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Archives of Ophthalmology (Chicago,... Apr 2006
Topics: Brain Diseases; Child, Preschool; Cysts; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Infant; Magnetic Resonance Imaging; Male; Pineal Gland; Pinealoma; Retinal Neoplasms; Retinoblastoma
PubMed: 16606893
DOI: 10.1001/archopht.124.4.595 -
Neuro-Chirurgie 2015The papillary tumor of the pineal region (PTPR) was described as a distinct new entity for the first time in 2003 by our team and has been included in the last 2007 WHO... (Review)
Review
BACKGROUND AND PURPOSE
The papillary tumor of the pineal region (PTPR) was described as a distinct new entity for the first time in 2003 by our team and has been included in the last 2007 WHO classification of tumors of the Central Nervous System. We describe the histopathological characterization of PTPR and present a review of the literature.
METHODS
The description of the histological and immunological features of PTPR is based on the 2007 WHO classification.
RESULTS
PTPR affects both children and adults, and mostly young adults in the third decade. PTPR is a neuroepithelial tumor occurring in the vicinity of the pineal gland, and characterized by its papillary architecture. The papillae are lined by multi-layered cuboidal to columnar epithelioid tumoral cells arranged in perivascular pseudorosettes. Immunohistochemistry shows strong reactivity for cytokeratins, particularly for cytokeratin 18. On electron microscopy, PTPR reveals ultrastructural features indicative of ependymal differentiation, including abundant microvilli at the apical cell pole. The differential diagnosis includes a variety of other papillary tumors, most notably papillary ependymoma, choroid plexus papilloma, papillary meningioma, and metastatic papillary carcinoma in adults. On the basis of ultrastructural and immunohistochemical features, it has been suggested that a PTPR arises from specialized cytokeratin-positive and nestin-positive ependymal cells that are derived from the subcommissural organ. Although the precise histological grading criteria of PTPR remain to be defined, its biological behavior may correspond to WHO grade II or III.
Topics: Animals; Brain Neoplasms; Carcinoma, Papillary; Diagnosis, Differential; Ependymoma; Humans; Immunohistochemistry; Pineal Gland
PubMed: 24556386
DOI: 10.1016/j.neuchi.2013.04.011 -
Clinical Pediatrics Sep 1997
Topics: Child, Preschool; Cysts; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Imaging; Pineal Gland; Puberty, Precocious
PubMed: 9307090
DOI: 10.1177/000992289703600909 -
Acta Neurochirurgica Aug 2012We present the first report on familial pineocytoma. The propositus, a 31-year-old man, presented with incontinence due to a cystic and haemorrhagic tumour of the pineal...
We present the first report on familial pineocytoma. The propositus, a 31-year-old man, presented with incontinence due to a cystic and haemorrhagic tumour of the pineal region. His 34-year-old sister, who had suffered from tinnitus for several years, also had a pineal tumour. Histopathology following tumour resection revealed pineocytomas (WHO grade 1). Cerebral MRI examinations of the patient's brother and father did not reveal any pineal region abnormalities. Their mother had developed breast cancer at the age of 43. Although not impossible, it is rather unlikely that pineocytomas occurring in siblings are pure coincidence because of the rarity of this type of tumour.
Topics: Brain Neoplasms; Female; Humans; Magnetic Resonance Imaging; Male; Pineal Gland; Pinealoma; Siblings
PubMed: 22699425
DOI: 10.1007/s00701-012-1402-5 -
Journal of Neurosurgery May 2000
Topics: Adolescent; Brain Diseases; Brain Neoplasms; Diagnosis, Differential; Epidermal Cyst; Germinoma; Humans; Male; Pineal Gland
PubMed: 10794322
DOI: 10.3171/jns.2000.92.5.0909 -
Neuro-Chirurgie 2015Numerous tumour types can occur in the pineal region. Because these tumours are uncommon and heterogeneous, it is often difficult to establish optimal treatment... (Review)
Review
Numerous tumour types can occur in the pineal region. Because these tumours are uncommon and heterogeneous, it is often difficult to establish optimal treatment strategies based on comparative clinical trials. To date, the role of radiosurgery for the treatment of pineal region tumours remains controversial. This report of a 10-year single-department experience and review of the literature focuses on the spectrum of pathologic features found in these pineal parenchymal tumours and on the interest of radiosurgery in their management. Considering pineocytomas, although these tumours have been considered to be radioresistant to fractionated radiotherapy, our results are in agreement with similar results reported in the literature in suggesting that radiosurgery may be an alternative to surgical resection or an adjuvant therapy when the resection is not optimal. When dissemination occurs after radiosurgery, however, craniospinal radiation and chemotherapy are necessary. Radiosurgery has also proven its interest in the treatment of germinomas as an alternative to encephalic radiotherapy with limited long-term damage. Regarding the other pathologies, radiosurgery can be considered as part of a multimodal treatment including surgery, chemo-radiotherapy and its role still has to be clearly defined.
