-
Minerva Medica Dec 1948
Topics: Humans; Phenolphthalein
PubMed: 18122406
DOI: No ID Found -
Ear, Nose, & Throat Journal Dec 2022Cosmetic rhinoplasties are complex surgical procedures that can present with serious complications requiring revision surgeries. Septal graft difficulties are common... (Review)
Review
Cosmetic rhinoplasties are complex surgical procedures that can present with serious complications requiring revision surgeries. Septal graft difficulties are common complications in rhinoplasties, requiring surgeon awareness of the potential future need for corrective surgery. Here, we report a case of multiple revision cosmetic rhinoplasties due to recurrent complications. Additionally, a review of the literature regarding cosmetic rhinoplasty complications and risk factors was performed.
Topics: Humans; Rhinoplasty; Reoperation; Dioctyl Sulfosuccinic Acid; Phenolphthalein; Risk Factors
PubMed: 36036419
DOI: 10.1177/01455613221123826 -
Pharmacoepidemiology and Drug Safety May 2015
Topics: China; Constipation; Drug-Related Side Effects and Adverse Reactions; Humans; Laxatives; Patient Education as Topic; Phenolphthalein; Surveys and Questionnaires
PubMed: 25906829
DOI: 10.1002/pds.3777 -
Journal of Cardiovascular Pharmacology Mar 2009Thrombin increases intracellular free Ca ([Ca]i) in human platelets by 2 mechanisms: internal mobilization and the influx of Ca via store-operated Ca entry (SOCE)....
Thrombin increases intracellular free Ca ([Ca]i) in human platelets by 2 mechanisms: internal mobilization and the influx of Ca via store-operated Ca entry (SOCE). 2-Aminoethoxydiphenyl borate (2-APB) is an inhibitor of SOCE. In search for nonboron analogues of 2-APB, we identified a well-known compound, phenolphthalein, structurally related to 2-APB. Many phenolphthalein analogues inhibited the ability of thrombin and thapsigargin (a specific activator of SOCE) to increase [Ca]i. Phenolphthalein has an IC50 approximately 10 microM to inhibit thrombin-induced [Ca]i elevation, its active analogues have a similar potency. Several phenolphthalein analogues also inhibited thrombin-induced intracellular Ca mobilization, which indicates action on inositol 1,4,5-trisphosphate receptors. We identified structural features among active and inactive phenolphthalein analogues that are responsible for the activity. Opening of the 5-membered lactone ring of phenolphthalein resulted in a total loss of activity. If the diphenyl rings possessed primary amine, dimethyl amine, or a cyano group, there was no activity. Modifications to the diphenyl groups that were tolerated include phosphate, sulfate, iodine, bromine, methyl, nitrite, and methoxy. Inhibition of thrombin-induced [Ca]i increase by phenolphthalein was not mediated by an increase in cyclic adenosine monophosphate because the inhibitor of cyclic adenosine monophosphate-dependent protein kinase A, 4-cyano-3-methylisoquinoline, did not affect the inhibitory action of phenolphthalein. The inhibitory effect of phenolphthalein was not mediated by an increase in NO/cyclic guanosine monophosphate (cGMP) because the inhibitors of NO-sensitive soluble guanylyl cyclase, methylene blue, and ODQ did not affect the inhibition. Phytohemagglutinin and thapsigargin-induced SOCE in Jurkat cells was also inhibited by phenolphthalein and 2-APB to the same extent as seen in platelets. Therefore, phenolphthalein and its derivatives structurally similar to 2-APB inhibit SOCE in platelets and other cells.
Topics: Blood Platelets; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Humans; Ion Transport; Jurkat Cells; Phenolphthalein; Structure-Activity Relationship; Thrombin
PubMed: 19247192
DOI: 10.1097/FJC.0b013e31819b5494 -
The Journal of Pediatrics Aug 1954
Topics: Humans; Phenolphthalein
PubMed: 13184391
DOI: 10.1016/s0022-3476(54)80139-9 -
The Journal of Pharmacy and Pharmacology Dec 1962
Topics: Colorimetry; Humans; Phenolphthalein; Phenolphthaleins
PubMed: 14012120
DOI: 10.1111/j.2042-7158.1962.tb10533.x -
Breast Cancer Research and Treatment 1987There is a structural similarity between phenolphthalein and the triphenylethylenes which are known to interact with the estrogen receptor of human breast tissue....
There is a structural similarity between phenolphthalein and the triphenylethylenes which are known to interact with the estrogen receptor of human breast tissue. Phenolphthalein (10 microM) competed with estrogen for binding to MCF-7 human breast cancer cells in tissue culture and induced the synthesis of the progesterone receptor. The antiestrogen 4-hydroxytamoxifen blocked progesterone receptor induction both by estradiol and by phenolphthalein. Both estradiol (0.1 nM) and phenolphthalein (10 microM) stimulated cell growth as measured by DNA and protein assays. This growth stimulation was blocked by 4-hydroxytamoxifen. Phenolphthalein glucuronide, the major phenolphthalein metabolite, did not inhibit estrogen binding, induce progesterone receptor synthesis, or stimulate MCF-7 cell growth in culture. Yellow phenolphthalein, an impure phenolphthalein preparation used in nonprescription laxative preparations, had similar properties to pure phenolphthalein. Physicians should be aware of the weak estrogenic action of phenolphthalein, especially when recommending laxatives for breast cancer patients with confirmed liver and mesenteric metastases.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Cells, Cultured; DNA; Estradiol Congeners; Glucuronates; Humans; Phenolphthalein; Phenolphthaleins; Receptors, Estrogen; Receptors, Progesterone; Structure-Activity Relationship
PubMed: 3620717
DOI: 10.1007/BF01807368 -
Journal of the National Cancer Institute Dec 2000
Topics: Adult; Aged; Case-Control Studies; Cathartics; Colorectal Neoplasms; Drug Administration Schedule; Female; Humans; Logistic Models; Male; Middle Aged; Neoplasms; Phenolphthalein; Risk; Risk Factors; United States
PubMed: 11106687
DOI: 10.1093/jnci/92.23.1943 -
Pediatric Hematology and Oncology 1993
Topics: Adolescent; Adult; Child; Diarrhea; Female; Humans; Male; Menorrhagia; Munchausen Syndrome; Munchausen Syndrome by Proxy; Phenolphthalein; Phenolphthaleins; Warfarin
PubMed: 8217534
DOI: 10.3109/08880019309029485 -
Skinmed 2018
Topics: Constipation; Drug-Related Side Effects and Adverse Reactions; History, 20th Century; Humans; Laxatives; Phenolphthalein
PubMed: 29551115
DOI: No ID Found