-
Lancet (London, England) Jul 1987
Topics: Administration, Oral; Ampicillin; Endocarditis, Bacterial; Humans; Pivampicillin; Streptococcal Infections
PubMed: 2885568
DOI: 10.1016/s0140-6736(87)92785-1 -
Tidsskrift For Den Norske Laegeforening... Jun 1990
Review
Topics: Amdinocillin; Amdinocillin Pivoxil; Ampicillin; Carnitine; Humans; Pivampicillin
PubMed: 2195708
DOI: No ID Found -
Tidsskrift For Den Norske Laegeforening... Nov 1977
Topics: Amoxicillin; Ampicillin; Bacteria; Humans; Penicillin Resistance; Pivampicillin
PubMed: 244370
DOI: No ID Found -
Antimicrobial Agents and Chemotherapy Nov 1974Studies on pivampicillin hydrochloride and ampicillin trihydrate, administered in capsules to healthy volunteers, indicated that pivampicillin was absorbed more...
Studies on pivampicillin hydrochloride and ampicillin trihydrate, administered in capsules to healthy volunteers, indicated that pivampicillin was absorbed more efficiently from the gastrointestinal tract than ampicillin. Average peak concentrations of ampicillin in the serum after doses equimolar to 250 mg of ampicillin were 6.8 mug/ml at 56 min with pivampicillin and 1.96 mug/ml at 1 h 24 min with ampicillin. The maximal concentration after pivampicillin treatment was also higher than that recorded when twice the equimolar dose of ampicillin, which averaged 3.2 mug/ml at 1 h 42 min, was used. The urinary excretion of ampicillin, expressed as a percentage of the administered dose, averaged 67 to 73 and 25 to 29% after administration of pivampicillin and ampicillin, respectively. The bioavailability of ampicillin, taken as the area under the serum curve, obtained with pivampicillin at a 250-mg ampicillin dose level was superior to that obtained with a 500-mg dose of ampicillin. Comparison of a suspension intended for children, containing the pivampicillin free base with a suspension of ampicillin trihydrate, emphasized the difference recorded for the capsule preparations. Administration of pivampicillin with a meal rich in fat and protein had no depressant effect on the absorption. Concurrent administration of probenecid caused higher and prolonged concentrations of ampicillin in the serum.
Topics: Absorption; Adult; Anti-Bacterial Agents; Biological Availability; Fasting; Humans; Middle Aged; Pivampicillin; Probenecid; Suspensions
PubMed: 15825306
DOI: 10.1128/AAC.6.5.563 -
Drug and Therapeutics Bulletin Jul 1989
Comparative Study Review
Topics: Administration, Oral; Amoxicillin; Ampicillin; Animals; Bacterial Infections; Humans; Pivampicillin
PubMed: 2519122
DOI: No ID Found -
Scandinavian Journal of Infectious... 199024 patients (4-65 years old; median age 29 years) excreting shigella bacteria greater than 8 weeks were treated with the combination pivampicillin (0.25 g)/pivmecillinam...
24 patients (4-65 years old; median age 29 years) excreting shigella bacteria greater than 8 weeks were treated with the combination pivampicillin (0.25 g)/pivmecillinam (0.20 g), 2 tablets 3 times a day for 14 days. 23/24 patients (96%) were culture negative after treatment. The one patient that did not respond to treatment carried a strain with intermediate sensitivity to mecillinam and resistance to ampicillin. It is concluded that pivampicillin/pivmecillinam is effective for patients excreting shigella bacteria.
