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Pain Practice : the Official Journal of... 2008The nonselective alpha-adrenergic antagonist, phenoxybenzamine, has been used in the treatment of neuropathic pain syndromes, specifically, complex regional pain...
The nonselective alpha-adrenergic antagonist, phenoxybenzamine, has been used in the treatment of neuropathic pain syndromes, specifically, complex regional pain syndrome (CRPS) types I and II. This agent has also previously been used in intravenous regional peripheral blocks for treatment of CRPS I; however, an intravenous preparation of phenoxybenzamine is not currently available in the U.S.A. In this case series, systemic administration was more appropriate for three of the four patients, as their syndromes had spread beyond the initial area of surgery or trauma. We report an apparent clinical benefit in three of the four patients following oral administration. We postulate that this may be due to the noncompetitive (irreversible) blockade of alpha(1)- and alpha(2)-adrenergic receptors. We further hypothesize that this blockade could reduce stimulation of an increased population of adrenergic receptors in hyperalgesic skin, blunt the stimulation by norepinephrine of alpha(2)-adrenergic receptors on macrophages, and ultimately reduce the release of proinflammatory cytokines from cellular elements.
Topics: Administration, Oral; Adult; Female; Humans; Middle Aged; Phenoxybenzamine; Reflex Sympathetic Dystrophy; Vasodilator Agents
PubMed: 18194348
DOI: 10.1111/j.1533-2500.2007.00170.x -
British Journal of Anaesthesia Apr 2001
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Feedback; Humans; Phenoxybenzamine; Pheochromocytoma
PubMed: 11573642
DOI: 10.1093/bja/86.4.594 -
British Medical Journal Feb 1969
Topics: Humans; Phenoxybenzamine; Pulmonary Edema; Shock
PubMed: 5764263
DOI: 10.1136/bmj.1.5642.507-a -
European Journal of Pharmacology Apr 1980
Topics: Animals; Binding Sites; Cerebral Cortex; Desipramine; Male; Phenoxybenzamine; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Time Factors
PubMed: 6245899
DOI: 10.1016/0014-2999(80)90104-1 -
Journal of Neurology, Neurosurgery, and... Feb 1986
Topics: Dose-Response Relationship, Drug; Humans; Middle Aged; Phenoxybenzamine; Tremor
PubMed: 3950649
DOI: 10.1136/jnnp.49.2.222-a -
The Journal of Pharmacology and... Feb 1972
Topics: Animals; Bretylium Compounds; Chromatography, Paper; Cocaine; Female; Glycols; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Norepinephrine; Pargyline; Phenoxybenzamine; Propranolol; Reserpine; Sympathomimetics; Time Factors; Tritium
PubMed: 5010675
DOI: No ID Found -
Bollettino Della Societa Italiana Di... Jul 1980Ergometrine is currently used as a test for Prinzmetal variant angina, causing specifically a coronary artery spasm in these patients, even if the mechanism of this drug...
Ergometrine is currently used as a test for Prinzmetal variant angina, causing specifically a coronary artery spasm in these patients, even if the mechanism of this drug on coronaries is still unclear. In isolated rabbit heart perfused at constant flow the administration of ergometrine at the concentration of 2.2 x 10(-5) M evoked a marked and longlasting increase of coronary resistance which was revealed by a rise in perfusion pressure from 68.2 +/- 12.9 to 124.4 +/- 21.7 (m +/- SD; n=21). This increase appears only with repeated perfusions of the drug and moreover it was not reproducible in the same preparation after its maximal response. The vasoconstriction was not significantly affected either by atropine or mepyramine, but it was strongly reduced by the phenoxybenzamine pretreatment (2.9 x 10(-6) M; n=8). It is evident the role of alpha-adrenergic receptors in ergometrine effect, but our results do not allow to understand its true mechanism, in fact the noradrenaline release can not be completely excluded.
Topics: Animals; Coronary Vessels; Ergonovine; Heart; Perfusion; Phenoxybenzamine; Rabbits; Vascular Resistance
PubMed: 7448041
DOI: No ID Found -
Nature Jan 1976
Topics: Animals; Anura; Heart; Phenoxybenzamine; Receptors, Adrenergic; Temperature
PubMed: 1250360
DOI: 10.1038/259251a0 -
Proceedings of the Society For... Dec 1971
Topics: Adrenergic alpha-Antagonists; Animals; Castration; Chorionic Gonadotropin; Estrus; Female; Luteinizing Hormone; Ovary; Ovulation; Phenoxybenzamine; Pregnancy; Propranolol; Rats; Sodium Chloride
PubMed: 4399816
DOI: 10.3181/00379727-138-36035 -
Yakugaku Zasshi : Journal of the... Dec 1980
Topics: Animals; Drug Interactions; Guanethidine; Guinea Pigs; In Vitro Techniques; Male; Methamphetamine; Phenoxybenzamine; Sympatholytics; Vas Deferens
PubMed: 7252781
DOI: 10.1248/yakushi1947.100.12_1247