-
The American Journal of Dermatopathology Jan 2020Pityriasis lichenoides (PL) is an infrequent skin disorder. The clinical manifestations are usually specific enough for a reliable diagnosis, although the...
INTRODUCTION
Pityriasis lichenoides (PL) is an infrequent skin disorder. The clinical manifestations are usually specific enough for a reliable diagnosis, although the histopathological assessment of a biopsy is sometimes needed to differentiate between PL and a range of other diseases. The objectives of this study were to review cases of PL managed in our hospital, confirm the classical histopathological features of PL, and identify signs that may be of value in the diagnosis of PL.
MATERIALS AND METHODS
All cases of PL assessed in our pathology department between January 2007 and December 2017 were retrieved, and all slides were reviewed. Cases were selected only if a diagnosis of PL was initially suggested by a dermatologist and then confirmed by the histopathological assessment.
RESULTS
Seventy-one cases met the study criteria. The following features were almost always present: vacuolar changes or necrotic keratinocytes (100%), both superficial and deep lymphocytic infiltrates (99%), and the infiltration of lymphocytes into the adnexal epithelium (97%). The inflammatory cells were always small- to medium-sized lymphocytes. There were no eosinophilic infiltrates. Superficial perivascular and/or intraepidermal red blood cells were observed in 83% of cases.
DISCUSSION
We highlighted the presence of a deep dermal lymphocytic infiltrate, with a "T-shaped" periadnexal arrangement along the full length of the follicular and sudoral epithelia. This might be a feature that enables the differentiation of PL from other diseases. Our findings also prompted a number of physiopathological hypotheses for PL.
CONCLUSIONS
Our present results confirmed the classical histological aspects of PL and provided some useful new diagnostic features.
Topics: Adolescent; Child; Female; Hair Follicle; Humans; Male; Pityriasis Lichenoides; Young Adult
PubMed: 31880634
DOI: 10.1097/DAD.0000000000001448 -
The Australasian Journal of Dermatology Feb 2022Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of... (Observational Study)
Observational Study
BACKGROUND/OBJECTIVES
Pityriasis lichenoides chronica (PLC) lesions are reported to subside with post-inflammatory hypopigmentation (PIH); hence, the most widely perceived nature of hypopigmented macules in PLC is PIH. However, to the best of our knowledge, no studies describing histopathological findings in these lesions are reported in literature. The aim of this study is to evaluate the hypopigmented lesions encountered in PLC patients and to shed light on their histopathological features.
METHODS
A cross-sectional observational study included twenty-one patients with PLC recruited in a period of twelve months. Clinical characteristics of each patient were collected. A skin biopsy from hypopigmented lesions whenever present was taken and assessed with routine haematoxylin and eosin stain.
RESULTS
Seventeen patients (81%) were less than 13 years old. Most patients (85.7%) demonstrated diffuse distribution of lesions. Hypopigmented lesions were present on the face in 12 (57.14%) patients. Histopathologically, hypopigmented lesions showed features of post-inflammatory hypopigmentation in 19% of patients, residual PLC in 52.4% and active PLC 28.6% of patients.
CONCLUSION
Hypopigmented lesions in PLC were noted mainly in younger ages, histopathologically they may show features of active or residual disease, beyond post-inflammatory hypopigmentation. Consequently active treatment for patients presenting predominantly with hypopigmented lesions could be required to control the disease.
Topics: Adolescent; Adult; Child; Child, Preschool; Cross-Sectional Studies; Female; Humans; Hypopigmentation; Male; Pityriasis Lichenoides
PubMed: 34751445
DOI: 10.1111/ajd.13746 -
Archives of Dermatology Sep 1982
Topics: Child; Chronic Disease; Humans; Male; Parapsoriasis; Pityriasis
PubMed: 7114860
DOI: No ID Found -
European Journal of Dermatology : EJD Jun 2023
Topics: Humans; Pityriasis Lichenoides; Antibodies, Monoclonal, Humanized
PubMed: 37594343
DOI: 10.1684/ejd.2023.4483 -
The Journal of Dermatology Nov 2020
Topics: Dermatomyositis; Humans; Lung Diseases, Interstitial; Pityriasis Lichenoides
PubMed: 33464622
DOI: 10.1111/1346-8138.15556 -
Journal of Drugs in Dermatology : JDD May 2020Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be...
BACKGROUND
Pityriasis lichenoides chronica, a papulosquamous disorder often considered a subtype of pityriasis lichenoides. It is considered a clonal T-cell disorder, which may be associated with cutaneous T-cell lymphoma that may develops in response to foreign antigens.
