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Natural Product Research Jul 2022Phytochemical investigation of Oliver staminate flowers provided twenty-seven compounds, including 11 triterpenes (-), 4 fatty acids (-), 1 coumarin (), 1 chromone (),...
Phytochemical investigation of Oliver staminate flowers provided twenty-seven compounds, including 11 triterpenes (-), 4 fatty acids (-), 1 coumarin (), 1 chromone (), 7 flavonoids (-) and 3 cyclopeptide alkaloids (-). Compounds , , , and were reported for the first time in the genus . Their structures were determined by nuclear magnetic resonance, mass spectroscopy, optical rotation, circular dichroism spectroscopy analyses and comparison with literature data. The anti-arthritic activity of these compounds was also evaluated in this study. The result showed , , , and could significantly inhibit proliferation of fibroblast-like synovial cells from rats with IC values ranging from 11.83 to 50.12 μM. Furthermore, the chemotaxonomic significance of the isolated compounds has also been discussed. and might possess chemotaxonomic value for staminate flowers.
Topics: Animals; Eucommiaceae; Flavonoids; Flowers; Phytochemicals; Rats; Triterpenes
PubMed: 33307830
DOI: 10.1080/14786419.2020.1858411 -
Natural Product Research Nov 2022The first phytochemical analysis on the leaves of J.F. Bailey & C.T. White collected in Rome was reported in this work. The study evidenced the presence of four...
The first phytochemical analysis on the leaves of J.F. Bailey & C.T. White collected in Rome was reported in this work. The study evidenced the presence of four compounds , 7,4'''-dimethoxy-agathisflavone (), 7,7''-dimethoxy-cupressuflavone (), dactylifric acid () and shikimic acid () which were identified by means of spectroscopic techniques. Compounds () were reported in the species for the first time as well as this is the second report on the presence of dactylifric acid () in the whole Araucariaceae family. The absence of diterpenoids from the studied accession is also important. All these chemotaxonomic aspects were discussed.
Topics: Phytochemicals; Plant Leaves; Araucariaceae; Diterpenes
PubMed: 34957868
DOI: 10.1080/14786419.2021.2018435 -
Natural Product Research Feb 2020is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by...
is popularly known as 'penicillin' and used as an anti-inflammatory and for wound healing. The objective of this work was the phytochemical study of the species by analytical techniques such as LC-MS/MS and GC-MS. Twenty-seven compounds were identified, five by LC-MS and 22 by GC-MS analysis. All compounds identified by LC-MS are flavonoids. However, several classes were found in GC-MS analysis, such as hydrocarbons, diterpenes, monoterpenes, vitamin and carotenoid derivatives, phytosterols and triterpenes. In the analysis, it is suggested the presence of 27 substances, of which 23 are unpublished for the species, that reaffirms the importance of this study and the contribution to chemical knowledge.
Topics: Amaranthaceae; Anti-Inflammatory Agents; Carotenoids; Chromatography, Liquid; Flavonoids; Gas Chromatography-Mass Spectrometry; Phytochemicals; Phytosterols; Plant Extracts; Tandem Mass Spectrometry; Terpenes; Wound Healing
PubMed: 30600700
DOI: 10.1080/14786419.2018.1533827 -
Critical Reviews in Eukaryotic Gene... 2017The genus Cuscuta, of the family Cuscutaceae, is present in plants and has been traditionally used medicinally against many diseases and conditions, notably depression,... (Review)
Review
The genus Cuscuta, of the family Cuscutaceae, is present in plants and has been traditionally used medicinally against many diseases and conditions, notably depression, mental illness, headache, spleen disease, jaundice, diabetes mellitus, and hypertension. Large numbers of phytochemical constituents such as alkaloids, flavonoids, lignins, oxygen heterocyclic compounds, steroids, fatty acids, phenolic acids, resin glycosides, and polysaccharides have been isolated from different species of Cuscuta. Ethnopharmacological studies conducted on such constituents have also been shown Cuscuta to possess anticancer, antiviral, antispasmodic, antihypertensive, anticonvulsant, antibacterial, antioxidant, diuretic, and hair-growth activity. Many tribes and traditional communities have long used the different forms of Cuscuta for treatment and prevention of many diseases. In this article, we comprehensively summarize relevant data regarding the phytochemical, ethnopharmacological, and traditional therapeutic uses of Cuscuta. In addition, we review the parts of the plants that are used as traditional therapeutic agents, their regions of existence, and their possible modes of action. To conclude, we provide evidence and new insights for further discovery and development of natural drugs from Cuscuta. We show that further studies are needed to investigate the mechanism of action and safety profile of phytochemical constituents isolated from Cuscuta.
