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Revista Da Escola de Enfermagem Da U S P 2021To assess the effect of Chahuang ointment, a Chinese herbal ointment, on the prevention of phlebitis in patients with peripherally inserted central catheters. (Randomized Controlled Trial)
Randomized Controlled Trial
OBJECTIVE
To assess the effect of Chahuang ointment, a Chinese herbal ointment, on the prevention of phlebitis in patients with peripherally inserted central catheters.
METHOD
This was a multicenter randomized controlled trial, with 171 eligible patients randomly assigned into one of three groups: the Chahuang ointment group, the Mucopolysaccharide Polysulfate cream group, and the control group. The degrees of vein injuries at 72 hours after peripherally inserted central catheter insertion were the primary outcome. Secondary outcomes were the vascular wall thickness, tissue edema and microthrombus evaluated by Color Doppler Flow Imaging, the vascular endothelial growth factor, and endothelin-1 (ET-1) expression in vivo.
RESULTS
Compared with the control group, the Chahuang ointment group showed significantly lower incidence of postoperative phlebitis, tissue edema, and microthrombus at 72 hours after peripherally inserted central catheter insertion (all P<0.01). The VEGF and ET-1 expression were significantly inhibited in the Chahuang ointment group after 3 days of treatment (both P<0.01). There were no statistical differences in the degree of vein injuries, microthrombus, or tissue edema between the Chahuang ointment and mucopolysaccharide polysulfate groups (all P>0.05).
CONCLUSION
Chahuang ointment was shown to provide effective prevention and protection against phlebitis after peripherally inserted central catheter insertion.
Topics: Catheterization, Central Venous; Catheterization, Peripheral; Catheters; Central Venous Catheters; Humans; Ointments; Phlebitis; Vascular Endothelial Growth Factor A
PubMed: 33729323
DOI: 10.1590/S1980-220X2019008003680 -
Bulletin Medical Nov 1951
Topics: Phlebitis; Venous Thrombosis
PubMed: 14896280
DOI: No ID Found -
Phlebologie 1977
Topics: Adult; Humans; Leg; Male; Middle Aged; Phlebitis; Varicose Veins
PubMed: 866434
DOI: No ID Found -
Journal of Clinical Nursing Jul 2020To evaluate the effectiveness of topical interventions in the prevention or treatment of intravenous therapy-related phlebitis.
AIMS AND OBJECTIVES
To evaluate the effectiveness of topical interventions in the prevention or treatment of intravenous therapy-related phlebitis.
BACKGROUND
Phlebitis is a severe inflammatory reaction that can be caused by intravenous therapy with hyperosmolar drugs. Although a variety of interventions are performed in several different countries, the most efficient method is yet to be established.
DESIGN
A systematic review of randomised controlled trials (RCTs) was conducted.
METHODS
Following the PRISMA checklist, we conducted a literature search using seven different databases using an individual strategy adapted for each. Studies in which any topical intervention was applied to prevent or treat intravenous therapy-related phlebitis which were published between 1998 and 2019 were analysed.
RESULTS
Data were collected of 13 RCTs, which in total collected data from 2,015 patients during hospital treatments with different types of intravenous therapies, such as fluid replacement, antibiotics, chemotherapy and antiarrhythmic drugs. The effectiveness of different topical interventions such as the application of nonsteroidal anti-inflammatory drugs, Sesame indicum oil, heparin sodium formulations, Chamomilla recutita tea and ointment, and Rosmarinus officinalis ointment were identified.
RELEVANCE TO CLINICAL PRACTICE
Although the studies suggest a potential to use phytotherapy agents as topical interventions, pharmaceutical preparations, main substrate, and pharmaceutical or phytotherapeutic origins are very different between studies. There are insufficient data to build a solid conclusion that lead us to recommend a specific topical intervention in the prevention or treatment of intravenous therapy-related phlebitis.
Topics: Administration, Intravenous; Administration, Topical; Humans; Phlebitis; Randomized Controlled Trials as Topic
PubMed: 32324314
DOI: 10.1111/jocn.15266 -
Not in the Same Vein: Inflammatory Bowel Disease, Malignancy, and Enterocolic Lymphocytic Phlebitis.Digestive Diseases and Sciences Feb 2021
Topics: Aged; Enterocolitis; Humans; Inflammatory Bowel Diseases; Lymphocytes; Male; Phlebitis
PubMed: 32594463
DOI: 10.1007/s10620-020-06425-w -
The Journal of Toxicological Sciences May 1999This study aims to determine the pH that peripheral veins can tolerate. Intravenous nutrient solutions with different pHs (from 4.52 to 6.71) were infused into rabbit...
