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Organic Letters Nov 2023A visible-light mediated deoxygenative radical addition of carboxylic acids to dehydroalanines has been disclosed. The method can be used in β-acyl alanine derivative...
A visible-light mediated deoxygenative radical addition of carboxylic acids to dehydroalanines has been disclosed. The method can be used in β-acyl alanine derivative synthesis, including those chiral and deuterated variants, and late-stage peptide modification with various functional groups, both in the homogeneous phase and on the resin in SPPS. It provides a new tool kit for rapid construction of bioactive peptide analogues, which has been demonstrated by modification of the antimicrobial peptide Feleucin-K3.
Topics: Alanine; Carboxylic Acids; Peptides; Photochemistry
PubMed: 37966281
DOI: 10.1021/acs.orglett.3c03453 -
Photochemical & Photobiological... Jun 2012
Topics: History, 20th Century; History, 21st Century; Photochemistry; Phytochrome; Research
PubMed: 22588701
DOI: 10.1039/c2pp90018a -
Nature Chemistry Jan 2016
Topics: Biomimetics; Nanostructures; Organoplatinum Compounds; Photochemistry
PubMed: 26673256
DOI: 10.1038/nchem.2423 -
Chemical Reviews Jun 2007
Review
Topics: Catalysis; Environmental Pollution; Organic Chemicals; Photochemistry
PubMed: 17530909
DOI: 10.1021/cr068352x -
Occupational Health & Safety (Waco,... May 2005
Review
Topics: Animals; Chemistry Techniques, Analytical; Dogs; Environmental Monitoring; Equipment Design; Fires; Firesetting Behavior; Humans; Photochemistry
PubMed: 15986904
DOI: No ID Found -
Postepy Biochemii 1958
Topics: Nucleic Acids; Photochemistry
PubMed: 13601384
DOI: No ID Found -
Annual Review of Physical Chemistry 2005Electron injection at dye-sensitized semiconductors is reviewed. Particular emphasis is placed on theoretical and photoelectrochemical studies of dye-sensitized planar... (Review)
Review
Electron injection at dye-sensitized semiconductors is reviewed. Particular emphasis is placed on theoretical and photoelectrochemical studies of dye-sensitized planar and single-crystal electrodes. The accepted mechanism of electron injection, which was derived from these classical studies, is introduced. Selected photoelectrochemical studies of dye-sensitized nanocrystalline semiconductors are reviewed; emphasis is given to factors that influence the efficiencies of electron injection and charge recombination. The development of quasi-solid-state nanocrystalline dye-sensitized solar cells is also discussed. Recent time-resolved spectroscopic studies of electron injection and charge recombination are reviewed. These studies have led to a better understanding of electron injection mechanisms, and have revealed the limitations of the classical models.
Topics: Coloring Agents; Electrochemistry; Electrodes; Electrons; Injections; Nanotechnology; Photochemistry; Ruthenium Compounds; Semiconductors; Spectrophotometry
PubMed: 15796698
DOI: 10.1146/annurev.physchem.56.092503.141142 -
Advances in Biochemical... 2005Progress made in lab-scale applications of various coenzyme regeneration systems over the last two decades has mainly focused on the applications of NAD+/NADH- and... (Review)
Review
Progress made in lab-scale applications of various coenzyme regeneration systems over the last two decades has mainly focused on the applications of NAD+/NADH- and NADP+/NADPH-dependent oxidoreductase reactions. In situ regeneration systems for these reactions, as well as whole cell, enzymatic, electro-enzymatic, chemical, and photochemical reactions are presented, including details about their efficiency and novelty. The progress of enzyme reaction engineering is also reported.
Topics: Bioreactors; Biotechnology; Coenzymes; Electrochemistry; Enzyme Reactivators; Photochemistry; Pilot Projects
PubMed: 15791939
DOI: 10.1007/b98911 -
Combinatorial Chemistry & High... Jun 2005The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound... (Review)
Review
The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this 'analytical bottleneck' Geysen, in 1996 elaborated Merrifield's initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.
Topics: Chemistry Techniques, Analytical; Chromatography, Liquid; Mass Spectrometry; Photochemistry; Resins, Synthetic
PubMed: 16101013
DOI: 10.2174/1386207054020804 -
Journal of Peptide Science : An... Jul 2017The synthesis of peptide-based photocatalysts that use 1-N,N-dimethylaminopyrene as chromophore and their application in photocatalysis is reported. The...
The synthesis of peptide-based photocatalysts that use 1-N,N-dimethylaminopyrene as chromophore and their application in photocatalysis is reported. The copper(I)-catalyzed alkyne-azide cycloaddition was applied as key step to prepare the peptide-pyrene conjugates in quantitative yields for different short peptide sequences. The photocatalysts were evaluated for the nucleophilic addition of methanol to 1,1-diphenylethylenes to products with Markovnikov-type orientation The short peptides contain arginine as substrate binding site during photocatalysis, and thus, the reaction was performed without the additive triethylamine that was previously applied as electron shuttle. Full conversion of the substrate and good yields for the addition product were achieved. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
Topics: Catalysis; Peptides; Photochemistry; Pyrenes
PubMed: 28139060
DOI: 10.1002/psc.2966