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Transactions of the American... 1974
Clinical Trial
Topics: Clinical Trials as Topic; Drug Evaluation; Humans; Movement Disorders; Phenothiazines; Pimozide
PubMed: 4618685
DOI: No ID Found -
Acta Psychiatrica Scandinavica Jul 1994Pimozide, a dopamine receptor antagonist, dopamine uptake inhibitor and L-type calcium channel blocker, is used in children suffering from Tourette syndrome (TS), but... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
Pimozide, a dopamine receptor antagonist, dopamine uptake inhibitor and L-type calcium channel blocker, is used in children suffering from Tourette syndrome (TS), but its effect on frequently comorbid attention deficit hyperactivity disorder (ADHD) is unknown. We have characterized the cognitive effects of pimozide and haloperidol in TS in relation to comorbid ADHD. Sixty-six consecutive outpatients with TS (DSM-III-R), ages 7-16, were randomly assigned to pimozide, haloperidol or medication-free clinical treatment and evaluated cognitively after 6 weeks. Continuous performance task (CPT) and memory search efficiency were compared across treatments. Treatment, comorbid ADHD and their interaction were significant on the CPT task. Pimozide treatment was superior to haloperidol and improved memory search efficiently over the no-drug condition.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Calcium Channels; Child; Cognition; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Pimozide; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Severity of Illness Index; Tourette Syndrome; Treatment Outcome
PubMed: 7976448
DOI: 10.1111/j.1600-0447.1994.tb01546.x -
Biological Psychiatry Sep 1997
Clinical Trial
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pimozide; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology
PubMed: 9285089
DOI: 10.1016/S0006-3223(97)00227-8 -
The British Journal of Psychiatry : the... Aug 1978Response to a token economy was assessed in male chronic schizophrenic in-patients who were given, in a double-blind cross-over trial, pimozide (up to 20 mg daily) or... (Clinical Trial)
Clinical Trial
Response to a token economy was assessed in male chronic schizophrenic in-patients who were given, in a double-blind cross-over trial, pimozide (up to 20 mg daily) or chlorpromazine )up to 1,000 mg daily), each for three months. After six months there was little change in the patients' mental state, but general ward behaviour and token-rewarded "target" behaviours improved significantly. There were no statistically significant between-drug differences, but the trend was that general ward behaviour, but not token-rewarded behaviour, improved more on pimozide. The patients who showed initiative and cooperated best with staff were those whose token-rewarded behaviour was most satisfactory.
Topics: Behavior Therapy; Chlorpromazine; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Hospitals, Psychiatric; Humans; Long-Term Care; Male; Middle Aged; Pimozide; Reward; Schizophrenia; Token Economy
PubMed: 98196
DOI: 10.1192/bjp.133.2.179 -
Acta Psychiatrica Scandinavica Dec 1982Eighteen female inpatients were included in a double-blind placebo-controlled cross-over study aimed at testing the hypothesis that dopamine blockade may enhance the... (Clinical Trial)
Clinical Trial
Eighteen female inpatients were included in a double-blind placebo-controlled cross-over study aimed at testing the hypothesis that dopamine blockade may enhance the effectiveness of behavior therapy in the short-term weight restoration of anorexia nervosa patients. The patients were given a uniform contingency management program and, after a baseline period, they alternatingly (3-week periods) received pimozide (4 to 6 mg) or a placebo. During the first two periods pimozide almost significantly enhanced the weight gain induced by the behavior therapy program and beneficially influenced the patients' attitude towards treatment.
Topics: Adolescent; Adult; Anorexia Nervosa; Behavior Therapy; Body Weight; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Pimozide; Random Allocation
PubMed: 6758492
DOI: 10.1111/j.1600-0447.1982.tb04501.x -
Lancet (London, England) Jan 1977
Clinical Trial Comparative Study Randomized Controlled Trial
Topics: Clinical Trials as Topic; Drug Evaluation; Haloperidol; Humans; Male; Pimozide; Tourette Syndrome
PubMed: 63706
DOI: 10.1016/s0140-6736(77)91126-6 -
Canadian Journal of Psychiatry. Revue... Jun 1988
Topics: Adult; Body Image; Delusions; Humans; Hypochondriasis; Male; Pimozide
PubMed: 3409159
DOI: 10.1177/070674378803300531 -
Bioorganic & Medicinal Chemistry Letters Sep 2014STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in...
