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Lancet (London, England) Feb 1973
Topics: Adult; Animals; Female; Guinea Pigs; Humans; Injections, Intradermal; Male; Phenoxybenzamine; Skin; Skin Tests
PubMed: 4119191
DOI: 10.1016/s0140-6736(73)91561-4 -
The Journal of Physiology Mar 19741. The effects of low concentrations of phenoxybenzamine (8.8 x 10(-10) to 2.9 x 10(-7)M) on responses and on noradrenaline overflow elicited by nerve stimulation were...
Negative feed-back regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and post-synaptic adrenergic receptors.
1. The effects of low concentrations of phenoxybenzamine (8.8 x 10(-10) to 2.9 x 10(-7)M) on responses and on noradrenaline overflow elicited by nerve stimulation were studied in the perfused cat's spleen.2. In the presence of 8.8 x 10(-10)M or 2.9 x 10(-9)M phenoxybenzamine there was a significant reduction in responses to nerve stimulation while the overflow of the transmitter did not increase at the two frequencies of stimulation employed: 5 and 30 Hz.3. In the presence of 2.9 x 10(-8)M or 2.9 x 10(-7)M phenoxybenzamine the responses to nerve stimulation were practically abolished and a significant increase in transmitter overflow was obtained at both frequencies of stimulation. The drug was more effective in increasing transmitter overflow at 5 Hz when compared with 30 Hz.4. The higher effectiveness of phenoxybenzamine in blocking the post-synaptic alpha-receptor when compared with the blockade of the presynaptic alpha-receptor that regulates transmitter release is compatible with the view that these two receptors are not identical.5. A second alternative for the difference in effectiveness of phenoxybenzamine is that both types of alpha receptors are identical, but the spare receptor capacity for the presynaptic adrenergic receptors is higher than that of the post-synaptic receptors.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Feedback; Female; In Vitro Techniques; Male; Neurons; Norepinephrine; Perfusion; Phenoxybenzamine; Pressure; Receptors, Adrenergic; Spleen; Synaptic Transmission
PubMed: 4363457
DOI: 10.1113/jphysiol.1974.sp010495 -
Anesthesiology Jun 2004
Topics: Adult; Female; Humans; Hypotension; Infant, Newborn; Male; Phenoxybenzamine; Pheochromocytoma; Pregnancy; Prenatal Exposure Delayed Effects; Respiratory Distress Syndrome, Newborn; Time
PubMed: 15166586
DOI: 10.1097/00000542-200406000-00039 -
The Practitioner May 1958
Topics: Humans; Phenoxybenzamine; Sympatholytics
PubMed: 13554049
DOI: No ID Found -
Drug and Therapeutics Bulletin Feb 1983
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Male; Phenoxybenzamine; Prostatic Hyperplasia; Urinary Bladder Neck Obstruction; Urinary Bladder, Neurogenic
PubMed: 6187524
DOI: No ID Found -
The Journal of Pharmacy and Pharmacology Jun 1972
Topics: Animals; Dogs; Electric Stimulation; In Vitro Techniques; Mesenteric Arteries; Muscle Contraction; Norepinephrine; Phenoxybenzamine
PubMed: 4403829
DOI: 10.1111/j.2042-7158.1972.tb09035.x -
Lancet (London, England) Dec 1970
Topics: Animals; Heart; Hydrogen-Ion Concentration; Isotonic Solutions; Perfusion; Phenoxybenzamine; Potassium; Rats; Sodium Chloride; Temperature; Time Factors; Tissue Preservation
PubMed: 4098453
DOI: 10.1016/s0140-6736(70)90366-1 -
The British Journal of Surgery Oct 1977Thirty patients awaiting prostatectomy with no history of cardiovascular disease were selected for a trial of alpha-adrenergic blocking agents. Twenty-seven patients... (Clinical Trial)
Clinical Trial
Thirty patients awaiting prostatectomy with no history of cardiovascular disease were selected for a trial of alpha-adrenergic blocking agents. Twenty-seven patients completed the trial, 19 of them with unpleasant side effects. Eighteen of them found their symptoms were improved and 10 showed urodynamic improvement.
Topics: Chronic Disease; Clinical Trials as Topic; Humans; Male; Phenoxybenzamine; Prostatic Hyperplasia; Time Factors
PubMed: 72581
DOI: 10.1002/bjs.1800641019 -
Lancet (London, England) Dec 1974
Topics: Aged; Drug Antagonism; Humans; Hypertension; Infusions, Parenteral; Male; Phenoxybenzamine; Pheochromocytoma; Practolol; Syncope; Tachycardia
PubMed: 4140426
DOI: 10.1016/s0140-6736(74)90254-2 -
British Medical Journal (Clinical... Feb 1984
Topics: Female; Humans; Male; Morphine; Phenoxybenzamine; Urination Disorders
PubMed: 6421419
DOI: 10.1136/bmj.288.6417.645-c