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Neurosurgery Clinics of North America Jul 2011Pineoblastomas (PBs) represent the most aggressive of the pineal parenchymal tumors. Routine treatment consists of operative management of obstructive hydrocephalus and... (Review)
Review
Pineoblastomas (PBs) represent the most aggressive of the pineal parenchymal tumors. Routine treatment consists of operative management of obstructive hydrocephalus and cerebrospinal fluid studies followed by maximal resection and adjuvant chemotherapy/radiotherapy, resulting in a median survival of 20 months. Important prognostic factors for survival of patients with PB include extent of resection, age at presentation, disseminated disease, and craniospinal radiotherapy. Novel strategies being evaluated for the treatment of PB include high-dose chemotherapy with autologous stem cell therapy, stereotactic radiosurgery, and histone deacetylase inhibitors.
Topics: Chemoradiotherapy; Humans; Neurosurgical Procedures; Pinealoma; Radiosurgery; Stem Cell Transplantation; Survival Rate
PubMed: 21801990
DOI: 10.1016/j.nec.2011.05.001 -
Cancer Nov 1982A pineal gland tumor in a 57-year-old man proved to be lethal within six months despite radiotherapy. The tumor was demonstrated to be a pineocytoma at autopsy but it...
A pineal gland tumor in a 57-year-old man proved to be lethal within six months despite radiotherapy. The tumor was demonstrated to be a pineocytoma at autopsy but it was unusual is that papillary structures constituted a prominent component of it. We report that papillary features may be a component of pineocytic neoplasms and that they may have prognostic significance. Papillary pineal parenchymal neoplasms should be distinguished from other benign and malignant papillary neoplasms which also occur in the pineal region.
Topics: Autopsy; Brain Neoplasms; Humans; Male; Middle Aged; Neoplasm Invasiveness; Pineal Gland; Pinealoma
PubMed: 7116304
DOI: 10.1002/1097-0142(19821101)50:9<1789::aid-cncr2820500924>3.0.co;2-a -
Neurologia Medico-chirurgica Dec 1997A 58-year-old male suffered a massive intratumoral hemorrhage after placement of a ventriculoperitoneal shunt before treatment for pineocytoma. At admission, he...
A 58-year-old male suffered a massive intratumoral hemorrhage after placement of a ventriculoperitoneal shunt before treatment for pineocytoma. At admission, he complained of headache, urinary incontinence, gait disturbance, and recent memory disturbance. His neurological examination revealed impaired memory and papilledema from hydrocephalus. Two days after the placement of the ventriculoperitoneal shunt, he suddenly became stuporous and Parinaud's sign appeared. Computed tomography showed a massive intratumoral hemorrhage occupying the third ventricle which had extended into the lateral ventricle. The infratentorial supracerebellar approach was used to remove the hematoma and the tumor. The histological diagnosis was pineocytoma. Intratumoral hemorrhage in pineocytoma after the placement of a ventriculoperitoneal shunt is rare, but should be kept in mind when a ventriculoperitoneal shunt is placed before a craniotomy.
Topics: Cerebral Hemorrhage; Contrast Media; Gadolinium DTPA; Humans; Hydrocephalus; Magnetic Resonance Imaging; Male; Middle Aged; Ocular Motility Disorders; Pinealoma; Pituitary Neoplasms; Syndrome; Tomography, X-Ray Computed; Ventriculoperitoneal Shunt
PubMed: 9465590
DOI: 10.2176/nmc.37.911 -
Cancer Genetics and Cytogenetics Dec 1992The cytogenetic findings based on G-banding in a pineocytoma detected in a 29-year-old woman are reported. The chromosomal study showed numerical alterations involving...
The cytogenetic findings based on G-banding in a pineocytoma detected in a 29-year-old woman are reported. The chromosomal study showed numerical alterations involving chromosomes X, 5, 8, 11, 14, and 22, structural alterations of chromosomes 1, 3, 12, and 22, as well as various markers. Tumors of the pineal region are infrequent, and this is the first report of a pineocytoma studied cytogenetically.
Topics: Adult; Brain Neoplasms; Chromosome Aberrations; Chromosome Banding; Female; Humans; Karyotyping; Monosomy; Pinealoma; Trisomy
PubMed: 1486561
DOI: 10.1016/0165-4608(92)90341-5 -
The Journal of Pathology Sep 1970
Topics: Brain Neoplasms; Cell Differentiation; Cerebral Ventricles; Dilatation; Humans; Male; Neuroblastoma; Neuroglia; Neurons; Pinealoma; Staining and Labeling
PubMed: 4101025
DOI: 10.1002/path.1711020106 -
Neuropathology : Official Journal of... Feb 2011Pineocytomas (PCs) most frequently occur in adults, but only three cases have been reported in women older than 70 years. In PCs, cytologic pleomorphism, accompanied by...
