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Current Opinion in Oncology Apr 1990
Review
Topics: Humans; Mesothelioma; Neoplasm Staging; Pleural Neoplasms
PubMed: 2095246
DOI: 10.1097/00001622-199004000-00018 -
Pathology International Oct 2001Pleural malignant mesothelioma (PMM) is a rare tumor and it is commonly seen in the form of multiple nodules or a diffuse tumor. A localized tumor mass in the pleura is...
Pleural malignant mesothelioma (PMM) is a rare tumor and it is commonly seen in the form of multiple nodules or a diffuse tumor. A localized tumor mass in the pleura is extremely rare. Only seven cases have been reported. In this report, we present an additional case of localized PMM and describe the immunohistochemical and flow cytometric findings. A 61-year-old woman, without a history of smoking or asbestos exposure, presented with a severe pain in her right shoulder and arm. Chest radiography showed a solitary mass in the right upper lung field. Computed tomography showed a 5 cm right upper lung mass. Magnetic resonance imaging showed that the mass extended to the wall of the thorax. The patient underwent surgery for total removal of the tumor. Pathology revealed a localized malignant mesothelioma. Immunohistochemical analysis showed that the tumor was strongly and diffusely positive for cytokeratins with high and low molecular weight, and focally positive for vimentin and epithelial membrane antigen (EMA), but it was negative for carcinoembryonic antigen, Factor VIII, alpha-fetoprotein and Leu-M1. Flow cytometry showed an aneuploid DNA content in the tumor. The final diagnosis was localized malignant mesothelioma (epithelial type). The patient showed signs of local recurrence 5 months after surgery, and radiotherapy was given.
Topics: Aneuploidy; Biomarkers, Tumor; Female; Flow Cytometry; Humans; Immunohistochemistry; Keratins; Mesothelioma; Middle Aged; Neoplasm Recurrence, Local; Pleural Neoplasms; Radiography, Thoracic
PubMed: 11881736
DOI: 10.1046/j.1440-1827.2001.01279.x -
The New England Journal of Medicine Oct 2005
Review
Topics: Asbestos; Genetic Therapy; Humans; Mesothelioma; Neoplasm Invasiveness; Neoplasm Staging; Palliative Care; Peritoneal Neoplasms; Pleural Neoplasms; Prognosis
PubMed: 16221782
DOI: 10.1056/NEJMra050152 -
Critical Reviews in Diagnostic Imaging 1993Depending on the location, size, and underlying histologic features, pleural masses may produce a large spectrum of findings. While a number of imaging modalities may be... (Review)
Review
Depending on the location, size, and underlying histologic features, pleural masses may produce a large spectrum of findings. While a number of imaging modalities may be used, plain chest radiographs remain the most common examination in the initial assessment of these patients. In this article, we review the use of two noninvasive techniques: computed tomography and magnetic resonance imaging. For the purpose of this review, localized pleural masses and diffuse pleural masses are discussed separately. Among the various pleural masses, metastatic disease represents the most frequent neoplasm.
Topics: Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Pleura; Pleural Diseases; Pleural Neoplasms; Tomography, X-Ray Computed
PubMed: 8305137
DOI: No ID Found -
Cirugia Y Cirujanos 2021We present a clinical case of a solitary fibrous pleural tumor (TFSP) with abnormal behavior due to its high aggressiveness and poor short-term prognosis, where an ALK...
We present a clinical case of a solitary fibrous pleural tumor (TFSP) with abnormal behavior due to its high aggressiveness and poor short-term prognosis, where an ALK translocation was identified. TFSP is an infrequent tumor, with an estimated incidence of around 8 per 100,000 inhabitants and with few cases reported in the literature. The most common is that it is a neoplasm of benign behavior, with debut as a localized mass and whose The treatment of choice is surgical resection. All the data in the literature contrast with our experience, which we report below.
Topics: Humans; Pleural Neoplasms; Receptor Protein-Tyrosine Kinases; Solitary Fibrous Tumor, Pleural; Syndrome
PubMed: 34762616
DOI: 10.24875/CIRU.20001346 -
The Lancet. Oncology Jun 2004Because of a lack of effective treatments, survival from diffuse pleural mesothelioma remains poor. Many people do not think that treatments for this disease are... (Comparative Study)
Comparative Study Review
Because of a lack of effective treatments, survival from diffuse pleural mesothelioma remains poor. Many people do not think that treatments for this disease are effective. The understanding of the biology of mesothelioma relevant to the apoptosis-resistant phenotype has been slow to advance. However, this is now changing, and strategies for rational therapeutic drug development are emerging that have the potential to change the natural history and improve survival in the increasing number of patients that will be diagnosed in the next two decades. This review discusses recent developments in apoptosis biology that are specific to mesothelioma and the therapeutic implications for this aggressive cancer.
