by HPLC with a spectrophotometric detector. Phenolphthalein was liberated from the reagent in the presence of acid phosphatase, and the liberated phenolphthalein was detected objectively and was unaffected by blood contamination. Since liberation of phenolphthalein from the reagent occurred slightly in control negative samples, the cut-off value of the examination should be set at 1.0 microg/ml.
Topics: Acid Phosphatase; Blood; Chromatography, High Pressure Liquid; Forensic Medicine; Humans; Indicators and Reagents; Male; Phenolphthalein; Semen; Spectrophotometry
PubMed: 19342276
DOI: 10.1016/j.legalmed.2009.02.050 -
California Medicine Jul 1949
Topics: Phenolphthalein; Phenolphthaleins
PubMed: 18153469
DOI: No ID Found -
Ultrasonics Sonochemistry Jan 2001Aqueous phenolphthalein solution under sonication was investigated for use as a chemical dosimeter. The fading time of aqueous phenolphthalein solution under sonication...
Aqueous phenolphthalein solution under sonication was investigated for use as a chemical dosimeter. The fading time of aqueous phenolphthalein solution under sonication depended on the concentration of phenolphthalein and the pH values of solutions. The fading time was correlated to the ultrasonic intensity in a reaction vessel that is estimated on the basis of decomposition of porphyrin. The relation between the fading time and the ultrasonic intensity for different frequencies is expressed by a single curve. From these results, it is indicated that aqueous solutions of phenolphthalein is useful for simple quantification of ultrasonic intensity for practical use, and one can regard it as one of the ultrasonic intensity indicators.
Topics: Phenolphthalein; Porphyrins; Solutions; Ultrasonics; Water
PubMed: 11105317
DOI: 10.1016/s1350-4177(00)00024-9 -
Macromolecular Rapid Communications Jul 2013The copolymerization parameters of N-(isopropyl)acrylamide (1) and N-(2-hydroxy-5-(1-(4-hydroxyphenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)benzyl)acrylamide (2) are...
Color indicator for supramolecular polymer chemistry: phenolphthalein-containing thermo- and pH-sensitive N-(Isopropyl)acrylamide copolymers and β-cyclodextrin complexation.
The copolymerization parameters of N-(isopropyl)acrylamide (1) and N-(2-hydroxy-5-(1-(4-hydroxyphenyl)-3-oxo-1,3-dihydroisobenzofuran-1-yl)benzyl)acrylamide (2) are determined. For both monomers, the homoaddition proceeds slightly faster than the heteroaddition step; however, the polymer formation occurs in a statistic fashion. Copolymers of different compositions are prepared and the cloud points are determined. Thereby, a significant influence of the concentration of monomer 2 and the pH value is found. For the first time, the complexation of polymer attached phenolphthalein by β-cyclodextrins is shown. Furthermore, it is possible to achieve a decomplexation by the addition of suitable guest molecules. Both procedures can be followed with the naked eye.
Topics: Acrylamides; Color; Hydrogen-Ion Concentration; Indicators and Reagents; Phenolphthalein; Polymerization; Temperature; beta-Cyclodextrins
PubMed: 23712563
DOI: 10.1002/marc.201300292 -
Biochemistry Jun 2008The study of the mechanism of amyloid fibril formation and its inhibition is of key medical importance due to the lack of amyloid assembly inhibitors that are approved...
The study of the mechanism of amyloid fibril formation and its inhibition is of key medical importance due to the lack of amyloid assembly inhibitors that are approved for clinical use. We have previously demonstrated the potent inhibitory potential of phenolsulfonphthalein, a nontoxic compound that was approved for diagnostic use in human subjects, on aggregation of islet amyloid polypeptide (IAPP) that is associated with type 2 diabetes. Here, we extend our studies on the mechanism of action of phenolsulfonphthalein by comparing its antiamyloidogenic effect to a very similar compound that is also approved for human use, phenolphthalein. While these compounds have very similar primary chemical structures, they significantly differ in their three-dimensional conformation. Our results clearly demonstrated that these two compounds had completely different inhibitory potencies: While phenolsulfonphthalein was a very potent inhibitor of amyloid fibril formation by IAPP, phenolphthalein did not show significant antiamyloidogenic activity. This behavior was observed with a short amyloid fragment of IAPP and also with the full-length polypeptide. The NMR spectrum of IAPP 20-29 in the presence of phenolsulfonphthalein showed chemical shift deviations that were different from the unbound or phenolphthalein-bound peptide. Differential activity was also observed in the inhibition of insulin amyloid formation by these two compounds, and density-gradient experiments clearly demonstrated the different inhibitory effect of the two compounds on the formation of prefibrillar assemblies. Taken together, our studies suggest that the three-dimensional arrangement of the polyphenol phenolsulfonphthalein has a central role in its amyloid formation inhibition activity.
Topics: Amyloid; Amyloid beta-Peptides; Dose-Response Relationship, Drug; Humans; Islet Amyloid Polypeptide; Magnetic Resonance Spectroscopy; Phenolphthalein; Phenolsulfonphthalein
PubMed: 18457421
DOI: 10.1021/bi800043d -
Il Farmaco; Edizione Pratica Oct 1986
Topics: Phenolphthalein; Phenolphthaleins; Polarography
PubMed: 3792534
DOI: No ID Found