STATs are transcription factors acting as intracellular signaling after stimulation with cytokines, growth factors and hormones. STAT5 is also constitutively active in many forms of cancers, including chronic myelogenous leukemia, acute lymphoblastic leukemia and Hodgkin's lymphoma. Recently, literature reported that the neuroleptic drug pimozide inhibits STAT5 phosphorylation inducing apoptosis in CML cells. We undertook an investigation from pimozide structure, obtaining simple derivatives with cytotoxic and STAT5-inhibitory activity, two of them markedly more potent than pimozide.
Topics: Apoptosis; Cell Cycle; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Fusion Proteins, bcr-abl; Humans; K562 Cells; Molecular Structure; Phosphorylation; Pimozide; STAT5 Transcription Factor; Structure-Activity Relationship
PubMed: 25131537
DOI: 10.1016/j.bmcl.2014.07.069 -
Psychopharmacology 1980The effect of pimozide on conditioned reinforcement was determined by comparing rate of lever pressing for a tone in groups previously treated with or without the drug...
The effect of pimozide on conditioned reinforcement was determined by comparing rate of lever pressing for a tone in groups previously treated with or without the drug when the tone was paired with food. Eight groups of six to eight rats each received three phases of training in a two-lever box. The pre-exposure phase measured the operant rate of pressing the two levers, one of which produced a 3s tone. In the conditioning phase, with the levers absent, the tone was paired with food over four sessions. The test phase again measured the rate of pressing the two levers. In an undrugged experimental group (i.e., Paradigm group), the number of presses on the tone lever significantly increased from the pre-exposure to the test phase, thereby confirming that the procedure could establish conditioned reinforcement. A control group receiving tones and pellets randomly during the conditioning phase also showed conditioned reinforcement but a group receiving negatively correlated tones and pellets did not. Groups receiving the dopamine-receptor blocker pimozide (1.0 mg/kg) prior to each conditioning session failed to show conditioned reinforcement in the test session. Control groups ruled out state dependent learning and drug-induced performance impairments as explanations of this pimozide-related effect. These data may indicate a possible role for dopamine neurons in mediating the control of behavior by certain positive reinforcing stimuli.
Topics: Animals; Conditioning, Operant; Food; Male; Motor Activity; Pimozide; Rats; Reinforcement, Psychology
PubMed: 6776557
DOI: 10.1007/BF00432132 -
Acta Psychiatrica Belgica 1979Forty patients with some "social maladjustments" or disturbed interpersonal relationship under 2 mg pimozide (Orap: a 24 h long-acting neuroleptic) for six to twelve...
Forty patients with some "social maladjustments" or disturbed interpersonal relationship under 2 mg pimozide (Orap: a 24 h long-acting neuroleptic) for six to twelve months. Concomitant but complementary medication was kept unchanged. Control was based on: long-term investigation (1/2 - 1 year), quantification, use of two scales. Statistical evaluation of the changes in "cardinal symptoms" showed a significant improvement in tension, disorders of sleep, intellectual disturbances, cardiovascular symptoms and gastrointestinal complaints. More detailed analysis of the other 27-item rating scale revealed a dramatic improvement in anxiety and paranoidism. The overall appreciation shows that: 25 patients responded well or very well to pimozide, eight did moderately, seven poorly. Neurasthenia and related states with predominant asthenia turned out to be no indication for pimozide treatment. Except for some cases of increased fatigue, tolerance was exceptionally good. The trial showed that extra patience is required from the therapist as a clinical onset of one to two months is not uncommon.
Topics: Adult; Aged; Drug Evaluation; Female; Humans; Male; Middle Aged; Personality Disorders; Pimozide; Psychiatric Status Rating Scales; Social Behavior Disorders
PubMed: 554447
DOI: No ID Found