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Journal of Clinical Pharmacology Oct 1987Pimozide is a neuroleptic drug with dopamine receptor and calcium channel blocking activity that is used in the treatment of Tourette's syndrome. A comparison of the... (Comparative Study)
Comparative Study
Pimozide is a neuroleptic drug with dopamine receptor and calcium channel blocking activity that is used in the treatment of Tourette's syndrome. A comparison of the pharmacokinetics of pimozide was made in children and adults with Tourette's syndrome. Seven adults (ages 23-39) and four children (ages 6-13) received a single 2-mg oral dose of pimozide and a minimum of nine blood samples were collected over a four-day period. Mean elimination half-life of pimozide in children was 66 hours compared with 111 hours in adults with Tourette's syndrome. Significant interindividual variability of pimozide pharmacokinetics was found in both adults and children with Tourette's syndrome. The pharmacokinetics of pimozide in patients with Tourette's syndrome differs from that reported in adult populations with chronic schizophrenia.
Topics: Administration, Oral; Adolescent; Adult; Child; Female; Humans; Male; Pimozide; Tourette Syndrome
PubMed: 3480904
DOI: 10.1002/j.1552-4604.1987.tb02995.x -
BMJ Case Reports May 2014
Topics: Antipsychotic Agents; Delusional Parasitosis; Humans; Male; Middle Aged; Pimozide
PubMed: 24872482
DOI: 10.1136/bcr-2013-202850 -
Psychopharmacology 1984Pimozide treatment (1.0 and 2.0 mg/kg) decreased free feeding in rats. The animals were presented daily with 35 meal segments, each consisting of five 45-mg pellets;...
Pimozide treatment (1.0 and 2.0 mg/kg) decreased free feeding in rats. The animals were presented daily with 35 meal segments, each consisting of five 45-mg pellets; pimozide resulted in longer mean latencies to initiate eating, longer mean eating times per segment (duration scores) and more pellets left uneaten. The increase in durations was progressive both within and across test sessions; toward the end of the final session many pellets were left uneaten. Failure to initiate eating of the first pellet of each segment was rare, and was always preceded by failure to eat the fifth pellet of the preceding meal segment. To assess whether either the increase in latencies or the increase in durations reflected an impairment of absolute response capability, 'best scores' in the pimozide and control conditions were compared; the shortest latencies and durations in the pimozide condition were as 'good' as those of the control condition. However, the animals generally produced 'best' scores on fewer trials in the pimozide condition. An exception was on day 1 of testing, when the frequency of 'best' latencies was higher in the pimozide condition. The fact that the 'best' scores under pimozide equalled the 'best' scores under vehicle suggests that the pimozide-treated animals had the motoric capacity to respond normally. The facts that the pimozide-treated animals did not perform to the demonstrated limits of that capacity in a normal percentage of trials and that performance on days 2 and 3 of testing were 'worse' than performance on day 1 of testing suggest that pimozide causes a motivational deficit that has not been widely recognized.
Topics: Animals; Feeding Behavior; Male; Motivation; Pimozide; Rats; Rats, Inbred Strains; Reward; Time Factors
PubMed: 6441944
DOI: 10.1007/BF00431448 -
Pharmacology, Biochemistry, and Behavior Oct 1981Pimozide pretreatment produced a dose-dependent attenuation of acquisition of a lever-pressing habit motivated by food reward in hungry rats. No evidence of learning was...
Pimozide pretreatment produced a dose-dependent attenuation of acquisition of a lever-pressing habit motivated by food reward in hungry rats. No evidence of learning was seen in animals treated at 1.0 mg/kg, minimal learning was seen at 0.5 mg/kg, and retarded learning which ultimately did reach normal asymptote was seen at 0.25 mg/kg. Thus primozide attenuates the response acquisition function as well as the previously studied response maintenance function of food reward.
Topics: Animals; Conditioning, Operant; Depression, Chemical; Food; Male; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine
PubMed: 7291269
DOI: 10.1016/0091-3057(81)90225-2 -
Psychiatric Services (Washington, D.C.) Jun 1999
Topics: Antipsychotic Agents; Delusions; Humans; Male; Middle Aged; Pimozide
PubMed: 10375160
DOI: 10.1176/ps.50.6.837 -
Activitas Nervosa Superior Jun 1986Pimozide was tried in the treatment of delusion of parasitosis (a type of monosymptomatic hypochondriacal psychosis), a syndrome that is found with increasing frequency.... (Clinical Trial)
Clinical Trial
Pimozide was tried in the treatment of delusion of parasitosis (a type of monosymptomatic hypochondriacal psychosis), a syndrome that is found with increasing frequency. Ten patients were selected on the basis of unambiguously defined psychopathological criteria. Pimozide therapy was assessed by means of placebo control and the double-blind method using a rating scale evolved for this particular therapy. The results have quite definitely proved the effect of small doses (two to eight mg per day) of pimozide compared to the administration of a placebo. The very few side-effects observed could easily be influenced. The dynamics of the regression of the psychopathological symptoms suggest that the efficacy of pimozide therapy is decisively linked to the central dopamine receptor blocking effect of the drug.
Topics: Aged; Double-Blind Method; Drug Evaluation; Female; Humans; Hypochondriasis; Male; Middle Aged; Parasitic Diseases; Pimozide; Time Factors
PubMed: 3739562
DOI: No ID Found -
The Journal of Clinical Psychiatry Jun 1983
Topics: Delusions; Humans; Parasites; Pimozide; Pruritus
PubMed: 6853463
DOI: No ID Found -
Pharmacology, Biochemistry, and Behavior Feb 1981Rats were trained to lever-press for water on a schedule of continuous reinforcement, then tested every fourth session on five occasions either under conditions of...
Rats were trained to lever-press for water on a schedule of continuous reinforcement, then tested every fourth session on five occasions either under conditions of non-reinforcement or following injections of the dopamine receptor blocker pimozide (0.5 or 1.0 mg/kg) or the injection vehicle. The low dose of pimozide did not significantly attenuate responding until the fifth session. The high dose attenuated responding on all occasions, with residual responding decreasing progressively across repeated drug sessions. Responding in the pimozide conditions was never less than that of the non-reinforced control group. Responding in each condition was strongest in the early minutes of a session. After five sessions, rats were switched from the pimozide condition to the non-reinforced condition (or vice-versa) for one additional test day. Decreased responding continued for rats transferred from non-reinforcement to pimozide though not for rats transferred from pimozide to non-reinforcement. These data suggest a role for brain dopamine in behavior; they reflect the same patterns as have been seen with food reinforcement and with several centrally-acting reinforcers.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior; Pimozide; Rats; Reinforcement, Psychology; Water
PubMed: 7208559
DOI: 10.1016/0091-3057(81)90243-4 -
Archives of Neurology Apr 1990
Topics: Female; Humans; Male; Pimozide; Trigeminal Neuralgia
PubMed: 2322128
DOI: 10.1001/archneur.1990.00530040022011 -
Clinical Evidence Dec 2005
Review
Topics: Analgesics, Non-Narcotic; Carbamazepine; Humans; Pimozide; Trigeminal Neuralgia
PubMed: 16620467
DOI: No ID Found