CASE PRESENTATION
We present a 38-year-old male patient with ankylosing spondylitis who was on treatment with etanercept. After 8 weeks of treatment, the patient presented with scaly erythematous papules, on the back and arms. He was diagnosed clinically with pityriasis lichenoides chronica.
CONCLUSION
Pityriasis lichenoides chronica should be included among the broad clinical spectrum of chronic inflammatory skin diseases which may occur during treatment with TNF-alpha antagonists. J Drugs Dermatol. 2020;19(5): doi:10.36849/JDD.2020.2191.
Topics: Administration, Cutaneous; Adult; Etanercept; Glucocorticoids; Humans; Male; Pityriasis Lichenoides; Spondylitis, Ankylosing; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha
PubMed: 32484616
DOI: No ID Found -
Journal of Cutaneous Medicine and... 2024
Topics: Humans; Pityriasis Lichenoides; Skin Pigmentation; Male; Female; Skin
PubMed: 38268408
DOI: 10.1177/12034754241229349 -
Indian Journal of Dermatology,... 2020
Topics: Anti-Bacterial Agents; Azithromycin; Child; Combined Modality Therapy; Diagnosis, Differential; Humans; Male; Pityriasis Lichenoides; Rubella Vaccine; Ultraviolet Therapy
PubMed: 32474500
DOI: 10.4103/ijdvl.IJDVL_48_18 -
The Australasian Journal of Dermatology Feb 2002Two patients presented with acrally located papulosquamous lesions that were polymorphic and had an identical morphology to those of pityriasis lichenoides. The lesions...
Two patients presented with acrally located papulosquamous lesions that were polymorphic and had an identical morphology to those of pityriasis lichenoides. The lesions remained localized to the feet and ankles for years. Multiple skin biopsies had the histopathological features of pityriasis lichenoides. In one biopsy syringotropic lymphocytes and early syringolymphoid hyperplasia were observed. This rare variant of pityriasis lichenoides may be under-recognized and misdiagnosed as it resembles a variety of papulosquamous disorders particularly psoriasis.
Topics: Administration, Topical; Aged; Biopsy, Needle; Female; Follow-Up Studies; Humans; Leg Dermatoses; Male; Middle Aged; Pityriasis Lichenoides; Prednisolone; Severity of Illness Index
PubMed: 11869214
DOI: 10.1046/j.1440-0960.2002.00564.x -
Expert Review of Anti-infective Therapy Jun 2016Paraviral exanthems are skin diseases suspected to be caused by viruses, with a single virus-exanthem relationship not universally accepted. Although most paraviral... (Review)
Review
INTRODUCTION
Paraviral exanthems are skin diseases suspected to be caused by viruses, with a single virus-exanthem relationship not universally accepted. Although most paraviral exanthems are self-remitting, accurate diagnoses are important as some patients might develop complications. Some of the differential diagnoses might cause serious complications, and some paraviral exanthems might lead to complications for at-risk groups such as pregnant women. Moreover, some paraviral exanthems might be symptomatic such as the development of severe pruritus, with relief of such being crucial in the plan of management. Patients and carers of patients should also be counselled regarding the aetiologies, clinical features, and prognoses of the exanthems concerned.
AREAS COVERED
We covered the clinical manifestations and managements of pityriasis rosea, pityriasis lichenoides, and Gianotti-Crosti syndrome. Expert Commentary: Most patients with pityriasis rosea do not need any active intervention. Symptomatic relief of the pruritus would be adequate. For patients with pityriasis rosea that are serious, extensive, or causing severe impacts of their quality of life, oral acyclovir could be considered. For pityriasis lichenoides, managements would be depending on the type of the exanthem such as the acute form (pityriasis lichenoides et varioliformis acuta, also known as Mucha Habermann disease) the chronic form (pityriasis lichenoides chronic Juliusberg's disease), and the febrile ulceronecrotic Mucha-Habermann disease, which is a complication of the acute form. The management of Gianotti-Crosti syndrome is mainly symptomatic. The need for long-term follow-up for chronic complications of the underlying viral infections is still controversial.
Topics: Acrodermatitis; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antiviral Agents; Combined Modality Therapy; Diagnosis, Differential; Exanthema; Humans; Phototherapy; Pityriasis Lichenoides; Pityriasis Rosea; Skin Diseases, Viral
PubMed: 27144956
DOI: 10.1080/14787210.2016.1184084