Topics: Antineoplastic Agents; Apoptosis; Biopsy, Needle; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Immunohistochemistry; Male; Mesothelioma; Neoplasm Staging; Pleural Neoplasms; Prognosis; Risk Assessment; Signal Transduction; Survival Analysis; Tumor Cells, Cultured
PubMed: 15172356
DOI: 10.1016/S1470-2045(04)01492-5 -
The American Journal of Surgical... Jul 2005Localized malignant mesotheliomas are uncommon sharply circumscribed tumors of the serosal membranes with the microscopic appearance of diffuse malignant mesothelioma... (Comparative Study)
Comparative Study
Localized malignant mesotheliomas are uncommon sharply circumscribed tumors of the serosal membranes with the microscopic appearance of diffuse malignant mesothelioma but without any evidence of diffuse spread. Little is known about their behavior. We report 23 new cases. The mean age at presentation was 63 years, and the sex ratio was approximately 2:1 (male/female). Twenty-one tumors were pleural and 2 were peritoneal. Sixteen tumors reproduced microscopic patterns of diffuse epithelial mesotheliomas, 6 had mixed epithelial and sarcomatous patterns, and 1 was purely sarcomatous. After surgical excision of the tumor, 10 of 21 patients with follow-up data were alive without evidence of disease from 18 months to 11 years after diagnosis. Patients who died had developed local recurrences and metastases, but none had diffuse pleural spread. Localized malignant mesotheliomas should be separated from diffuse malignant mesotheliomas because of their localized presentation, quite different biologic behavior, and far better prognosis.
Topics: Adult; Aged; Female; Humans; Male; Mesothelioma; Middle Aged; Neoplasm Invasiveness; Peritoneal Neoplasms; Pleural Neoplasms; Prognosis; Treatment Outcome
PubMed: 15958850
DOI: 10.1097/01.pas.0000165529.78945.dc -
Clinics in Chest Medicine Jun 2006Malignant mesothelioma is increasing in incidence globally and has no known cure. Its unique clinical feature of local infiltration along tissue planes makes it a... (Review)
Review
Malignant mesothelioma is increasing in incidence globally and has no known cure. Its unique clinical feature of local infiltration along tissue planes makes it a difficult neoplasm to manage. There have been few randomized controlled trials regarding treatment options, although these have increased in recent years, and results are eagerly awaited. This article summarizes important advances in the management of mesothelioma, especially diagnostic and therapeutic aspects.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Genetic Predisposition to Disease; Humans; Magnetic Resonance Imaging; Mesothelioma; Neoplasm Staging; Photochemotherapy; Pleural Neoplasms; Positron-Emission Tomography; Prognosis; Thoracoscopy
PubMed: 16716822
DOI: 10.1016/j.ccm.2006.01.004 -
Medicina (Kaunas, Lithuania) 2008To evaluate efficacy of diagnostic procedures, results of surgery, and complications in malignant pleural diseases. (Comparative Study)
Comparative Study
OBJECTIVE
To evaluate efficacy of diagnostic procedures, results of surgery, and complications in malignant pleural diseases.
MATERIAL AND METHODS
From 1999 to 2006, 169 patients underwent treatment in the Department of Thoracic Surgery and Oncology, Institute of Oncology, Vilnius University. Patients were divided into two groups: group I, patients with primary pleural malignant diseases (93 patients, 55.0%), and group II, secondary pleural tumors (76 patients, 45%). Of the 76 patients, 40 patients (52.6%) were diagnosed with metastatic pleural tumors and 36 patients (47.4%) with tumors invading parietal pleura. We used noninvasive and invasive methods for diagnosis. Noninvasive methods included chest x-ray, chest computed tomography, magnetic resonance imaging, chest ultrasound, positron emission tomography/computed tomography (performed in Germany), and invasive methods included puncture of pleural effusions, transthoracic pleural puncture, drainage, pleural biopsy and video-assisted thoracoscopic pleural biopsy, pleural resection, and ultrasound-guided needle biopsy of the pleura. The following procedures were performed in group I: pleurectomy in 15 patients (16.1%), pleural pneumonectomy in 42 patients (45.2%), pleural decortication in 12 patients (12.9%), extended pleuropneumonectomy with diaphragm and pericardium resections and plastic surgery in 14 patients (15.0%), pleurectomy with costal resections in 10 patients (10.1%). Procedures performed in group II included video-assisted thoracoscopic pleurectomy in 15 patients (19.7%), pleural biopsy in 10 patients (13.2%), pleurectomy in 15 patients (19.7%), pleural drainage and fenestration in 5 patients (6.5%), lung and pleura resection in 12 patients (15.8%), chest wall and pleura resection in 10 patients (13.2%), diaphragm and pleura resections in 9 patients (11.8%).
