-
World Neurosurgery Feb 2019Parasellar plasmacytomas are rare tumors arising from the sellar region that should be considered in the differential diagnosis of lesions involving the sella and... (Review)
Review
BACKGROUND
Parasellar plasmacytomas are rare tumors arising from the sellar region that should be considered in the differential diagnosis of lesions involving the sella and clivus. Before surgical pathologic examination, parasellar plasmacytomas have often been misdiagnosed as invasive pituitary adenomas or chordomas owing to the similarity of the clinical presentation and imaging findings.
METHODS
We retrospectively reviewed the data from 5 patients with parasellar plasmacytoma who underwent endonasal endoscopic tumor resection in Beijing Tiantan Hospital from January 2008 to January 2018. Their clinical symptoms, radiological features, and treatment modalities and outcomes were summarized.
RESULTS
We enrolled a total of 5 patients (3 men and 2 women; median age at diagnosis, 54 years; range, 47-61) with parasellar plasmacytoma in the present clinical series. The presenting symptoms mainly included diplopia, headache, and blurred vision. All the patients had undergone endonasal endoscopic surgery combined with adjuvant therapy. After postoperative radiotherapy, complete remission was achieved within a median follow-up period of 41 months (range, 15-120).
CONCLUSIONS
The differential diagnosis of parasellar plasmacytoma with pituitary adenoma and chordoma should include a thorough endocrine workup, neurological examination, and radiological assessment. Our findings support radiotherapy as the main treatment of choice for parasellar plasmacytoma, given its typical feature of relatively high radiosensitivity. Tumor resection through the endonasal endoscopic approach combined with adjuvant radiotherapy could be the optimal initial treatment strategy in long-term control of the lesion and alleviation of neurological symptoms.
Topics: Adenoma; Chordoma; Combined Modality Therapy; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroendoscopy; Pituitary Neoplasms; Plasmacytoma; Radiotherapy; Retrospective Studies; Sphenoid Sinus
PubMed: 30414521
DOI: 10.1016/j.wneu.2018.10.183 -
Acta Neurochirurgica Sep 2008Plasmacytomas are unusual causes of a sellar mass. Occasionally, they can be misdiagnosed as a nonfunctioning adenoma because of radiological and clinical similarities. (Review)
Review
INTRODUCTION
Plasmacytomas are unusual causes of a sellar mass. Occasionally, they can be misdiagnosed as a nonfunctioning adenoma because of radiological and clinical similarities.
LITERATURE REVIEW
We reviewed the pertinent literature and discuss here in the light of an illustrative case of our own.
DISCUSSION
A 70-year-old woman presented with a recurrent hypophysial mass. Initial diagnosis of a nonfunctioning pituitary adenoma was later overruled by a repeat biopsy, which showed a plasmacytoma. The tumor stained positively for CD138 and kappa light chain. Further studies confirmed the diagnosis of multiple myeloma. The patient was successfully treated with radiotherapy followed by systemic chemotherapy. Because they have different therapeutic implications, extramedullary plasmacytomas involving pituitary gland should be considered in the differential diagnosis of a nonfunctioning pituitary mass.
Topics: Adenoma; Aged; Biopsy; Diagnosis, Differential; Female; Humans; Immunoglobulin kappa-Chains; Magnetic Resonance Imaging; Multiple Myeloma; Pituitary Neoplasms; Plasmacytoma; Sella Turcica; Syndecan-1
PubMed: 18726062
DOI: 10.1007/s00701-008-0012-8 -
Optometry (St. Louis, Mo.) May 2010Plasmacytomas are plasma cell tumors that may be a primary or secondary tumor focus, the latter of which are associated with multiple myeloma. We present a rare case of...
BACKGROUND
Plasmacytomas are plasma cell tumors that may be a primary or secondary tumor focus, the latter of which are associated with multiple myeloma. We present a rare case of a solitary extramedullary plasmacytoma involving the conjunctiva.
CASE REPORT
A 33-year-old white man presented with the initial complaint of redness in both eyes, more in his right than left eye. A vascularized conjunctival lesion was noted in his right eye. The patient underwent excisional biopsy, which found a conjunctival plasmacytoma.