This study aims to determine the pH that peripheral veins can tolerate. Intravenous nutrient solutions with different pHs (from 4.52 to 6.71) were infused into rabbit ear veins, and the veins were examined histopathologically. After 6-hr infusion at 10 mL/kg/hr, a commercial 2.72% amino acid/7.5% glucose solution with electrolytes (AG) caused obvious phlebitic changes, such as loss of venous endothelial cells, inflammatory cell infiltration, and perivascular edema, in all 6 rabbits because of its low pH (4.52) and high titratable acidity (22 mEq/L). The phlebitis was reduced when the solution was neutralized with NaOH to pH 5.93, and was almost eliminated when the pH was neutralized to 6.49. After 8-hr infusion at 15 mL/kg/hr, AG-adjusted pH to 6.30 caused slight phlebitic changes, but AG-adjusted pH to 6.71 scarcely caused any change. Furthermore, 24-hr infusion of the pH 6.49 solution caused no histopathological changes in 3 rabbits. These results suggest that the tolerance pH for the peripheral vein is about 6.5, and that an infusion solution does not cause phlebitis due to acidity if the pH is not lower than the tolerance pH.
Topics: Animals; Ear, External; Hydrogen-Ion Concentration; Infusions, Intravenous; Male; Phlebitis; Rabbits; Veins
PubMed: 10349613
DOI: 10.2131/jts.24.113 -
BMJ Case Reports Dec 2022A man in his 40s presented with a 7-day history of fever and abdominal pain after polypectomy of the sigmoid colon. On physical examination, he had mild tenderness on...
A man in his 40s presented with a 7-day history of fever and abdominal pain after polypectomy of the sigmoid colon. On physical examination, he had mild tenderness on deep palpation of the left lower abdominal quadrants without guarding, rigidity or rebound tenderness. Contrast-enhanced CT revealed the thrombosis of the inferior mesenteric vein and the portal vein. Blood cultures were positive for We diagnosed him with pylephlebitis after colonic polypectomy, as a rare complication. He was started on cefmetazole and heparin. Antibiotic and anticoagulation therapy were initiated. He had a complete recovery within 17 days. The patient had no evidence of underlying hypercoagulable condition, and no signs of recurrence at a 3-month follow-up. Pylephlebitis after colonic polypectomy is extremely rare. Although bacteraemia after colonoscopy was a rare complication, phlebitis should be considered in the differential diagnosis of patients who present with persisted fever and abdominal pain after polypectomy.
Topics: Male; Humans; Colon, Sigmoid; Phlebitis; Mesenteric Veins; Portal Vein; Abdominal Pain
PubMed: 36524262
DOI: 10.1136/bcr-2022-253095 -
Bulletin of the Parenteral Drug... 1977
Topics: Humans; Infusions, Parenteral; Personnel, Hospital; Phlebitis
PubMed: 597648
DOI: No ID Found -
BMJ Case Reports Aug 2012An 83-year-old woman presented to us with a 4-week history of general malaise, subjective fever and lower abdominal pain. Despite the intravenous infusion of...
An 83-year-old woman presented to us with a 4-week history of general malaise, subjective fever and lower abdominal pain. Despite the intravenous infusion of antibiotics, her blood results and physical condition worsened, resulting in her sudden death. Autopsy study revealed that the medium-sized veins of the mesentery were infiltrated by eosinophil granulocytes, lymphocytes, macrophages and multinucleated giant cells; however, the arteries were not involved. Microscopically, venous giant cell infiltration was observed in the gastrointestinal tract, bladder, retroperitoneal tissues and myocardium. The final diagnosis was giant cell phlebitis, a rare disease of unknown aetiology. This case demonstrates for the first time that giant cell phlebitis involving extra-abdominal organs, including hearts, can cause serious morbidity.
Topics: Abdominal Pain; Aged, 80 and over; Anti-Bacterial Agents; Autopsy; Ceftriaxone; Death, Sudden; Fatal Outcome; Female; Fever; Fluid Therapy; Giant Cells; Humans; Phlebitis
PubMed: 22859384
DOI: 10.1136/bcr-2012-006914 -
The British Journal of Ophthalmology Sep 1972
Topics: Adult; Diagnosis, Differential; Female; Fluorescein Angiography; Fundus Oculi; Humans; Male; Middle Aged; Ophthalmoscopy; Papilledema; Phlebitis; Prednisolone; Retinal Vein; Visual Acuity
PubMed: 4653856
DOI: 10.1136/bjo.56.9.652