Topics: Cuscuta; Ethnopharmacology; Phytochemicals
PubMed: 28845763
DOI: 10.1615/CritRevEukaryotGeneExpr.2017019193 -
Journal of Ethnopharmacology Apr 2015Platycodon grandiflorus (Jacq.) A. DC., the sole species in genus Platycodon A. DC. (Campanulaceae) has a long history of use as a traditional herbal medicine for the... (Review)
Review
ETHNOPHARMACOLOGICAL RELEVANCE
Platycodon grandiflorus (Jacq.) A. DC., the sole species in genus Platycodon A. DC. (Campanulaceae) has a long history of use as a traditional herbal medicine for the treatments of cough, phlegm, sore throat, lung abscess, chest pain, dysuria, and dysentery. As a legal medicine and dietary supplement, it is also frequently used as an ingredient in health foods and vegetable dishes. The aim of this review is to provide up-to-date information on the botanical characterization and distribution, ethnopharmacology, phytochemistry, pharmacology, and toxicity of Platycodon grandiflorus based on literature published in recent years. It will build a foundation for further study of the mechanism of action and the development of better therapeutic agents and healthy products from Platycodon grandiflorus.
MATERIAL AND METHODS
All of the available information on Platycodon grandiflorus was collected via electronic search (using PubMed, SciFinder Scholar, CNKI, TPL (www.theplantlist.org), Google Scholar, Baidu Scholar, and Web of Science).
RESULTS
A comprehensive analysis of the literature obtained through the above-mentioned sources confirmed that ethno-medical uses of Platycodon grandiflorus have been recorded in China, Japan, Mongolia, and Korea for thousands of years. A phytochemical investigation revealed that this product contains steroidal saponins, flavonoids, polyacetylenes, sterols, phenolics, and other bioactive compounds. Crude extracts and pure compounds isolated from Platycodon grandiflorus exhibited significant anti-inflammatory and immunostimulatory effects. They also showed valuable bioactive effects, such as anti-tumor, anti-oxidant, anti-diabetic, anti-obesity, hepatoprotective and cardiovascular system effects, among others.
CONCLUSIONS
In light of its long traditional use and the modern phytochemical and pharmacological studies summarized here, Platycodon grandiflorus has been demonstrated to show a strong potential for therapeutic and health-maintaining uses. Both the extracts and chemical components isolated from the plant showed a wide range of biological activities. Thus, more studies on the pharmacological mechanisms of its main active compounds (e.g., platycodin D, D2) need to be conducted. In addition, as one of the most popular traditional herbal medicines, clinical studies of the main therapeutic aspects, toxicity and adverse effects of Platycodon grandiflorus will also undoubtedly be the focus of future investigation.
Topics: Animals; Ethnobotany; Ethnopharmacology; Humans; Phytochemicals; Phytotherapy; Platycodon
PubMed: 25666431
DOI: 10.1016/j.jep.2015.01.052 -
Biomedicine & Pharmacotherapy =... Dec 2017
Topics: Animals; Antioxidants; Humans; Inflammation; Oxidative Stress; Phytochemicals; Xanthones
PubMed: 28716565
DOI: 10.1016/j.biopha.2017.07.031 -
Molecules (Basel, Switzerland) Jan 2022Asian lotus has long been consumed as a food and herbal drug that provides several health benefits. The number of studies on its biological activity is significant, but...
Asian lotus has long been consumed as a food and herbal drug that provides several health benefits. The number of studies on its biological activity is significant, but research at the population level to investigate the variation in phytochemicals and biological activity of each population which is useful for a more efficient phytopharmaceutical application strategy remains needed. This present study provided the frontier results to fill-in this necessary gap to investigating the phytopharmaceutical potential of perianth and stamen, which represent an important part for Asian traditional medicines, from 18 natural populations throughout Thailand by (1) determining their phytochemical profiles, such as total contents of phenolic, flavonoid, and anthocyanin, and (2) determining the antioxidant activity of these natural populations using various antioxidant assays to examine different mechanisms. The result showed that Central is the most abundant floristic region. The stamen was higher in total phenolic and flavonoid contents, whereas perianth was higher in monomeric anthocyanin content. This study provided the first description of the significant correlation between phytochemical contents in perianth compared with stamen extracts, and indicated that flavonoids are the main phytochemical class. This analysis indicated that the stamen is a richer source of flavonoids than perianth, and provided the first report to quantify different flavonoids accumulated in stamen and perianth extracts under their native glycosidic forms at the population level. Various antioxidant assays revealed that major flavonoids from prefer the hydrogen atom transfer mechanism when quenching free radicals. The significant correlations between various phytochemical classes and the different antioxidant tests were noted by Pearson correlation coefficients and emphasized that the antioxidant capability of an extract is generally the result of complex phytochemical combinations as opposed to a single molecule. These current findings offer the alternative starting materials to assess the phytochemical diversity and antioxidant potential of for phytopharmaceutical sectors.