CONCLUSION
Although plasmacytomas of the eye and orbit are rare, it is important to be familiar with these tumors that may be associated with multiple myeloma. Definitive diagnosis is made by biopsy and histopathologic examination of the tissue. Plasmacytomas may be treated with external beam radiation, local excision, or radiotherapy after surgical excision. Long-term follow-up, including periodic systemic evaluation, is required to establish that orbital involvement is not an early manifestation of multiple myeloma.
Topics: Adult; Biopsy; Conjunctiva; Conjunctival Neoplasms; Humans; Male; Plasmacytoma
PubMed: 20435269
DOI: 10.1016/j.optm.2009.11.006 -
Medicine Sep 2014Sellar plasmacytoma is a rare cause of sellar lesions. Preoperative diagnosis remains a challenge. We present a 34-year-old Chinese woman with a 25-day history of... (Review)
Review
Sellar plasmacytoma is a rare cause of sellar lesions. Preoperative diagnosis remains a challenge. We present a 34-year-old Chinese woman with a 25-day history of headache and diplopia. A physical examination revealed incomplete left abducens nerve palsy. The initial diagnosis was invasive pituitary adenoma. The patient's condition deteriorated suddenly the day before the arranged operating date, with the hemoglobin level declining from 113 to 70 g/L. The operation was cancelled and further studies confirmed the diagnosis of sellar solitary plasmacytoma that progressed to multiple myeloma. After undergoing radiotherapy, high-dose chemotherapy, and autologous peripheral blood stem cell transplantation, complete remission was achieved on 4 years follow-up. We reviewed the pertinent literature and reached the following conclusions: sellar plasmacytomas with development of multiple myeloma on follow-up more likely happened in men than in women; and if the sellar plasmacytoma does not compress the cranial nerve, transsphenoidal resection should be cautious because the systemic treatment with radiotherapy, chemotherapy, and autologous peripheral blood stem cell transplantation may be more effective with little invasion.
Topics: Adult; China; Diagnosis, Differential; Female; Humans; Multiple Myeloma; Plasmacytoma; Sella Turcica; Skull Neoplasms
PubMed: 25192483
DOI: 10.1097/MD.0000000000000058 -
Vojnosanitetski Pregled Apr 2016The extramedullary plasmacytomas (EMPs) are rare tumors of plasma cell disorders which are rarely found in the duodenum. We presented a case of solitary EMPs involving... (Review)
Review
INTRODUCTION
The extramedullary plasmacytomas (EMPs) are rare tumors of plasma cell disorders which are rarely found in the duodenum. We presented a case of solitary EMPs involving the duodenum and pancreas successfully treated by surgical resection after failure of chemotherapy.
CASE REPORT
A 55-year-old female with previously diagnosed solitary EMP of the duodenum was admitted to our institution after failure of three cycles of vincristine, adriablastine, dexamethasone (VAD) chemotherapy regimen with an upper gastrointestinal obstruction. On admission computed tomography of the abdomen showed tumor in the region of the second part of duodenum and uncinate process of the pancreas with a complete duodenal obstruction. Intraoperatively a tumor formation was in the region of the second duodenal part, originated from the wall of duodenum with the total diameter of 7 x 5 cm, covering the entire circumference of duodenal wall leaded to a narrowing of duodenal lumen to the thigh gap with an upper gastrointestinal obstruction. Infiltration in the head of the pancreas and uncinate process were also found. The Whipple’s procedure was performed but postoperative course was complicated by rapidly refilling chylous ascites which was resolved 4 days after the surgery.
CONCLUSION
Each patient with gastrointestinal EMPs should be considered separately and in timely manner, thus adequate treatment could provide local disease control.
Topics: Antineoplastic Combined Chemotherapy Protocols; Duodenal Neoplasms; Female; Humans; Intestinal Obstruction; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms; Plasmacytoma
PubMed: 29309111
DOI: 10.2298/VSP141031142I -
Anales de Medicina Interna (Madrid,... Oct 1991Isolated presentation of outer bone marrow plasmatic cell neoplasia are non-frequent (less than 10% of all plasmacytomas). Thyroid gland involvement is rarely described.... (Review)
Review
Isolated presentation of outer bone marrow plasmatic cell neoplasia are non-frequent (less than 10% of all plasmacytomas). Thyroid gland involvement is rarely described. A case where immunohistochemistry confirmed the monoclonal type of proliferative cell is presented. Clinical, pathological and diagnosis criteria, as well as response to treatment, are reviewed.
