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Clinics in Dermatology 1997
Review
Topics: Clinical Trials as Topic; Humans; PUVA Therapy; Photochemotherapy; Prognosis; Psoriasis
PubMed: 9313975
DOI: 10.1016/s0738-081x(97)00015-1 -
Advanced Healthcare Materials Apr 2018Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the... (Review)
Review
Photothermal therapy (PTT) and photodynamic therapy (PDT) both utilize light to induce a therapeutic effect. These therapies are rapidly gaining importance due to the noninvasiveness of light and the limited adverse effect associated with these treatments. However, most preclinical studies show that complete elimination of tumors is rarely observed. Combining PDT and PTT with chemotherapy or radiotherapy can improve the therapeutic outcome and simultaneously decrease side effects of these conventional treatments. Nanocarriers can help to facilitate such a combined treatment. Here, the most recent advancements in the field of photochemotherapy and photoradiotherapy, in which nanocarriers are employed, are reviewed.
Topics: Chemoradiotherapy; Drug Carriers; Humans; Hyperthermia, Induced; Nanostructures; Neoplasms; Photochemotherapy
PubMed: 29282903
DOI: 10.1002/adhm.201701211 -
CA: a Cancer Journal For Clinicians 2011Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The... (Review)
Review
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.
Topics: Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents
PubMed: 21617154
DOI: 10.3322/caac.20114 -
Biomedicine & Pharmacotherapy =... Oct 2018Photodynamic therapy (PDT) is a modern and non-invasive form of therapy, used in the treatment of non-oncological diseases as well as cancers of various types and... (Review)
Review
Photodynamic therapy (PDT) is a modern and non-invasive form of therapy, used in the treatment of non-oncological diseases as well as cancers of various types and locations. It is based on the local or systemic application of a photosensitive compound - the photosensitizer, which is accumulated in pathological tissues. The photosensitizer molecules absorb the light of the appropriate wavelength, initiating the activation processes leading to the selective destruction of the inappropriate cells. The photocytotoxic reactions occur only within the pathological tissues, in the area of photosensitizer distribution, enabling selective destruction. Over the last decade, a significant acceleration in the development of nanotechnology has been observed. The combination of photosensitizers with nanomaterials can improve the photodynamic therapy efficiency and eliminate its side effects as well. The use of nanoparticles enables achievement a targeted method which is focused on specific receptors, and, as a result, increases the selectivity of the photodynamic therapy. The object of this review is the anticancer application of PDT, its advantages and possible modifications to potentiate its effects.
Topics: Animals; Drug Carriers; Drug Delivery Systems; Electrochemotherapy; Humans; Nanomedicine; Nanoparticles; Neoplasms; Photochemotherapy; Photosensitizing Agents
PubMed: 30119176
DOI: 10.1016/j.biopha.2018.07.049 -
International Journal of Molecular... Oct 2022Clay-based bio-inorganic nanohybrids, such as layered double hydroxides (LDH), have been extensively researched in the various fields of biomedicine, particularly for... (Review)
Review
Clay-based bio-inorganic nanohybrids, such as layered double hydroxides (LDH), have been extensively researched in the various fields of biomedicine, particularly for drug delivery and bio-imaging applications. Recent trends indicate that such two-dimensional LDH can be hybridized with a variety of photo-active biomolecules to selectively achieve anti-cancer benefits through numerous photo/chemotherapies (PCT), including photothermal therapy, photodynamic therapy, and magnetic hyperthermia, a combination of therapies to achieve the best treatment regimen for patients that cannot be treated either by surgery or radiation alone. Among the novel two-dimensional clay-based bio-inorganic nanohybrids, LDH could enhance the photo-stability and drug release controllability of the PCT agents, which would, in turn, improve the overall phototherapeutic performance. This review article highlights the most recent advances in LDH-based two-dimensional clay-bio-inorganic nanohybrids for the aforementioned applications.
Topics: Clay; Drug Delivery Systems; Humans; Hydroxides; Photochemotherapy
PubMed: 36233164
DOI: 10.3390/ijms231911862 -
Nature Reviews. Clinical Oncology Nov 2020Light-activated, photosensitizer-based therapies have been established as safe modalities of tumour ablation for numerous cancer indications. Two main approaches are... (Review)
Review
Light-activated, photosensitizer-based therapies have been established as safe modalities of tumour ablation for numerous cancer indications. Two main approaches are available: photodynamic therapy, which results in localized chemical damage in the target lesions, and photothermal therapy, which results in localized thermal damage. Whereas the administration of photosensitizers is a key component of photodynamic therapy, exogenous photothermal contrast agents are not required for photothermal therapy but can enhance the efficiency and efficacy of treatment. Over the past decades, great strides have been made in the development of phototherapeutic drugs and devices as cancer treatments, but key challenges have restricted their widespread clinical use outside of certain dermatological indications. Improvements in the tumour specificity of photosensitizers, achieved through targeting or localized activation, could provide better outcomes with fewer adverse effects, as could combinations with chemotherapies or immunotherapies. In this Review, we provide an overview of the current clinical progress of phototherapies for cancer and discuss the emerging preclinical bioengineering approaches that have the potential to overcome challenges in this area and thus improve the efficiency and utility of such treatments.