Topics: Antioxidants; Nelumbo; Phytochemicals; Plant Extracts; Plant Leaves; Thailand
PubMed: 35163946
DOI: 10.3390/molecules27030681 -
Natural Product Research Aug 2020(Lojac.) Mattei (Pinaceae) is a species living in a very small population only in a confined area of Sicily. In this study, the dichloromethane extract of the leaves...
(Lojac.) Mattei (Pinaceae) is a species living in a very small population only in a confined area of Sicily. In this study, the dichloromethane extract of the leaves was analyzed. Apart from three already known metabolites namely dehydroabietic acid; maltol; and rheosmin, previously detected in other species of , a lanostane derivative was isolated. Its chemical structure was elucidated by means of extensive spectroscopic methods.
Topics: Abies; Abietanes; Butanones; Molecular Structure; Phenols; Phytochemicals; Pinaceae; Plant Extracts; Plant Leaves; Pyrones; Sicily; Spectrum Analysis
PubMed: 30873863
DOI: 10.1080/14786419.2019.1576044 -
Annals of Clinical Microbiology and... Aug 2014Medicinal plants have always been part of human culture and have the potential to cure different diseases caused by microorganisms. In Pakistan, biologists are mainly... (Review)
Review
Medicinal plants have always been part of human culture and have the potential to cure different diseases caused by microorganisms. In Pakistan, biologists are mainly focusing on plants' antimicrobial activities against Escherichia coli due to its increasing resistance to antibiotics. In total, extracts from 34 ethnomedicinally valuable Pakistani plants were reported for in-vitro anti-E. coli activities. Mostly methanolic extracts of medicinal plants were used in different studies, which have shown comparatively higher inhibitory activities against E. coli than n-hexane and aqueous extracts. It has been found that increasing concentration (mg/ml) of methanolic extract can significantly increase (p<0.01) anti-E. coli activities. Not all medicinal plants are extracted in solvents others than above, which should also be tested against E. coli. Moreover, medicinal plant species must be fully explored phytochemically, which may lead to the development of new drugs.
Topics: Anti-Bacterial Agents; Escherichia coli; Humans; Medicine, Traditional; Pakistan; Phytochemicals; Plant Extracts; Plants, Medicinal
PubMed: 25135359
DOI: 10.1186/s12941-014-0040-6 -
Chemistry & Biodiversity Jul 2022Phytochemical investigation of the aerial part of Laportea bulbifera (Siebold & Zucc.) Wedd. (L. bulbifera) showed the isolation of seventeen compounds, including five...
Phytochemical investigation of the aerial part of Laportea bulbifera (Siebold & Zucc.) Wedd. (L. bulbifera) showed the isolation of seventeen compounds, including five flavonoids (1-4 and 6), one terpenoid (5), five phenolic acids (7-11), one coumarin (12), two steroids (13-14), and three alkaloids (15-17). Structure elucidations of these compounds were performed on the basis of extensive NMR experiments and compared with the published data in the references. It is remarkable that compounds (3-5) were firstly isolated from the Urticaceae family, compounds (3-8, 11 and 15-17) were firstly obtained from genus Laportea. Furthermore, the result of the chemotaxonomic significance discussion showed that compounds (2-4) may can be served as compound fingerprints to distinguish between species of L. bulbifera and genus Urtica, and what' more, we proposed a bold conjecture that isoflavones can distinguish between species of L. bulbifera and genus Urtica. At the same time, the molecular docking method was used to evaluate the inhibitory effect of these compounds on human steroid 5α-reductase 2 (SRD5α2). The results showed that compounds (1-4 and 6) had better expected effects than the positive drug finasteride can by effectively binding to the active sites of SRD5α2. This study assisted in the future phytochemical and chemotaxonomic research on genus Laportea. Simultaneously, this research provided the theoretical evidence for the application of L. bulbifera in treating benign prostatic hyperplasia (BPH).
Topics: Computational Biology; Humans; Molecular Docking Simulation; Phytochemicals; Plant Extracts; Urticaceae
PubMed: 35620918
DOI: 10.1002/cbdv.202200070