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Lancet (London, England) Apr 1999
Topics: Blood Platelets; Humans; Monoamine Oxidase Inhibitors; Phentermine; Serotonin
PubMed: 10218558
DOI: 10.1016/S0140-6736(05)74358-0 -
Journal of Forensic Sciences Oct 1984A case is presented where phentermine, a sympathomimetic amine used as an anorectic drug, is believed to have significantly contributed to the death of an individual in...
A case is presented where phentermine, a sympathomimetic amine used as an anorectic drug, is believed to have significantly contributed to the death of an individual in whom other drugs were also found. Blood, urine, and tissue concentrations of phentermine are reported and compared to other cases in the literature.
Topics: Adult; Death; Forensic Medicine; Humans; Male; Phentermine; Tissue Distribution
PubMed: 6502120
DOI: No ID Found -
Journal of the American Pharmacists... 2015
Topics: Appetite Depressants; Female; Humans; Phentermine; Subarachnoid Hemorrhage
PubMed: 25616199
DOI: 10.1331/JAPhA.2015.14263 -
Nursing Feb 1997
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Gastrointestinal Diseases; Humans; Obesity; Phentermine
PubMed: 9171612
DOI: 10.1097/00152193-199702000-00027 -
Alcohol (Fayetteville, N.Y.) Jan 2000The drug combination of phentermine plus fenfluramine has been used clinically in both the treatment of obesity and alcoholism. The aim of the current study was to...
The drug combination of phentermine plus fenfluramine has been used clinically in both the treatment of obesity and alcoholism. The aim of the current study was to assess the interaction of the two drugs on consumption of both an alcohol-containing and a nonalcoholic diet. Furthermore, the efficacy of the drug combination on suppression of withdrawal seizures was determined. Animals were either maintained on a 6% alcohol-containing diet, free-fed an isocaloric control, or pair-fed the control diet. It was observed that, with regard to body weight growth curves, alcohol provides about 2.5 kcal/g. Both phentermine and fenfluramine caused a decrease in consumption 1 h after administration; however, during the next 23 h, 4 mg/kg phentermine significantly increased consumption of all diets. At doses of 1 and 2 mg/kg, fenfluramine selectively reduced consumption of the alcohol-containing diet as compared to the isocaloric diets. Lower doses of fenfluramine blocked the increases in consumption induced by phentermine. Furthermore, in animals fed the nonalcoholic diet, the drug combination of 2 mg/kg fenfluramine plus 8 mg/kg phentermine produced a 63-82% reduction in consumption, an effect not seen when either drug was administered alone. This greater than additive effect was also seen in the earlier time periods in animals pair-fed the control diet. Neurochemical analysis from these animals revealed that the alcohol-dependent animals displayed a significant reduction of DOPAC and 5-HIAA levels in the striatum, frontal cortex, and hypothalamus after a 9-h withdrawal period, further implicating the serotonergic and dopaminergic systems in mediation of withdrawal symptoms and alcohol craving. Finally, 8 mg/kg phentermine plus 8 mg/kg fenfluramine completely abolished alcohol withdrawal seizures, compared to a 78% rate in saline treated rats. In conclusion, the coadministration of phentermine plus fenfluramine produced a moderate reduction of alcohol consumption and was completely effective at reducing alcohol withdrawal seizures.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Animals; Appetite Depressants; Drug Interactions; Drug Therapy, Combination; Eating; Fenfluramine; Male; Phentermine; Rats; Rats, Long-Evans; Selective Serotonin Reuptake Inhibitors; Weight Gain
PubMed: 10680713
DOI: 10.1016/s0741-8329(99)00047-6 -
Medical Hypotheses 2007
Topics: Adrenergic Agents; Appetite Depressants; Cyclobutanes; Humans; Hypoglycemic Agents; Metformin; Phentermine; Steroids; Weight Gain
PubMed: 17008024
DOI: 10.1016/j.mehy.2006.07.032 -
Mayo Clinic Proceedings Nov 2018
Topics: Adult; Contraindications, Drug; Dopamine Uptake Inhibitors; Dopaminergic Neurons; False Positive Reactions; Female; Humans; Male; Methylphenidate; Middle Aged; Parkinson Disease; Phentermine; Tomography, Emission-Computed, Single-Photon
PubMed: 30392555
DOI: 10.1016/j.mayocp.2018.09.012 -
The New England Journal of Medicine Apr 1998
Topics: Adult; Appetite Depressants; Drug Therapy, Combination; Endomyocardial Fibrosis; Female; Fenfluramine; Heart Failure; Humans; Phentermine
PubMed: 9565497
DOI: 10.1056/NEJM199804303381816 -
The New England Journal of Medicine Dec 1997
Topics: Aortic Valve Insufficiency; Drug Combinations; Echocardiography, Doppler, Color; Female; Fenfluramine; Humans; Male; Mitral Valve Insufficiency; Phentermine
PubMed: 9411248
DOI: No ID Found -
The New England Journal of Medicine Dec 1997
Topics: Fenfluramine; Heart Valve Diseases; Humans; Phentermine; Ultrasonography
PubMed: 9411246
DOI: 10.1056/NEJM199712113372414