Topics: Brain Neoplasms; Humans; Pineal Gland; Pinealoma; Radiosurgery; Supratentorial Neoplasms; Treatment Outcome
PubMed: 24874722
DOI: 10.1016/j.neuchi.2013.11.007 -
American Journal of Kidney Diseases :... Sep 1981
Topics: Adult; Brain Diseases; Cysts; Female; Humans; Pineal Gland; Polycystic Kidney Diseases; Tomography, X-Ray Computed
PubMed: 7332002
DOI: 10.1016/s0272-6386(81)80037-6 -
World Neurosurgery Dec 2018Retinal optical coherence tomography (OCT) is a noninvasive high-resolution imaging technique, which is considered a biomarker of neurodegeneration. Several intracranial...
BACKGROUND
Retinal optical coherence tomography (OCT) is a noninvasive high-resolution imaging technique, which is considered a biomarker of neurodegeneration. Several intracranial lesions can induce retrograde neurodegeneration which can be assessed using OCT. The cysts of the pineal region are usually asymptomatic and most often are an incidental radiologic finding.
CASE DESCRIPTION
We describe the case of a 50-year-old woman with an arachnoid cyst of the pineal region who complained of visual symptoms for 3 months. Bilateral macular thinning was demonstrated by OCT both on the preoperative and postoperative examinations, without any other clinical findings that could explain the results.
CONCLUSIONS
We suggest that the retinal alteration is caused by retrograde neurodegeneration secondary to the pineal region mass.
Topics: Arachnoid Cysts; Diplopia; Female; Headache; Humans; Magnetic Resonance Imaging; Middle Aged; Pineal Gland; Retina; Retrograde Degeneration; Tomography, Optical Coherence; Vision Disorders
PubMed: 30253993
DOI: 10.1016/j.wneu.2018.09.094 -
The American Journal of Forensic... Sep 2014Pineal cysts are usually asymptomatic; however, they may rarely cause symptoms such as chronic headache, paroxysmal headache with gaze paresis, postural syncope, loss of...
Pineal cysts are usually asymptomatic; however, they may rarely cause symptoms such as chronic headache, paroxysmal headache with gaze paresis, postural syncope, loss of consciousness, and sudden death. A 30-year-old woman with no specific medical history except chronic headache was found collapsed in a public toilet per se. Postmortem examination revealed no external injuries or internal diseases except a cystic lesion of the pineal gland. Histologic examination showed an internal cyst surrounded by glial tissues and pineal parenchyma that was diagnosed as a glial cyst of the pineal gland. Although the pineal cyst cannot be confirmed as the cause of death, it was considered, as no other cause was evident. Herein, we report a pineal cyst considered as an assumed cause of death.
Topics: Adult; Brain Diseases; Cysts; Death, Sudden; Female; Forensic Pathology; Humans; Neuroglia; Pineal Gland
PubMed: 25062343
DOI: 10.1097/PAF.0000000000000107 -
Pediatric Neurosurgery 2021Meningiomas in childhood are infrequently seen. Furthermore, they are extremely rare at a pineal location with few reported cases above 5-years of age. We present a very...
INTRODUCTION
Meningiomas in childhood are infrequently seen. Furthermore, they are extremely rare at a pineal location with few reported cases above 5-years of age. We present a very young child with a large pineal region meningioma which mimicked the usually occurring pathologies at this site.
CASE PRESENTATION
A 2.5-year-old child presented with symptoms of raised intracranial pressure. MRI demonstrated a homogenously enhancing pineal lesion with small cystic areas. After an initial cerebrospinal fluid evaluation for germ cell tumors, the child underwent excision of the lesion by the Krause approach. The tumor showed no definitive dural attachment, had well-defined arachnoid interface, and was completely excised. The final histopathology was meningioma.
CONCLUSION
Although unusual, we highlight the importance of considering meningiomas among the childhood pineal region lesions, given their good outcome with total resection. Also, pertinent brief literature of the pediatric pineal region meningiomas has been provided. An assessment of preoperative and intraoperative features (clear arachnoid plane) along with adjuncts such as frozen studies can help discern various entities of this region, and decide the extent of excision.
Topics: Child; Child, Preschool; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Pineal Gland; Supratentorial Neoplasms
PubMed: 33596576
DOI: 10.1159/000513406