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Salud Publica de Mexico 1963
Topics: Communicable Disease Control; Epidemiology; Humans; Mexico; Penicillins; Pinta
PubMed: 14088055
DOI: No ID Found -
Anais Brasileiros de Dermatologia E... Mar 1951
Topics: Pinta
PubMed: 14952777
DOI: No ID Found -
Gaceta Medica de Mexico Jan 1960
Topics: Humans; Pinta
PubMed: 13794205
DOI: No ID Found -
Archives of Dermatology and Syphilology Apr 1948
Topics: Humans; Hypopigmentation; Occupations; Pinta; Vitiligo
PubMed: 18886310
DOI: No ID Found -
Boletin de La Asociacion Medica de... Oct 1968
Topics: Adult; Biopsy; Hand Dermatoses; Humans; Male; Pinta; Puerto Rico
PubMed: 5249905
DOI: No ID Found -
World Journal of Clinical Oncology Mar 2021Small cell lung cancer (SCLC) accounts for approximately 20% of all lung cancers. The main treatment is chemotherapy (Ch). However, the addition of radiotherapy... (Review)
Review
Small cell lung cancer (SCLC) accounts for approximately 20% of all lung cancers. The main treatment is chemotherapy (Ch). However, the addition of radiotherapy significantly improves overall survival (OS) in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch. Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients. The 5-year OS rate in patients with limited-stage disease (non-metastatic) is slightly higher than 30%, but less than 5% in patients with extensive-stage disease (metastatic). The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis, planning, and treatment of SCLC. These guidelines emphasise treatment fields, radiation techniques, fractionation, concomitant treatment, and the optimal timing of Ch and radiotherapy. Finally, we discuss the main indications for reirradiation in local recurrence.
PubMed: 33767969
DOI: 10.5306/wjco.v12.i3.115 -
Infection, Genetics and Evolution :... Jul 2018Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp.... (Review)
Review
Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum). Several species of nonhuman primates in Africa are infected by treponemes genetically undistinguishable from known human TPE strains. Besides Treponema pallidum, the equally uncultivable Treponema carateum causes pinta in humans. In lagomorphs, Treponema paraluisleporidarum ecovar Cuniculus and ecovar Lepus are the causative agents of rabbit and hare syphilis, respectively. All uncultivable pathogenic treponemes harbor a relatively small chromosome (1.1334-1.1405 Mbp) and show gene synteny with minimal genetic differences (>98% identity at the DNA level) between subspecies and species. While uncultivable pathogenic treponemes contain a highly conserved core genome, there are a number of highly variable and/or recombinant chromosomal loci. This is also reflected in the occurrence of intrastrain heterogeneity (genetic diversity within an infecting bacterial population). Molecular differences at several different chromosomal loci identified among TPA strains or isolates have been used for molecular typing and the epidemiological characterization of syphilis isolates. This review summarizes genome structure of uncultivable pathogenic treponemes including genetically variable regions.
Topics: Animals; DNA, Bacterial; Humans; Lagomorpha; Molecular Typing; Rabbits; Treponema; Treponemal Infections
PubMed: 29578082
DOI: 10.1016/j.meegid.2018.03.015 -
Journal of the American Academy of... Dec 1994
Topics: Developing Countries; Humans; Pinta; Syphilis; Yaws
PubMed: 7962768
DOI: 10.1016/s0190-9622(09)80094-7 -
Medicina Sep 1950
Topics: Penicillins; Pinta
PubMed: 14775370
DOI: No ID Found