RESULTS
Early stage primary pleural tumors were found in 24 patients (25.8%). Metastatic pleural disease was found in 32 patients with early primary tumors (80.0%). In all 36 patients (100.0%) with chest wall tumors, disease of advanced stage was determined. Main surgical complications of the group I were observed in 26 patients (27.9%). Six patients (6.5%) died after surgery. In group II, 23 patients (30.2%) had postoperative complications; 3 patients (3.9%) died.
CONCLUSIONS
In noninvasive methods, the highest sensitivity was achieved for chest computed tomography and magnetic resonance imaging (97%); the specificity of chest magnetic resonance imaging was 100%, and the specificity chest computed tomography and magnetic resonance imaging--98%. The accuracy of chest x-ray plus computed tomography was 98%. In invasive methods, accuracies of pleural biopsy, video-assisted thoracoscopic pleural biopsy, and pleurectomy were 100%, 90%, and 100%, respectively. In case of primary pleural tumors, the main surgery was extended pleuropulmonectomy (45.2%) with or without mediastinal resection. Mortality rate was 6.5%. In case of metastatic pleural disease, the main surgery was video-assisted thoracoscopic pleurectomy (19.7%). Mortality was rate 5%. In cases of pleural invasion by other thoracic malignancies, the main surgeries were chest wall and pleural resection (13.2%) and lung and pleural resection (15.8%). Mortality rate was 2.8%. After 169 operations due to malignant pleural diseases, the rate of postoperative complications ranged from 1.3% to 7.8%.
Topics: Aged; Aged, 80 and over; Biopsy, Needle; Data Interpretation, Statistical; Female; Humans; Magnetic Resonance Imaging; Male; Mesothelioma; Neoplasm Staging; Pleura; Pleural Neoplasms; Pneumonectomy; Postoperative Complications; ROC Curve; Radiography, Thoracic; Sensitivity and Specificity; Thoracic Surgery, Video-Assisted; Tomography, X-Ray Computed
PubMed: 19142050
DOI: No ID Found -
Archives of Pathology & Laboratory... Nov 2005We address the current classifications and new changes regarding uncommon primary pleural tumors. Primary pleural tumors are divided according to their behavior and are... (Review)
Review
OBJECTIVE
We address the current classifications and new changes regarding uncommon primary pleural tumors. Primary pleural tumors are divided according to their behavior and are discussed separately as benign tumors, tumors of low malignant potential, and malignant neoplasms.
DATA SOURCES
Current literature concerning primary pleural neoplasms was collected and reviewed.
STUDY SELECTION
Studies emphasizing clinical, radiological, or pathologic findings of primary pleural neoplasms were obtained.
DATA EXTRACTION
Data deemed helpful to the general surgical pathologist when confronted with an uncommon primary pleural tumor was included in this review.
DATA SYNTHESIS
Tumors are discussed in 3 broad categories: (1) benign, (2) low malignant potential, and (3) malignant. A practical approach to the diagnosis of these neoplasms in surgical pathology specimens is offered. The differential diagnosis, including metastatic pleural neoplasms, is also briefly addressed.
CONCLUSIONS
Uncommon primary pleural neoplasms may mimic each other, as well as mimic metastatic cancers to the pleura and diffuse malignant mesothelioma. Correct diagnosis is important because of different prognosis and treatment implications for the various neoplasms.
Topics: Biopsy; Diagnosis, Differential; Humans; Medical Oncology; Mesothelioma; Neoplasm Metastasis; Pleura; Pleural Neoplasms
PubMed: 16253024
DOI: 10.5858/2005-129-1428-RAUOUP