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The New England Journal of Medicine Feb 1984
Topics: Humans; Phenylpropanolamine
PubMed: 6690977
DOI: 10.1056/NEJM198402093100621 -
The American Journal of Clinical... Jan 1992The use of phenylpropanolamine (PPA) as an anorectic has provoked commentary and disagreement. Its use in the last decade has been associated with a series of adverse... (Review)
Review
The use of phenylpropanolamine (PPA) as an anorectic has provoked commentary and disagreement. Its use in the last decade has been associated with a series of adverse clinical events. As in all case reports, these associations may be noncausal, particularly in light of PPAs extensive use. We have reviewed prospective clinical trials in which the administration of PPA was planned to assess impact on blood pressure. Many of these employ sedentary, healthy volunteers but also included are studies of overweight, moderately hypertensive, and ambulatory subjects. An analysis of such studies leads us to believe that PPA is an appropriately marketed over-the-counter drug, with an acceptable margin of safety. Further, we have reanalyzed our own earlier published data, which indicate that the margin of safety may actually be increased in subjects with elevated basal sympathetic tone; eg, those who are overweight and those with slight elevations of arterial blood pressure.
Topics: Appetite Depressants; Blood Pressure; Female; Humans; Hypertension; Male; Phenylpropanolamine; Prospective Studies
PubMed: 1728835
DOI: 10.1093/ajcn/55.1.206s -
American Family Physician Apr 1989Phenylpropanolamine is a sympathomimetic agent present in over 100 proprietary and prescription anorectics, nasal decongestants, psychostimulants and treatments for... (Review)
Review
Phenylpropanolamine is a sympathomimetic agent present in over 100 proprietary and prescription anorectics, nasal decongestants, psychostimulants and treatments for premenstrual syndrome. It is often found in street drugs prepared to look like amphetamines. Phenylpropanolamine has precipitated paranoid psychosis, severe anxiety, cerebrovascular accidents and hypertensive crises. Hypertensive crises can be treated with phentolamine. Psychiatric symptoms and anxiety are managed with benzodiazepines.
Topics: Humans; Hypertension; Mental Disorders; Phenylpropanolamine
PubMed: 2650503
DOI: No ID Found -
Lancet (London, England)
Topics: Brain; Cerebral Hemorrhage; Humans; Phenylpropanolamine
PubMed: 6140596
DOI: 10.1016/s0140-6736(83)90853-x -
Hypertension (Dallas, Tex. : 1979) Mar 1988Phenylpropanolamine is a sympathomimetic amine that shares structural similarities with amphetamine and ephedrine. It increases blood pressure primarily by increasing... (Review)
Review
Phenylpropanolamine is a sympathomimetic amine that shares structural similarities with amphetamine and ephedrine. It increases blood pressure primarily by increasing peripheral vascular resistance. This effect is the result of alpha-adrenergic agonist activity largely from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. As such, it has the potential to interact with other drugs to produce toxic reactions, especially in treated hypertensive patients. Complications have occurred with single oral doses that suggest some normal subjects may be more sensitive to the drug than others. The incidence of serious complications in the general population is small but could be much higher in susceptible individuals (e.g., cardiomyopathic and hypertensive patients). The availability of high-dose phenylpropanolamine-containing preparations without medical supervision is potentially dangerous, and certain restrictions should be imposed on such preparations.
Topics: Chemical Phenomena; Chemistry; Humans; Hypertension; Nonprescription Drugs; Phenylpropanolamine; Structure-Activity Relationship
PubMed: 3280497
DOI: 10.1161/01.hyp.11.3_pt_2.ii7 -
Neurology Apr 1986
Topics: Adult; Female; Humans; Ischemic Attack, Transient; Phenylpropanolamine
PubMed: 3960341
DOI: 10.1212/wnl.36.4.593 -
American Family Physician Feb 1990
Topics: Drug Interactions; Humans; Nonprescription Drugs; Phenylpropanolamine; Research
PubMed: 2301204
DOI: No ID Found -
American Family Physician Oct 1986
Comparative Study
Topics: Amphetamines; Emotions; Humans; Phenylpropanolamine; Substance-Related Disorders
PubMed: 3766360
DOI: No ID Found -
American Family Physician Jun 1983
Topics: Appetite Depressants; Central Nervous System; Humans; Obesity; Phenylpropanolamine
PubMed: 6858818
DOI: No ID Found -
The New England Journal of Medicine Apr 2001
Topics: Appetite Depressants; Cerebral Hemorrhage; Drug Approval; Female; Humans; Male; Nasal Decongestants; Phenylpropanolamine; Risk Factors; Sex Factors; Substance-Related Disorders; United States; United States Food and Drug Administration
PubMed: 11291666
DOI: 10.1056/NEJM200104053441411