Topics: Aged; Combined Modality Therapy; Female; Humans; Immunoglobulin kappa-Chains; Immunohistochemistry; Lymph Node Excision; Lymphatic Metastasis; Plasmacytoma; Thyroid Neoplasms; Thyroidectomy
PubMed: 1751692
DOI: No ID Found -
Neurosurgical Review 1998Plasmacytoma of the spine is rather common, but solitary occurrence is not. We report two cases of solitary plasmacytomas in the thoracic spine. A 72 year old male and a... (Review)
Review
Plasmacytoma of the spine is rather common, but solitary occurrence is not. We report two cases of solitary plasmacytomas in the thoracic spine. A 72 year old male and a 77 year old male presented with progressive paraparesis. In both cases, magnetic resonance images revealed tumors in the thoracic spine which predominantly occupied the posterior elements of the spine with compression of the spinal cord. Abnormal proteinuria and proteinemia were not detected. The tumors were removed and patients' symptoms improved, the tumors were diagnosed by histopathology to be plasmacytomas. Further neuroradiological studies suggested them to be single lesions, so that the final diagnosis was solitary plasmacytomas. Solitary plasmacytoma should be considered for diagnosis of single spinal lesion even without abnormal proteinemia or proteinuria.
Topics: Aged; Humans; Magnetic Resonance Imaging; Male; Paralysis; Plasmacytoma; Spinal Neoplasms; Thoracic Vertebrae
PubMed: 9795946
DOI: 10.1007/BF02389317 -
Ophthalmic Plastic and Reconstructive... 2012Plasmacytomas are plasma cell neoplasms that rarely involve ocular adnexal tissues as a primary lesion or secondary manifestation of plasma cell myeloma. Only one case...
Plasmacytomas are plasma cell neoplasms that rarely involve ocular adnexal tissues as a primary lesion or secondary manifestation of plasma cell myeloma. Only one case of plasmacytoma involving the lacrimal drainage system, to our knowledge, is described in the literature. The clinical presentation of ocular adnexal primary plasmacytoma typically relates to its mass effect. In this clinicopathologic report, we describe an unusual presentation of primary plasmacytoma of the lacrimal canaliculus as infectious canaliculitis.
Topics: Actinomyces; Actinomycosis; Aged; Biomarkers, Tumor; Combined Modality Therapy; Dacryocystitis; Eye Infections, Bacterial; Eye Neoplasms; Humans; Lacrimal Apparatus Diseases; Male; Plasmacytoma; Radiotherapy Dosage; Radiotherapy, High-Energy
PubMed: 21743365
DOI: 10.1097/IOP.0b013e3182238b75 -
International Journal of Clinical and... 2014Plasmacytomas are monoclonal plasma cells proliferations originating either in localized osseous tissue or in soft tissue (extramedullary plasmacytoma, EMP). Although... (Review)
Review
Plasmacytomas are monoclonal plasma cells proliferations originating either in localized osseous tissue or in soft tissue (extramedullary plasmacytoma, EMP). Although many such lesions are found in the bone marrow, fewer arise in extramedullary tissue. A solitary EMP involving the adrenal gland is extremely rare, with only 7 cases having been reported in the literature thus far. Here, we describe a rare case of solitary EMP in the right adrenal gland of a 26-year-old man that was managed by retroperitoneal laparoscopic resection, with no recurrence during 6-year follow-up.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Biopsy; Humans; Laparoscopy; Male; Plasmacytoma; Time Factors; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 25674290
DOI: No ID Found -
The Journal of Laryngology and Otology Dec 1979Extramedullary plasmacytomas of the head and neck are very uncommon tumours. Three rare cases of extramedullary plasmacytoma are presented-one each in the nose, larynx...
Extramedullary plasmacytomas of the head and neck are very uncommon tumours. Three rare cases of extramedullary plasmacytoma are presented-one each in the nose, larynx and maxilla.
Topics: Adult; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Plasmacytoma
PubMed: 528827
DOI: 10.1017/s002221510008837x