Pineocytomas (PCs) most frequently occur in adults, but only three cases have been reported in women older than 70 years. In PCs, cytologic pleomorphism, accompanied by ganglion cells intensely expressing neuronal markers, has been described and the presence of pleomorphic cells may lead to an erroneous upgrading of the tumor. We report an unusual case of pleomorphic pineocytoma in an older patient who presented with a slowly growing tumor adjacent to residual pineal gland. The immunohistological markers of the tumoral tissue and the remnant normal pineal tissue were evaluated and compared. In the neoplasm, the large number of cells labeled for neuronal markers, including many pleomorphic cells, confirmed previous findings that a neuronal immunophenotype is common in PC. Reactivity for synaptophysin was stronger in the tumor than the pineal gland, whereas neurofilament protein reactivity was stronger in the pineal gland than the tumor. The neoplastic cells, but not the pineal gland, were reactive for chromogranin A. This dense core vesicle-associated protein immunolabeling is an interesting diagnostic marker for PCs, which makes it possible to distinguish normal pineal parenchyma with low or negative expression from tumoral tissue. This case illustrates that, even though PCs are low-grade tumors, they can increase in size and surgery appears a valuable option.
Topics: Aged; Biomarkers, Tumor; Brain Neoplasms; Chromogranin A; Humans; Immunohistochemistry; Male; Pineal Gland; Pinealoma
PubMed: 20573029
DOI: 10.1111/j.1440-1789.2010.01133.x -
Acta Neurochirurgica Aug 2012Because the pineal gland produces melatonin, it is suggested to be involved in the regulation of sleep and circadian rhythm, though there is scant proof of this. Tumors...
BACKGROUND
Because the pineal gland produces melatonin, it is suggested to be involved in the regulation of sleep and circadian rhythm, though there is scant proof of this. Tumors of the pineal gland are rare and various in terms of histological and biological malignancy. We evaluated the occurrence of subjective sleep disturbances in nine patients who underwent a pinealectomy due to pineocytoma WHO°I without additional therapy.
METHODS
Patients with intracranial low-grade lesions and patients without a craniotomy who underwent a microscopic lumbar discectomy were matched to our study group by gender, age, and date of surgery. We used standardized sleep questionnaires on sleepiness during the daytime, sleep disturbances, and general pathologic sleep patterns.
RESULTS
Patients who underwent a craniotomy either without a pinealectomy (7.2 ± 2.0 points) or with a pinealectomy experienced increased sleep disturbances (6.6 ± 1.3 points) compared to patients who had a lumbar discectomy (2.8 ± 0.4 points), according to the Pittsburgh Sleep Quality Index (PSQI) (p < 0.05). Moreover, sleep disturbances as measured by the insomnia severity index (ISI) were most pronounced in patients who underwent a craniotomy without a pinealectomy (10.4 ± 3.1 points) compared to patients who underwent a pinealectomy or discectomy (5.9 ± 1.9 and 3.3 ± 1.3 points).
CONCLUSIONS
Pinealectomy itself did not cause specific sleep impairment, but craniotomy in general did. This interesting and clinically relevant finding needs further investigation.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Melatonin; Pineal Gland; Pinealoma; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Surveys and Questionnaires
PubMed: 22706841
DOI: 10.1007/s00701-012-1409-y -
Ryoikibetsu Shokogun Shirizu 2000
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No Shinkei Geka. Neurological Surgery Feb 1991
Review
Topics: Brain Neoplasms; Humans; Immunohistochemistry; Intermediate Filament Proteins; Membrane Proteins; Neurofilament Proteins; Phosphopyruvate Hydratase; Pineal Gland; Pinealoma; Synaptophysin
PubMed: 1902558
DOI: No ID Found -
Neurosurgery Clinics of North America Jul 2011The role of radiosurgery in the management of pineal region tumors is still in its incipient stages, although over the past few years its use has expanded, both as a... (Review)
Review
The role of radiosurgery in the management of pineal region tumors is still in its incipient stages, although over the past few years its use has expanded, both as a primary treatment modality and as an adjunct to conventional therapies. This article gives a detailed overview of the recent literature regarding the merits of stereotactic radiosurgery to pineal region tumors, and offers guidelines for the practicing neurosurgeon and neuro-oncologist for the incorporation of radiosurgery into the clinical management of these difficult lesions.
Topics: Combined Modality Therapy; Humans; Pinealoma; Radiosurgery; Survival Rate; Treatment Outcome
PubMed: 21801991
DOI: 10.1016/j.nec.2011.05.002