Topics: Clinical Trials as Topic; Humans; Nanotechnology; Neoplasms; Photochemotherapy; Photosensitizing Agents; Photothermal Therapy; Research Design; Treatment Outcome
PubMed: 32699309
DOI: 10.1038/s41571-020-0410-2 -
Indian Journal of Dermatology,... 2010The concept of phototherapy and photochemotherapy is not new, and sophisticated ultraviolet (UV) treatment modalities are available for almost three decades. However,... (Review)
Review
The concept of phototherapy and photochemotherapy is not new, and sophisticated ultraviolet (UV) treatment modalities are available for almost three decades. However, phototherapy has not been used in children as extensively as in adults, probably due to long-term safety concerns. Photochemotherapy (psoralen plus UVA) is not considered to be safe in the younger age group. UV therapies can be useful treatment options for children with selected dermatological conditions provided they are used under carefully controlled conditions. Presently there is insufficient data available to provide recommendations regarding the safe maximum dose and duration of phototherapy in children. Developments of new UV delivery systems and devices are aimed at improving the safety and efficacy of phototherapy. In this review, we discuss the published literature on phototherapy and photochemotherapy in children, drawbacks of their use in pediatric population and future prospects.
Topics: Child; Contraindications; Humans; India; Photochemotherapy; Phototherapy; Skin Diseases
PubMed: 20826991
DOI: 10.4103/0378-6323.69074 -
Transfusion and Apheresis Science :... Jun 2017Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic... (Review)
Review
Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms. Considering to widespread utilization of ECP as a therapeutic strategy, we performed review on current literature of ECP, regarding the treatment strategies, monitoring protocols and technical aspects in chronic and acute GVHD.
Topics: Graft vs Host Disease; Health Planning Guidelines; Humans; Photochemotherapy
PubMed: 28359604
DOI: 10.1016/j.transci.2017.01.006 -
Tidsskrift For Den Norske Laegeforening... Oct 1991Photochemotherapy of cancer is a new modality of cancer treatment now being evaluated in clinical trials worldwide. It is based on injection of photosensitizing and... (Review)
Review
Photochemotherapy of cancer is a new modality of cancer treatment now being evaluated in clinical trials worldwide. It is based on injection of photosensitizing and tumour-localizing dyes followed by exposure of the tumour region to intense light, usually from a laser. A large number of different types of tumours respond to photochemotherapy. However, for photochemotherapy to be efficient, it is absolutely essential that the entire tumour can be reached by light. Thus photochemotherapy is rarely efficient for tumours thicker than 5-7 mm, unless the light is applied interstitially through fibres. Fibre optics can also be used for endoscopic applications. It has been reported that extracorporeal photochemotherapy of T-cells, using 8-methoxypsoralene as sensitizer, has given good clinical results in patients suffering from the erythrodermic form of cutaneous T-cell lymphoma. Extracorporeal photochemotherapy for elimination of residual tumour cells from autologous bone marrow grafts is also being evaluated.
Topics: Humans; Neoplasms; Photochemotherapy
PubMed: 1948902
DOI: No ID Found -
Veterinary Journal (London, England :... Mar 2018Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective... (Comparative Study)
Comparative Study Review
Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective photosensitiser dyes, tissue oxygen and targeted illumination to generate cytotoxic reactive oxygen species (ROS) within the tumour. In addition to directly acting on tumour cells, PDT damages and restricts tumour microvasculature, and causes a local inflammatory response that stimulates an immune response against the tumour. Unlike surgery or radiotherapy, the surrounding extracellular matrix is unaffected by PDT; thus, tissue healing is excellent and PDT seldom causes scars. This, combined with the ease of light application, has made PDT a popular treatment for cancers and pre-cancerous conditions in human beings. Moreover, because photosensitiser dyes are fluorescent and selectively accumulate in tumour tissues, they can additionally be used to visualise and discriminate tumour from normal tissues, thereby improving the accuracy of tumour surgery. In veterinary practice, PDT has been used successfully for treatment of superficial squamous cell carcinomas of the feline nasal planum; urinary tract, urinary bladder and prostate neoplasia in dogs; and equine sarcoids. The purpose of this article is to provide a comparative review of the current literature on PDT in human and veterinary medicine, and to establish a basis for future development of PDT in veterinary medicine.
Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Horse Diseases; Horses; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents
PubMed: 29486883
DOI: 10.1016/j.tvjl.2017.11.012