Topics: Adolescent; Adult; Amdinocillin; Amdinocillin Pivoxil; Ampicillin; Ampicillin Resistance; Carrier State; Child; Child, Preschool; Drug Combinations; Dysentery, Bacillary; Female; Humans; Male; Middle Aged; Pivampicillin; Shigella
PubMed: 2259872
DOI: 10.3109/00365549009027108 -
Genitourinary Medicine Aug 1988In a randomised single blind study, pivampicillin was compared with erythromycin in women with urogenital Chlamydia trachomatis infections. The pivampicillin dosage was... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
In a randomised single blind study, pivampicillin was compared with erythromycin in women with urogenital Chlamydia trachomatis infections. The pivampicillin dosage was 700 mg twice a day and the erythromycin dosage 500 mg twice a day for seven days. Follow up took place on days 7 and 14 after the start of treatment. All 26 women treated with pivampicillin were culture negative for chlamydiae at the first and second follow up visits. All 23 women who received erythromycin were culture negative at the first follow up visit, but one was culture positive at the second follow up visit. Gastrointestinal side effects were recorded in five patients receiving pivampicillin and in nine receiving erythromycin. Two patients receiving erythromycin were withdrawn from treatment because of gastrointestinal disturbances, compared with none receiving pivampicillin.
Topics: Adolescent; Adult; Ampicillin; Chlamydia Infections; Chlamydia trachomatis; Drug Evaluation; Erythromycin; Female; Genital Diseases, Female; Humans; Pivampicillin
PubMed: 3169754
DOI: 10.1136/sti.64.4.247 -
The British Journal of Venereal Diseases Dec 1972
Clinical Trial
Topics: Ampicillin; Clinical Trials as Topic; Female; Gonorrhea; Humans; Hydrolysis; Male; Neisseria gonorrhoeae; Penicillin G Procaine; Penicillin Resistance; Sex Factors; Valerates; Vomiting
PubMed: 4631231
DOI: 10.1136/sti.48.6.510 -
Scandinavian Journal of Infectious... 1972
Clinical Trial
Topics: Administration, Oral; Adolescent; Adult; Aged; Ampicillin; Clinical Trials as Topic; Humans; Intestinal Absorption; Kidney Function Tests; Middle Aged; Time Factors
PubMed: 4560876
DOI: 10.3109/inf.1972.4.issue-2.16 -
Current Medical Research and Opinion 1999A prospective, randomised, single-blind comparative trial was carried out to determine whether double beta-lactam treatment with pivampicillin plus pivmecillinam is more... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
Randomised trial of pivampicillin plus pivmecillinam vs. pivampicillin in children and young adults with chronic obstructive pulmonary disease and infection with Haemophilus influenzae.
A prospective, randomised, single-blind comparative trial was carried out to determine whether double beta-lactam treatment with pivampicillin plus pivmecillinam is more effective than pivampicillin alone in the treatment of recurrent and chronic lung infections with Haemophilus influenzae in patients with chronic obstructive pulmonary disease (COPD) or cystic fibrosis (CF). Fifty-six children and young adults with COPD or CF were randomised to the clinical study. The patients were allocated at random to receive perorally either pivmecillinam, 40 mg/kg/day, combined with pivampicillin, 50 mg/kg/day, or pivampicillin 50 mg/kg/day alone for 14 days. A cross-over pharmacokinetic study using the same drugs was carried out in 10 CF patients to determine the antibiotic concentrations in serum and sputum after a single dose of each drug. The clinical study showed no significant differences in clinical scoring, lung function tests or adverse events after treatment with pivampicillin plus pivmecillinam or pivampicillin alone. Follow-up microbiological evaluation 2 and 6 weeks after the end of treatment showed that the offending pathogen was eradicated in 68% of the patients treated with pivampicillin plus pivmecillinam and in 67% of the patients treated with pivampicillin alone. Reinfection with another biotype was more common in the combination group (50% vs. 21%) than in the pivampicillin group. In the pharmacokinetic study the median peak serum concentration occurred two hours after intake of tablets. The efficacy of double beta lactam treatment in lung infections with H. influenzae appears to be equivalent to that of ampicillin on clinical lung symptoms, lung function tests, adverse effects and bacteriology.
Topics: Adolescent; Adult; Amdinocillin Pivoxil; Child; Child, Preschool; Cross-Over Studies; Drug Therapy, Combination; Female; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Lung Diseases, Obstructive; Male; Penicillins; Pivampicillin; Prospective Studies; Single-Blind Method
PubMed: 10640263
DOI: 10.1185/03007999909116501